Efficacy of Ketamine in Post Anesthesia Recovery Room

Pain, Postoperative Clinical Trial

Official title:

Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04701008
• Other study ID #: Pro00102967
• Status: Completed
• Start date: September 1, 2020
• Est. completion date: May 28, 2021

Study information

• Verified date: July 2022
• Source: University of Alberta
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Description:

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 143
• Est. completion date: May 28, 2021
• Est. primary completion date: May 28, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

• age = 18

• significant pain despite narcotics used in post-anesthesia care unit

• ketamine ordered by attending anesthesiologist

Exclusion Criteria:

• Patient refusal to receive ketamine

• Patients undergoing cardiac surgery

• Patients who received no narcotics

• Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Related Conditions & MeSH terms

• Acute Pain
• Ketamine Adverse Reaction
• Pain, Acute
• Pain, Intractable
• Pain, Postoperative
• Pain, Refractory

Intervention

Drug:
• Ketamine
IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Locations

Country	Name	City	State
Canada	University of Alberta Hospital	Edmonton	Alberta

Sponsors (1)

Lead Sponsor	Collaborator
University of Alberta

Country where clinical trial is conducted

Canada, 

References & Publications (3)

Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, Kontinen V. Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018 Dec 20;12:CD012033. doi: 10.1002/14651858.CD012033.pub4. — View Citation

Gillies A, Lindholm D, Angliss M, Orr A. The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients. Anaesth Intensive Care. 2007 Apr;35(2):199-203. — View Citation

Weinbroum AA. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain. Anesth Analg. 2003 Mar;96(3):789-795. doi: 10.1213/01.ANE.0000048088.17761.B4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reduction in pain score after ketamine use in PACU	The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.	in the immediate post-operative period in recovery room
Secondary	Incidence of side effects after ketamine use		in the immediate post-operative period in recovery room