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Paralysis clinical trials

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NCT ID: NCT03783572 Recruiting - Stroke Clinical Trials

Upper-limb Active Function and Botulinum Toxin A

ULAFBoT-Stroke
Start date: December 8, 2020
Phase: N/A
Study type: Interventional

This study in an observational, prospective and longitudinal study. The aim of the study is to evaluate the effect of botulinum toxin type A (BTX) injections into the elbow flexors on the reduction of spastic co-contractions (spastic co-contraction index, SCCI) during an active elbow extension in chronic post-stroke patients.TBA injections are performed as part of routine care

NCT ID: NCT03781700 Recruiting - Bell Palsy Clinical Trials

Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy

FACE
Start date: May 3, 2019
Phase: Phase 4
Study type: Interventional

Acute facial nerve palsy occur in 10-20/100 000 children/year in Sweden. About 20 % of these children will have persistent symptoms with excessive tear secretion, drooling and social problems due to asymmetry in the face. Studies on cortisone treatment to adult patients with acute facial nerve palsy have shown beneficial effects, but no studies with strong quality have been performed in children. Investigators will perform a double-blind randomized placebo-controlled multicenter trial on children with acute facial nerve palsy. Participants will be recruited consecutively at 9-12 study centers in Sweden during 2019-2020. Oral cortisone (prednisolone) 1 mg/kg x 1 in 10 days (or placebo) will be started on admission. Clinical data, including recovery will be followed-up until 12 months. The primary outcome is defined as total recovery of the facial nerve palsy, measured with the House-Brackmann scale (grade 1) at 12-months follow-up. The overall purpose is to assess the utility of cortisone treatment given to children with acute facial nerve palsy in this study. If the total recovery rate is significantly improved in the prednisolone group as compared to the placebo group, prednisolone treatment will be introduced in clinical practice for children with acute facial nerve palsy in order to reduce the risk of persistent symptoms.

NCT ID: NCT03778398 Recruiting - Cerebral Palsy Clinical Trials

Music Therapy In Adolescents With Cerebral Palsy

Start date: June 20, 2018
Phase: N/A
Study type: Interventional

Purpose of the study; - To improve the upper extremity motor functions of patients with adolescent cerebral palsy, - Prevent treatment interruptions as age progresses, - Increase the hand functions of children with cerebral palsy and to increase their living standards. Hand functions will be assessed with MACS (Manual Ability Classification System), hand dynamometer, box-block test, 9 hole peg test, pressing velocity measured with Cubase MIDI (musical instrument data interface) program. Patients will receive 2 days of 40 minutes per week, total 3 months of customized piano training. Each session will be started with finger warming exercises, then with the right hand, left handed and with both hands, a simple pentatonic array will be played. In the following lessons, notes will be marked with colors and simple songs will be taught. At the end of 3 months, the tests will be repeated.

NCT ID: NCT03771599 Recruiting - Clinical trials for Cerebral Palsy, Spastic, Diplegic

The Effects of Traditional Massage on Spasticity and Activity of Children(2 to 10 Years) With Cerebral Palsy

Start date: September 1, 2016
Phase: N/A
Study type: Interventional

The study has been conducted to see the effects of traditional massage on spasticity and activity of children with cerebral palsy (CP). It is a randomized controlled trial having two groups, control and intervention. Both groups received routine physical therapy treatment comprising stretching of tight muscles, strengthening of weak muscles, positioning and handling. Intervention group also received traditional massage in addition to routine physical therapy. Caregivers were trained to perform routine physical therapy treatment and traditional massage at home. Data was collected using a structured questionnaire, Modified Ashworth Scale (MAS), Gross Motor Function Classification System (GMFCS), Gross Motor Function Measure (GMFM) and CPChild Caregiver Priorities & Child Health Index of Life with Disabilities at baseline, after 06 weeks and 12 weeks of intervention.

NCT ID: NCT03744884 Recruiting - Clinical trials for Cerebral Palsy, Spastic

Movement Characterization in Spastic/Dystonic Cerebral Palsy Using Haptic Feedback in Virtual Reality

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

This game-like intervention using virtual reality will provide an objective and quantitative characterization of dystonia and spasticity presentations in cerebral palsy, even if combined, through the process of motor learning. This intervention could have a therapeutic benefit in the rehabilitation of children with cerebral palsy.

NCT ID: NCT03634956 Recruiting - Clinical trials for Vocal Cord Paralysis

Effect of IONM on Efficacy and Safety Using Sugammadex in Thyroid Surgery

Start date: August 14, 2018
Phase: N/A
Study type: Interventional

Thyroidectomy is a frequently performed surgeon by the head and neck and endocrine surgeons. In recent years, surgical techniques and technological developments have resulted in a significant reduction in complication rates. Despite these advances, there is still a great deal of anxiety about the sound problems that can be experienced in patients after surgery. In the past years,the investigators have tried to prevent recurrent nerve paralysis by using intraoperative nerve monitoring (IONM). The use of IONM has begun to be preferred by many surgeons in the investigator's country. However, the use of IONM decreases the number of recurrent nerve paralysis are still being discussed and many studies have been done. In this study, it is aimed to prevent the formation of recurrent nerve paralysis in order to safely carry out the IONM by removing the effects of neuromuscular blockade drugs using sugammadex sodium medicine in the thyroidectomy operations.

NCT ID: NCT03581253 Recruiting - Quality of Life Clinical Trials

Validation of a French-language Version of Quality of Life Questionnaires in Patients With Peripheral Facial Palsy

PFQDV
Start date: December 15, 2017
Phase: N/A
Study type: Interventional

Facial palsy is a serious and disabling disease whose drudgery and sensation are probably underestimated. Psychological, social and economic issues have major impacts although vital prognosis is not engaged in this pathology. Facial palsy remains a personal drama for patient. Consequences may take the form of: aesthetic deformation, modification of body image, with socio-professional consequences. Beside unsightly facial aspects, weakness of facial muscles can cause troubles in eating, drinking, talking, communicating personal emotions and communication. Facial palsy impacts patients' quality of life (QOL) and affects mental health. This wide multidimensional concept usually includes self-measures of physical and mental health. QOL is evaluated with general and specific scales. General scales allow to compare QOL of different diseases, when specific scales focus on one disease and consider all aspects related to this disease and therefore are more appropriate and sensitive in dimensions related to patient disease and health. "Facial disability Index" (FDi) and "Facial Clinimetric Evaluation" (FaCE) are the most used validated questionnaires to assess QOL of patients suffering from peripheral facial palsy (PFP). There is no existing validated questionnaire or scale in French version despite many French studies on PFP available. Using these questionnaires in French language requires translation and strict approval of the new language version. The aim of the study is to translate and validate French versions of specific scales of QOL in peripheral facial palsy patients: FDI and FaCE. Secondary objective is to evaluate QOL of patients depending on PFP etiology. Translation process will be done respecting internationally recognized rules. A pilot study will be performed on 5 physicians and 5 patients in order to validate the questionnaires translations. French versions obtained will be used for their validation on 80 patients suffering from PFP. Cronbach's alpha will be estimated to check internal consistency of FDI and FaCE scales. Test re-test reliability will be calculated with inter-class correlation, reiterating questionnaires one week later. Scores of FDI and FaCE scales will be compared to other clinical evaluation scales, estimating correlation coefficient. Social function of FDI and FaCE scales will be compared with general scale SF-36 scores, estimating a correlation coefficient.

NCT ID: NCT03567239 Recruiting - Stroke Clinical Trials

Impact of Custom Assistive and Adaptive Technology in Rehabilitation

Start date: June 25, 2018
Phase: N/A
Study type: Interventional

Madonna's Rehabilitation Engineering Center of Excellence (REC) is continually developing custom devices for persons with disabilities. These devices are created to improve the independence of individuals living with disabilities at Madonna Rehabilitation Hospitals and in the community. The purpose of this study is to investigate the impact custom assistive and adaptive devices have on patient independence, quality of life, and experience at Madonna Rehabilitation Hospitals.

NCT ID: NCT03553342 Recruiting - Clinical trials for Recurrent Paralysis of Vocal Cords

Efficacy of Oral Corticosteroid Therapy in Recurrent Paralyzes After Thyroidectomy

Start date: September 11, 2018
Phase: Phase 3
Study type: Interventional

Thyroidectomy is a common surgical procedure in France. Recurrent paralysis is one of the main complications. Oral corticosteroid therapy are frequently used at a dosage of 1mg/kg for seven days, in case of recurrent paralysis to obtain remobilization as early as possible. The main objective is to evaluate the efficacy of oral corticosteroid therapy in remobilization of vocal cords at seven days in patients with unilateral recurrent paralysis after thyroidectomy.

NCT ID: NCT03469427 Recruiting - Clinical trials for Facial Nerve Paralysis

Multislice Computed Tomography in Cases With Facial Nerve Paralysis Due to Temporal Bone Trauma

Start date: May 1, 2018
Phase:
Study type: Observational

Facial nerve paralysis is a disfiguring complication which occurs in 7-10 % of temporal bone fractures. The onset of paralysis may be immediate, delayed or undetermined, the latter of which often occurs in unconscious patients with accompanying life-threatening complications.About one fourth has complete paralysis.