Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort

Parkinson Disease Clinical Trial

— EVALMOB  

Official title:

Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04375280
• Other study ID #: RBHP 2019 COSTES
• Secondary ID: 2019-A01017-50
• Status: Recruiting
• Phase: N/A
• Start date: August 27, 2020
• Est. completion date: September 2031

Study information

• Verified date: August 2020
• Source: University Hospital, Clermont-Ferrand
• Contact: Lise Laclautre
• Phone: 334.73.754.963
• Email: promo_interne_drci[@]chu-clermontferrand.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge both for the treatment of causal pathologies, as well as for evaluating the impact of therapeutic interventions, the benefit of which will be an improvement in physical capacities and ultimately mobility. In view of the hypothesis of an increase in the prevalence of mobility disorders in this population, this approach is part of a logic of screening and improving the effectiveness of the care of these patients with a multidisciplinary evaluation of individual risks. The EVALMOB protocol was designed in order to try to determine a standard profile of "dysmobility" in patients with chronic illness

Description:

We propose to constitute a prospective cohort of subjects carrying chronic disease. The objective is to explore all the different components of mobility (balance, muscle force, body composition, walking ability, metabolism, etc.), to assess their impact on the functional capacity of individuals and to identify their potential interactions. Processing this data could ultimately allow the development of a model to determine a composite standard profile of "dysmobility" in patients with chronic disease.

In the present protocol, parameters will be measured on five occasions (at inclusion, at 6 months from the inclusion day, at 1,2 and 5 year(s) from the inclusion day). All tests will be performed on the same day. New assessments will be done on the same principle as the initial evaluation.

Statistical analyses will be carried out using Stata software (version 13, StataCorp, College Station, USA). Data will be described by frequencies and percentages for categorical variables and by means and standard deviation (or median and interquartile range if data are not normally distributed) for continuous variables. The normality of continuous data will be assessed graphically and using the Shapiro-Wilk test. The main analysis will consist in determining patient profiles regarding their mobility. Clustering-type approaches (supervised or not) will be proposed: k-means, vector machine support, machine learning, factor analysis. For example, factor analyses on mixed data will allow the main components of mobility to be characterized. They can be followed by an ascending hierarchical classification in order to determine homogeneous groups of patients.

These groups will be described and compared on the main criteria evaluated using standard statistical tests: chi2 test (or Fisher's exact test if applicable) for the categorical criteria and using an analysis of variance (or Kruskal-Wallis if data are not normally distributed) for continuous criteria. The main analysis will be broken down more specifically for each of the pathologies considered. In addition, the sensitivity to change will be assessed in each pathology and for each assessment criterion. The search for factors related to the evolution of the different criteria will be carried out using usual tests and mixed multivariate models (logistics for categorical / linear criteria for continuous criteria) considering the subject as a random effect, and adjusting on the time criteria (inclusion / follow-up) and the criteria highlighted in the univariate analyses and in light of the elements reported in the literature. A sensitivity analysis will be proposed in order to study the statistical nature of the missing data and to propose, if necessary, the most suitable method of imputing the data: multiple imputation, maximum bias or LOCF in the case of longitudinal data.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 5000
• Est. completion date: September 2031
• Est. primary completion date: September 2030
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Man or woman aged 18 to 90.

• Patients with chronic pathology contributing to impaired mobility.

• Volunteers who have given their written consent.

• Affiliated to French health care system (for France)

Exclusion Criteria:

• Patients suffering from progressive psychiatric pathologies (active psychosis, hallucinations, etc.) or the presence of another serious unstabilized pathology (decompensated heart failure, progressive terminal cancer, etc.).

• People with poorly controlled or unstable cardiovascular disease.

• Major osteoarticular or neurological problems completely preventing the proper performance of the various tests.

• Non-autonomous patient

• Persons under guardianship, curatorship, deprived of liberty or safeguarding justice.

• People excluded from another study.

• Pregnant or lactating women.

Related Conditions & MeSH terms

• Atherosclerosis
• Atherosclerosis of the Distal Arteries, Without Gangrene
• Chronic Disease
• Chronic Obstructive Pulmonary Disease, Unspecified
• Gangrene
• Joint Osteoarthritis
• Lung Diseases, Obstructive
• Obesity
• Obesity, Unspecified
• Parkinson Disease
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
Firstly, volunteers will be invited to complete online questionnaires on a secure platform. The mobility assessment will be carried out initially (t1) and up to a maximum of 4 times (t1 to t4) as part of a day hospitalization. Questionnaires will be diverse (SF36, KOOS, HOOS, BROCKER, MNA, TAMPA, etc.) in order to assess several aspects that compose mobility. Physical evaluations will include various validated tests (isokinetic strength measure, TUG, 6MWT, Berg Balance Scale, etc.)

Locations

Country	Name	City	State
France	Chu Clermont Ferrand	Clermont-Ferrand

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Clermont-Ferrand	I-SITE Cap 20-25 project

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	dismobility score calculated from the results reported in secondary outcomes	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Day 0
Primary	dismobility score calculated from the results reported in secondary outcomes	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Month 6
Primary	dismobility score calculated from the results reported in secondary outcomes	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Year 1
Primary	dismobility score calculated from the results reported in secondary outcomes	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Year 2
Primary	dismobility score calculated from the results reported in secondary outcomes	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Year 5
Secondary	The main objective being to determine patient profiles with regard to "dysmobility", all the criteria detailed as secondary outcomes will be considered for the definition of the profiles	Demographics information will be obtained using a single questionnaire including questions on age, gender, qualification, personal work status, ethnicity, life and occupational events.	Day 0
Secondary	Weight (Kg).	Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.	Day 0
Secondary	Weight (Kg).	Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.	Month 6
Secondary	Weight (Kg).	Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.	Year 1
Secondary	Weight (Kg).	Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.	Year 2
Secondary	Weight (Kg).	Weight will be measured with the medical body weight scale SECA® and according to the ISAK recommendations.	Year 5
Secondary	Height (cm).	Height will be measured with a wall mounted tape measure and according to the ISAK recommendations	Day 0
Secondary	Height (cm).	Height will be measured with a wall mounted tape measure and according to the ISAK recommendations	Month 6
Secondary	Height (cm).	Height will be measured with a wall mounted tape measure and according to the ISAK recommendations	Year 1
Secondary	Height (cm).	Height will be measured with a wall mounted tape measure and according to the ISAK recommendations	Year 2
Secondary	Height (cm).	Height will be measured with a wall mounted tape measure and according to the ISAK recommendations	Year 5
Secondary	Body fat percentage (%).	Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).	Day 0
Secondary	Body fat percentage (%).	Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).	Month 6
Secondary	Body fat percentage (%).	Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).	Year 1
Secondary	Body fat percentage (%).	Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).	Year 2
Secondary	Body fat percentage (%).	Body fat percentage will be measured with the Harpenden skinfold caliper by measuring skinfold thickness in four different sites (triceps; biceps, suprailiac, subscapular).	Year 5
Secondary	Waist circumference (cm).	Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Day 0
Secondary	Waist circumference (cm).	Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Month 5
Secondary	Waist circumference (cm).	Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 1
Secondary	Waist circumference (cm).	Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 2
Secondary	Waist circumference (cm).	Waist circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 5
Secondary	Hip circumference (cm).	Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Day 0
Secondary	Hip circumference (cm).	Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Month 6
Secondary	Hip circumference (cm).	Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 1
Secondary	Hip circumference (cm).	Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 2
Secondary	Hip circumference (cm).	Hip circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 5
Secondary	Brachial circumference (cm).	Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Day 0
Secondary	Brachial circumference (cm).	Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Month 6
Secondary	Brachial circumference (cm).	Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 1
Secondary	Brachial circumference (cm).	Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 2
Secondary	Brachial circumference (cm).	Brachial circumference will be measured with a medical body tape measure and according to the ISAK recommendations.	Year 5
Secondary	Calf circumference (cm).	Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Day 0
Secondary	Calf circumference (cm).	Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Month 6
Secondary	Calf circumference (cm).	Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 1
Secondary	Calf circumference (cm).	Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 2
Secondary	Calf circumference (cm).	Calf circumference will be measured with a medical body tape measure and according to the ISAK recommendations	Year 5
Secondary	Body Mass Index (Kg/m²).	BMI will be calculated (weight in kilograms divided by height in meters squared).	Day 0
Secondary	Body Mass Index (Kg/m²).	BMI will be calculated (weight in kilograms divided by height in meters squared).	Month 6
Secondary	Body Mass Index (Kg/m²).	BMI will be calculated (weight in kilograms divided by height in meters squared).	Year 1
Secondary	Body Mass Index (Kg/m²).	BMI will be calculated (weight in kilograms divided by height in meters squared).	Year 2
Secondary	Body Mass Index (Kg/m²).	BMI will be calculated (weight in kilograms divided by height in meters squared).	Year 5
Secondary	Body composition	Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.	Day 0
Secondary	Body composition	Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.	Month 6
Secondary	Body composition	Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.	Year 1
Secondary	Body composition	Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.	Year 2
Secondary	Body composition	Body composition (muscle and fat) will be measured using he Bodystat® Impedance-meter.	Year 5
Secondary	T-score (DS).	- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	DAy 0
Secondary	T-score (DS).	- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	T-score (DS).	- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	T-score (DS).	- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	T-score (DS).	- Description: T-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Z-score (DS).	Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Day 0
Secondary	Z-score (DS).	Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Month 6
Secondary	Z-score (DS).	Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 1
Secondary	Z-score (DS).	Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 2
Secondary	Z-score (DS).	Z-score will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 5
Secondary	Fat mass	Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Fat mass	Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Fat mass	Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Fat mass	Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Fat mass	Fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Fat-free mass (%).	: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Fat-free mass (%).	: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Fat-free mass (%).	: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Fat-free mass (%).	: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Fat-free mass (%).	: Fat free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Fat mas index (Kg/m²).	Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Fat mas index (Kg/m²).	Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Fat mas index (Kg/m²).	Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Fat mas index (Kg/m²).	Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Fat mas index (Kg/m²).	Fat mas index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Ratio of android to gynoid fat mass.	Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Day 0
Secondary	Ratio of android to gynoid fat mass.	Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Month 6
Secondary	Ratio of android to gynoid fat mass.	Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 1
Secondary	Ratio of android to gynoid fat mass.	Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 2
Secondary	Ratio of android to gynoid fat mass.	Ratio of android to gynoid fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer	Year 5
Secondary	Visceral adipose tissue (Kg).	Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Visceral adipose tissue (Kg).	Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Visceral adipose tissue (Kg).	Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Visceral adipose tissue (Kg).	Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Visceral adipose tissue (Kg).	Visceral fat mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Fat-free mass index (kg/m²).	: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Fat-free mass index (kg/m²).	: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Fat-free mass index (kg/m²).	: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Fat-free mass index (kg/m²).	: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Fat-free mass index (kg/m²).	: Fat-free mass index will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Appendicular fat-free mass index (Kg/m²).	Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Appendicular fat-free mass index (Kg/m²).	Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Appendicular fat-free mass index (Kg/m²).	Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Appendicular fat-free mass index (Kg/m²).	Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Appendicular fat-free mass index (Kg/m²).	Appendicular fat-free mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Bone mass (Kg)	- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Day 0
Secondary	Bone mass (Kg)	- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Month 6
Secondary	Bone mass (Kg)	- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 1
Secondary	Bone mass (Kg)	- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 2
Secondary	Bone mass (Kg)	- Description: Bone mass will be measured with the Hologic QDR 4500A dual-energy X-ray absorptiometer.	Year 5
Secondary	Daily caloric intake (Kcal/24h).	Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Day 0
Secondary	Daily caloric intake (Kcal/24h).	Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Month 6
Secondary	Daily caloric intake (Kcal/24h).	Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 1
Secondary	Daily caloric intake (Kcal/24h).	Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 2
Secondary	Daily caloric intake (Kcal/24h).	Daily caloric intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 5
Secondary	Daily protein intake (in g and as a percentage of total caloric intake).	Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Day 0
Secondary	Daily protein intake (in g and as a percentage of total caloric intake).	Daily protein intake (in g and as a percentage of total caloric intake).	Month 6
Secondary	Daily protein intake (in g and as a percentage of total caloric intake).	Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 1
Secondary	Daily protein intake (in g and as a percentage of total caloric intake).	Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 2
Secondary	Daily protein intake (in g and as a percentage of total caloric intake).	Daily protein intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 5
Secondary	Daily carbohydrate intake (in g and as a percentage of total caloric intake).	Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Day 0
Secondary	Daily carbohydrate intake (in g and as a percentage of total caloric intake).	Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Month 6
Secondary	Daily carbohydrate intake (in g and as a percentage of total caloric intake).	Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 1
Secondary	Daily carbohydrate intake (in g and as a percentage of total caloric intake).	Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 2
Secondary	Daily carbohydrate intake (in g and as a percentage of total caloric intake).	Daily carbohydrate intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 5
Secondary	Daily fat intake (in g and as a percentage of total caloric intake).	Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Day 0
Secondary	Daily fat intake (in g and as a percentage of total caloric intake).	Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Month 6
Secondary	Daily fat intake (in g and as a percentage of total caloric intake).	Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 1
Secondary	Daily fat intake (in g and as a percentage of total caloric intake).	Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 2
Secondary	Daily fat intake (in g and as a percentage of total caloric intake).	Daily fat intake will be estimated with a 24-hour (all foods and beverages consumed by the respondent in the past 24 hours).	Year 5
Secondary	Nutritional status assessment	Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.	Day 0
Secondary	Nutritional status assessment	Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.	Month 6
Secondary	Nutritional status assessment	Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.	Year 1
Secondary	Nutritional status assessment	Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.	Year 2
Secondary	Nutritional status assessment	Nutritional status assessment will be assessed with the Mini Nutritional Assessment Questionnaire.	Year 5
Secondary	Risk of undernutrition.	Risk of undernutrition will be assessed with the Brocker Questionnaire	Day 0
Secondary	Risk of undernutrition.	Risk of undernutrition will be assessed with the Brocker Questionnaire	Month 6
Secondary	Risk of undernutrition.	Risk of undernutrition will be assessed with the Brocker Questionnaire	Year 1
Secondary	Risk of undernutrition.	Risk of undernutrition will be assessed with the Brocker Questionnaire	Year 2
Secondary	Risk of undernutrition.	Risk of undernutrition will be assessed with the Brocker Questionnaire	Year 5
Secondary	Basic biology.	: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)	Day 0
Secondary	Basic biology.	: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)	Month 6
Secondary	Basic biology.	: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)	Year 1
Secondary	Basic biology.	: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)	Year 2
Secondary	Basic biology.	: Basic biology will be measured using endocrine assays (fasting blood glucose, HbA1c, HDL-c and LDL-c, TG, CPK)	Year 5
Secondary	Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).	: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).	: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).	: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).	: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isometric strength of the quadriceps muscles at 45° (Nm).	: Maximum voluntary isometric strength of the quadriceps muscles will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the quadriceps muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 60°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s (Nm).	- Description: Maximum voluntary isokinetic strength of the hamstring muscles at 240°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Day 0
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Month 6
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 1
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 2
Secondary	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) (Nm).	Maximum voluntary isokinetic strength of the hamstring muscles at 30°/s will be measured with the HUMA® /NORM™ device.	Year 5
Secondary	Endurance coefficient of the quadriceps muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.	Day 0
Secondary	Endurance coefficient of the quadriceps muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.	Month 6
Secondary	Endurance coefficient of the quadriceps muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.	Year 1
Secondary	Endurance coefficient of the quadriceps muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.	Year 2
Secondary	Endurance coefficient of the quadriceps muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device.	Year 5
Secondary	Endurance coefficient of the hamstring muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..	Day 0
Secondary	Endurance coefficient of the hamstring muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..	Month 6
Secondary	Endurance coefficient of the hamstring muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..	Year 1
Secondary	Endurance coefficient of the hamstring muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..	Year 2
Secondary	Endurance coefficient of the hamstring muscles at 180°/s.	Endurance coefficient will be estimated as a S Peak torque ratio of the last 3 contractions on the first 3 at 180°/s with the HUMA® /NORM™ device..	Year 5
Secondary	Functional ratio	Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.	Day 0
Secondary	Functional ratio	Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.	Month 6
Secondary	Functional ratio	Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.	Year 1
Secondary	Functional ratio	Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.	Year 2
Secondary	Functional ratio	Functional ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 60°/s with the maximum voluntary isokinetic strength of the quadriceps muscles at 60°/s.	Year 5
Secondary	Mixed ratio	- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.	Day 0
Secondary	Mixed ratio	- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.	Month 6
Secondary	Mixed ratio	- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.	Year 1
Secondary	Mixed ratio	- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.	Year 2
Secondary	Mixed ratio	- Mixed ratio will be estimated by dividing the maximum voluntary isokinetic strength of the hamstring muscles at 30°/s (eccentric contraction) with the maximum voluntary isokinetic strength of the quadriceps muscles at 240°/s Title: Maximum voluntary strength of the quadriceps muscles at 60°/s.	Year 5
Secondary	Maximum voluntary hand grip strength (Kg).	Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.	Day 0
Secondary	Maximum voluntary hand grip strength (Kg).	Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.	Month 6
Secondary	Maximum voluntary hand grip strength (Kg).	Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.	Year 1
Secondary	Maximum voluntary hand grip strength (Kg).	Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.	Year 2
Secondary	Maximum voluntary hand grip strength (Kg).	Maximum voluntary hand grip strength will be measured with the Jamar® hydraulic dynamometer and with the Baseline® pneumatic dynamometer.	Year 5
Secondary	Maximum voluntary pinch strength (Kg).	Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.	Day 0
Secondary	Maximum voluntary pinch strength (Kg).	Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.	Month 6
Secondary	Maximum voluntary pinch strength (Kg).	Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.	Year 1
Secondary	Maximum voluntary pinch strength (Kg).	Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.	Year 2
Secondary	Maximum voluntary pinch strength (Kg).	Maximum voluntary pinch strength will be measured with the Baseline® pinch gauche test mechanical dynamometer.	Year 5
Secondary	Hip passive joint range	Hip joint range will be measured with a medical goniometer.	Day 0
Secondary	Hip passive joint range	Hip joint range will be measured with a medical goniometer.	Month 6
Secondary	Hip passive joint range	Hip joint range will be measured with a medical goniometer.	Year 1
Secondary	Hip passive joint range	Hip joint range will be measured with a medical goniometer.	Year 2
Secondary	Hip passive joint range	Hip joint range will be measured with a medical goniometer.	Year 5
Secondary	Knee passive joint range.	Knee joint range will be measured with a medical goniometer.	Day 0
Secondary	Knee passive joint range.	Knee joint range will be measured with a medical goniometer.	Month 6
Secondary	Knee passive joint range.	Knee joint range will be measured with a medical goniometer.	Year 1
Secondary	Knee passive joint range.	Knee joint range will be measured with a medical goniometer.	Year 2
Secondary	Knee passive joint range.	Knee joint range will be measured with a medical goniometer.	Year 5
Secondary	Ankle passive joint range	Ankle joint range will be measured with a medical goniometer.	Day 0
Secondary	Ankle passive joint range	Ankle joint range will be measured with a medical goniometer.	Month 6
Secondary	Ankle passive joint range	Ankle joint range will be measured with a medical goniometer.	Year 1
Secondary	Ankle passive joint range	Ankle joint range will be measured with a medical goniometer.	Year 2
Secondary	Ankle passive joint range	Ankle joint range will be measured with a medical goniometer.	Year 5
Secondary	Lower and upper limb muscle power assessment (MRC)	Lower and upper limb muscle power assessment will be performed by an experienced physician.	Day 0
Secondary	Lower and upper limb muscle power assessment (MRC)	Lower and upper limb muscle power assessment will be performed by an experienced physician.	Month 6
Secondary	Lower and upper limb muscle power assessment (MRC)	Lower and upper limb muscle power assessment will be performed by an experienced physician.	Year 1
Secondary	Lower and upper limb muscle power assessment (MRC)	Lower and upper limb muscle power assessment will be performed by an experienced physician.	Year 2
Secondary	Lower and upper limb muscle power assessment (MRC)	Lower and upper limb muscle power assessment will be performed by an experienced physician.	Year 5
Secondary	Statokinesigram surface area (mm²)	Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	Statokinesigram surface area (mm²)	Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	Statokinesigram surface area (mm²)	Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	Statokinesigram surface area (mm²)	Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	Statokinesigram surface area (mm²)	Statokinesigram surface area will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	Stabilogram length (mm).	Stabilogram length will be measured with the STATIPRO® static posturography platform	Day 0
Secondary	Stabilogram length (mm).	Stabilogram length will be measured with the STATIPRO® static posturography platform	Month 6
Secondary	Stabilogram length (mm).	Stabilogram length will be measured with the STATIPRO® static posturography platform	Year 1
Secondary	Stabilogram length (mm).	Stabilogram length will be measured with the STATIPRO® static posturography platform	Year 2
Secondary	Stabilogram length (mm).	Stabilogram length will be measured with the STATIPRO® static posturography platform	Year 5
Secondary	Maximal deflection (forward, backward left and right).	Maximal deflection will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	Maximal deflection (forward, backward left and right).	Maximal deflection will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	Maximal deflection (forward, backward left and right).	Maximal deflection will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	Maximal deflection (forward, backward left and right).	Maximal deflection will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	Maximal deflection (forward, backward left and right).	Maximal deflection will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	Velocity variations (mm/s).	: Velocity variations will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	Velocity variations (mm/s).	: Velocity variations will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	Velocity variations (mm/s).	: Velocity variations will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	Velocity variations (mm/s).	: Velocity variations will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	Velocity variations (mm/s).	: Velocity variations will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	: Romberg ratio according to sway area	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	: Romberg ratio according to sway area	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	: Romberg ratio according to sway area	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	: Romberg ratio according to sway area	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	: Romberg ratio according to sway area	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	Romberg ratio according to center of pressure path length	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	Romberg ratio according to center of pressure path length	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	Romberg ratio according to center of pressure path length	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	Romberg ratio according to center of pressure path length	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	Romberg ratio according to center of pressure path length	Romberg ratio will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	: Plantar pressure ratio sway area.	Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	: Plantar pressure ratio sway area.	Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	: Plantar pressure ratio sway area.	Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	: Plantar pressure ratio sway area.	Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	: Plantar pressure ratio sway area.	Plantar pressure ratio sway area will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	Plantar pressure ratio length.	Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.	Day 0
Secondary	Plantar pressure ratio length.	Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.	Month 6
Secondary	Plantar pressure ratio length.	Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.	Year 1
Secondary	Plantar pressure ratio length.	Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.	Year 2
Secondary	Plantar pressure ratio length.	Plantar pressure ratio length will be measured with the STATIPRO® static posturography platform.	Year 5
Secondary	Walking velocity (cm/s).	Walking velocity will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Walking velocity (cm/s).	Walking velocity will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Walking velocity (cm/s).	Walking velocity will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Walking velocity (cm/s).	Walking velocity will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Walking velocity (cm/s).	Walking velocity will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Cadence (steps/min).	: Cadence will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Cadence (steps/min).	: Cadence will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Cadence (steps/min).	: Cadence will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Cadence (steps/min).	: Cadence will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Cadence (steps/min).	: Cadence will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Step length (left and right foot) (cm)	Step length will be measured with the GAITRite® Electronic Walkway.	DAy 0
Secondary	Step length (left and right foot) (cm)	Step length will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Step length (left and right foot) (cm)	Step length will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Step length (left and right foot) (cm)	Step length will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Step length (left and right foot) (cm)	Step length will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Stride length (cm).	Stride length will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Stride length (cm).	Stride length will be measured with the GAITRite® Electronic Walkway.	month 6
Secondary	Stride length (cm).	Stride length will be measured with the GAITRite® Electronic Walkway.	year 1
Secondary	Stride length (cm).	Stride length will be measured with the GAITRite® Electronic Walkway.	year 2
Secondary	Stride length (cm).	Stride length will be measured with the GAITRite® Electronic Walkway.	year 5
Secondary	Single support time left and right foot (s).	Single support time will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Single support time left and right foot (s).	Single support time will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Single support time left and right foot (s).	Single support time will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Single support time left and right foot (s).	Single support time will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Single support time left and right foot (s).	Single support time will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Double support time (s).	: Double support time will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Double support time (s).	: Double support time will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Double support time (s).	: Double support time will be measured with the GAITRite® Electronic Walkway.	YEar 1
Secondary	Double support time (s).	: Double support time will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Double support time (s).	: Double support time will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Swing time (s).	: Swing time will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Swing time (s).	: Swing time will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Swing time (s).	: Swing time will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Swing time (s).	: Swing time will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Swing time (s).	: Swing time will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Swing phase (as a % of walking cycle).	: Swing phase will be measured with the GAITRite® Electronic Walkway.	DAy 0
Secondary	Swing phase (as a % of walking cycle).	: Swing phase will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Swing phase (as a % of walking cycle).	: Swing phase will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Swing phase (as a % of walking cycle).	: Swing phase will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Swing phase (as a % of walking cycle).	: Swing phase will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Stance phase (as a % of walking cycle).	Stance phase will be measured with the GAITRite® Electronic Walkway.	Day 0
Secondary	Stance phase (as a % of walking cycle).	Stance phase will be measured with the GAITRite® Electronic Walkway.	Month 6
Secondary	Stance phase (as a % of walking cycle).	Stance phase will be measured with the GAITRite® Electronic Walkway.	Year 1
Secondary	Stance phase (as a % of walking cycle).	Stance phase will be measured with the GAITRite® Electronic Walkway.	Year 2
Secondary	Stance phase (as a % of walking cycle).	Stance phase will be measured with the GAITRite® Electronic Walkway.	Year 5
Secondary	Vo2max (maximal oxygen consumption) (mL/Kg/min).	: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Day 0
Secondary	Vo2max (maximal oxygen consumption) (mL/Kg/min).	: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Vo2max (maximal oxygen consumption) (mL/Kg/min).	: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Vo2max (maximal oxygen consumption) (mL/Kg/min).	: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Vo2max (maximal oxygen consumption) (mL/Kg/min).	: Vo2max will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Maximum heart rate (bpm).	Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Day 0
Secondary	Maximum heart rate (bpm).	Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Maximum heart rate (bpm).	Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Maximum heart rate (bpm).	Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Maximum heart rate (bpm).	Maximum heart rate will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Maximum power (Watts).	Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Day 0
Secondary	Maximum power (Watts).	Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Maximum power (Watts).	Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Maximum power (Watts).	Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Maximum power (Watts).	Maximum power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Threshold power (Watts).	Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Day 0
Secondary	Threshold power (Watts).	Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Threshold power (Watts).	Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Threshold power (Watts).	Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Threshold power (Watts).	Threshold power will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Threshold heart rate (bpm).	Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	DAy 0
Secondary	Threshold heart rate (bpm).	Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Threshold heart rate (bpm).	Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Threshold heart rate (bpm).	Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Threshold heart rate (bpm).	Threshold heart will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Forced vital Capacity (L).	: Forced vital Capacity will be measured with a spirometry test.	Day 0
Secondary	Forced vital Capacity (L).	: Forced vital Capacity will be measured with a spirometry test.	Month 6
Secondary	Forced vital Capacity (L).	: Forced vital Capacity will be measured with a spirometry test.	Year 1
Secondary	Forced vital Capacity (L).	: Forced vital Capacity will be measured with a spirometry test.	Year 2
Secondary	Forced vital Capacity (L).	: Forced vital Capacity will be measured with a spirometry test.	Year 5
Secondary	Forced Expiratory volume (L)	Forced Expiratory volume will be measured with a spirometry test.	Day 0
Secondary	Forced Expiratory volume (L)	Forced Expiratory volume will be measured with a spirometry test.	Month 6
Secondary	Forced Expiratory volume (L)	Forced Expiratory volume will be measured with a spirometry test.	Year 1
Secondary	Forced Expiratory volume (L)	Forced Expiratory volume will be measured with a spirometry test.	Year 2
Secondary	Forced Expiratory volume (L)	Forced Expiratory volume will be measured with a spirometry test.	Year 5
Secondary	Tiffeneau ratio (%).	Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.	Day 0
Secondary	Tiffeneau ratio (%).	Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.	Month 6
Secondary	Tiffeneau ratio (%).	Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.	Year 1
Secondary	Tiffeneau ratio (%).	Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.	Year 2
Secondary	Tiffeneau ratio (%).	Tiffeneau ratio will be calculated by dividing the Forced Expiratory volume to the Forced vital Capacity.	Year 5
Secondary	Ventilatory reserve (%).	Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Day 0
Secondary	Ventilatory reserve (%).	Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Month 6
Secondary	Ventilatory reserve (%).	Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 1
Secondary	Ventilatory reserve (%).	Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 2
Secondary	Ventilatory reserve (%).	Ventilatory reserve will be obtained by performing a cardiopulmonary exercise testing at maximal effort during incremental exercise on a cycle ergometer.	Year 5
Secondary	Physical activity	Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)	Day 0
Secondary	Physical activity	Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)	Month 6
Secondary	Physical activity	Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)	Year 1
Secondary	Physical activity	Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)	Year 2
Secondary	Physical activity	Physical activity will be measured using the Global Physical Activity Questionnaire (GPAQ)	Year 5
Secondary	Functional capacity timed-up and go	Functional capacity will be evaluated using the Timed-Up and Go test.	Day 0
Secondary	Functional capacity timed-up and go	Functional capacity will be evaluated using the Timed-Up and Go test.	Month 6
Secondary	Functional capacity timed-up and go	Functional capacity will be evaluated using the Timed-Up and Go test.	Year 1
Secondary	Functional capacity timed-up and go	Functional capacity will be evaluated using the Timed-Up and Go test.	Year 2
Secondary	Functional capacity timed-up and go	Functional capacity will be evaluated using the Timed-Up and Go test.	Year 5
Secondary	Functional capacity TDM6	Functional capacity will be evaluated using the 6-minute walk test.	Day 0
Secondary	Functional capacity TDM6	Functional capacity will be evaluated using the 6-minute walk test.	Month 6
Secondary	Functional capacity TDM6	Functional capacity will be evaluated using the 6-minute walk test.	Year 1
Secondary	Functional capacity TDM6	Functional capacity will be evaluated using the 6-minute walk test.	Year 2
Secondary	Functional capacity TDM6	Functional capacity will be evaluated using the 6-minute walk test.	Year 5
Secondary	Functional capacity Five Times Sit to Stand test.	Functional capacity will be evaluated using the Five Times Sit to Stand test.	Day 0
Secondary	Functional capacity Five Times Sit to Stand test.	Functional capacity will be evaluated using the Five Times Sit to Stand test.	Month 6
Secondary	Functional capacity Five Times Sit to Stand test.	Functional capacity will be evaluated using the Five Times Sit to Stand test.	Year 1
Secondary	Functional capacity Five Times Sit to Stand test.	Functional capacity will be evaluated using the Five Times Sit to Stand test.	Year 2
Secondary	Functional capacity Five Times Sit to Stand test.	Functional capacity will be evaluated using the Five Times Sit to Stand test.	Year 5
Secondary	Functional capacity SPPB	Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.	Day 0
Secondary	Functional capacity SPPB	Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.	Month 6
Secondary	Functional capacity SPPB	Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.	Year 1
Secondary	Functional capacity SPPB	Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.	Year 2
Secondary	Functional capacity SPPB	Functional capacity will be evaluated using the Five Times Sit to Stand test.Functional capacity will be evaluated using the Short Physical Performance Battery test.	Year 5
Secondary	Functional capacity the mini-BESTest.	Functional capacity will be evaluated using the mini-BESTest.	Day 0
Secondary	Functional capacity the mini-BESTest.	Functional capacity will be evaluated using the mini-BESTest.	Month 6
Secondary	Functional capacity the mini-BESTest.	Functional capacity will be evaluated using the mini-BESTest.	Year 1
Secondary	Functional capacity the mini-BESTest.	Functional capacity will be evaluated using the mini-BESTest.	Year 2
Secondary	Functional capacity the mini-BESTest.	Functional capacity will be evaluated using the mini-BESTest.	Year 5
Secondary	Functional capacity Berg Balance Scale.	Functional capacity will be evaluated using the Berg Balance Scale.	Day 0
Secondary	Functional capacity Berg Balance Scale.	Functional capacity will be evaluated using the Berg Balance Scale.	Month 6
Secondary	Functional capacity Berg Balance Scale.	Functional capacity will be evaluated using the Berg Balance Scale.	Year 1
Secondary	Functional capacity Berg Balance Scale.	Functional capacity will be evaluated using the Berg Balance Scale.	Year 2
Secondary	Functional capacity Berg Balance Scale.	Functional capacity will be evaluated using the Berg Balance Scale.	Year 5
Secondary	Functional capacity 10-meter walk test	Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).	Day 0
Secondary	Functional capacity 10-meter walk test	Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).	Month 6
Secondary	Functional capacity 10-meter walk test	Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).	Year 1
Secondary	Functional capacity 10-meter walk test	Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).	Year 2
Secondary	Functional capacity 10-meter walk test	Functional capacity will be evaluated using the 10-meter walk test (at usual and maximal pace).	Year 5
Secondary	Dyspnea	Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Day 0
Secondary	Dyspnea	Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Month 6
Secondary	Dyspnea	Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 1
Secondary	Dyspnea	Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 2
Secondary	Dyspnea	Dyspnea will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 5
Secondary	Perceived exertion before, during and after effort	Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.	DAy 0
Secondary	Perceived exertion before, during and after effort	Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Month 6
Secondary	Perceived exertion before, during and after effort	Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 1
Secondary	Perceived exertion before, during and after effort	Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 2
Secondary	Perceived exertion before, during and after effort	Perceived exertion will be evaluated by a Numeric Rating scale ranging from 0 to 10.	Year 5
Secondary	Pain	: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.	Day 0
Secondary	Pain	: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.	Month 6
Secondary	Pain	: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.	Year 1
Secondary	Pain	: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.	Year 2
Secondary	Pain	: Pain will be measured by a visual analogue scale (VAS) ranging from 0 to 10 and possibly as appropriate by other questionnaires or specific scales.	Year 5
Secondary	Sarcopenia risk	Sarcopenia risk will be evaluated with the SARC-F Questionnaire.	Day 0
Secondary	Sarcopenia risk	Sarcopenia risk will be evaluated with the SARC-F Questionnaire.	Month 6
Secondary	Sarcopenia risk	Sarcopenia risk will be evaluated with the SARC-F Questionnaire.	Year 1
Secondary	Sarcopenia risk	Sarcopenia risk will be evaluated with the SARC-F Questionnaire.	Year 2
Secondary	Sarcopenia risk	Sarcopenia risk will be evaluated with the SARC-F Questionnaire.	Year 5
Secondary	Social insecurity	Social insecurity will be evaluated with the EPICES Score Questionnaire.	Day 0
Secondary	Social insecurity	Social insecurity will be evaluated with the EPICES Score Questionnaire.	Month 6
Secondary	Social insecurity	Social insecurity will be evaluated with the EPICES Score Questionnaire.	Year 1
Secondary	Social insecurity	Social insecurity will be evaluated with the EPICES Score Questionnaire.	Year 2
Secondary	Social insecurity	Social insecurity will be evaluated with the EPICES Score Questionnaire.	Year 5
Secondary	Kinesiophobia	Kinesiophobia will be evaluated with the TAMPA Scale.	Day 0
Secondary	Kinesiophobia	Kinesiophobia will be evaluated with the TAMPA Scale.	Month 6
Secondary	Kinesiophobia	Kinesiophobia will be evaluated with the TAMPA Scale.	Year 1
Secondary	Kinesiophobia	Kinesiophobia will be evaluated with the TAMPA Scale.	Year 2
Secondary	Kinesiophobia	Kinesiophobia will be evaluated with the TAMPA Scale.	Year 5
Secondary	Quality of life	Quality of life will be evaluated with the 36-Item Short Form Survey.	Day 0
Secondary	Quality of life	Quality of life will be evaluated with the 36-Item Short Form Survey.	Month 6
Secondary	Quality of life	Quality of life will be evaluated with the 36-Item Short Form Survey.	Year 1
Secondary	Quality of life	Quality of life will be evaluated with the 36-Item Short Form Survey.	Year 2
Secondary	Quality of life	Quality of life will be evaluated with the 36-Item Short Form Survey.	Year 5
Secondary	: Balance confidence in performing various activities	Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.	Day 0
Secondary	: Balance confidence in performing various activities	Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.	Month 6
Secondary	: Balance confidence in performing various activities	Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.	Year 1
Secondary	: Balance confidence in performing various activities	Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.	Year 2
Secondary	: Balance confidence in performing various activities	Self-report balance confidence will be evaluated with the Activities-specific Balance Confidence (ABC) Scale.vey.	Year 5
Secondary	Functioning in regards to activities of daily living.	Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.	Day 0
Secondary	Functioning in regards to activities of daily living.	Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.	Month 6
Secondary	Functioning in regards to activities of daily living.	Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.	Year 1
Secondary	Functioning in regards to activities of daily living.	Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.	Year 2
Secondary	Functioning in regards to activities of daily living.	Functioning will be evaluated with the Lawton Instrumental Activities of Daily Living (IADL) Scale.	Year 5
Secondary	Exhaustion	Exhaustion will be evaluated with the FACIT-F Questionnaire.	Day 0
Secondary	Exhaustion	Exhaustion will be evaluated with the FACIT-F Questionnaire.	Month 6
Secondary	Exhaustion	Exhaustion will be evaluated with the FACIT-F Questionnaire.	Year 1
Secondary	Exhaustion	Exhaustion will be evaluated with the FACIT-F Questionnaire.	Year 2
Secondary	Exhaustion	Exhaustion will be evaluated with the FACIT-F Questionnaire.	Year 5
Secondary	Patient's opinion about their knee and associated problems	: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).	Day 0
Secondary	Patient's opinion about their knee and associated problems	: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).	Month 6
Secondary	Patient's opinion about their knee and associated problems	: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).	Year 1
Secondary	Patient's opinion about their knee and associated problems	: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).	Year 2
Secondary	Patient's opinion about their knee and associated problems	: Outcomes will be evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS).	Year 5
Secondary	Patient's opinion about their hip and associated problems	Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).	Day 0
Secondary	Patient's opinion about their hip and associated problems	Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).	Month 6
Secondary	Patient's opinion about their hip and associated problems	Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).	Year 1
Secondary	Patient's opinion about their hip and associated problems	Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).	Year 2
Secondary	Patient's opinion about their hip and associated problems	Outcomes will be evaluated with the Hip Injury and Osteoarthritis Outcome Score (HOOS).	Year 5
Secondary	Predicting discharge destination after total joint arthroplasty.	: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);	Day 0
Secondary	Predicting discharge destination after total joint arthroplasty.	: Discharge destination will be evaluated with the Risk Assessment and Prediction Tool (RAPT);	Month 6
Secondary	Physical function in myositis patients	Physical function will be evaluated with the Stanford Health Assessment Questionnaire.	Day 0
Secondary	Physical function in myositis patients	Physical function will be evaluated with the Stanford Health Assessment Questionnaire.	Month 6
Secondary	Physical function in myositis patients	Physical function will be evaluated with the Stanford Health Assessment Questionnaire.	Year 1
Secondary	Physical function in myositis patients	Physical function will be evaluated with the Stanford Health Assessment Questionnaire.	Year 2
Secondary	Physical function in myositis patients	Physical function will be evaluated with the Stanford Health Assessment Questionnaire.	Year 5
Secondary	Quality of life in Parkinson's Disease	Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).	Day 0
Secondary	Quality of life in Parkinson's Disease	Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).	Month 6
Secondary	Quality of life in Parkinson's Disease	Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).	Year 1
Secondary	Quality of life in Parkinson's Disease	Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).	Year 2
Secondary	Quality of life in Parkinson's Disease	Quality of life will be measured with the Parkinson's Disease Questionnaire-39 (PDQ-39).	Year 5
Secondary	Actimetry.	Actimetry data (energy expenditure, number of steps, sedentary time, total physical activity, etc.) will be obtained with the WGT3X-BT Actigraph inertial sensor unit.	during 5 consecutive days after day 0