Pain Clinical Trial
Official title:
Temporal Profile of the Nociceptive Desensitization Induced by 8% Topical Capsaicin and the Functional Independence of Transient Receptor Potential Ankyrin 1 (TPRA1)- and Vanilloid 1 (TRPV1)-Expressing Nociceptive Afferents
The purpose of this study is to investigate the potential desensitising effects of repeated applications of capsaicin, trans-cinnamaldehyde and L-menthol on thermal, mechanical and chemical sensory stimulations.
Capsaicin, the compound responsible for the pungency of chili peppers, can induce
desensitization to nociceptive (1) and pruriceptive (2) stimuli when topically applied. The
purpose of this study is to determine whether repeated topical applications of
trans-cinnamaldehyde and L-menthol result in decreased responses to various nociceptive and
non-nociceptive thermal and mechanical stimuli and to compare potential alterations with
those caused by repeated topical application of capsaicin. Furthermore, this study
investigates the temporal profile of said alterations.
Capsaicin 8% patches, trans-cinnamaldehyde 10%, L-menthol 40% and inert vehicle patches will
each be applied to 4 4x4 cm predefined areas on the skin of the volar forearms for 1 hour 4
times on 4 consecutive days. Before each application and the day after the last application,
cold detection threshold (CDT), warmth detection threshold (WDT), cold pain threshold (CPT)
and heat pain threshold (HPT) will be assessed using a Medoc Pathway (Medoc, Israel)
equipped with a 3x3 cm contact thermode. On the last day, mechanical detection threshold
(MDT) is assessed using a series of von Frey filaments and mechanical pain threshold (MPT)
and mechanical pain sensitivity (MPS) is assessed using a series of standardized pinprick
stimulators (Aalborg University).
Furthermore, full-field laser perfusion imaging (FLPI) will be used to assess the degree of
neurogenic inflammation in each predefined area before and after each substance application
and at the last session.
1. F. Henrich et al. 2015 "Capsaicin-sensitive C- and A-fibre nociceptors control
long-term potentiation-like pain amplification in humans"
2. H.H. Andersen et al. 2017 "Antipruritic effect of pretreatment with 8% topical
capsaicin on histamine- and cowhage-evoked itch in healthy volunteers - a randomized
placebo-blinded proof-of-concept trial"
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