Clinical Trials Logo

Clinical Trial Summary

Randomised Clinical Study to evaluate the efficacy of tilapia skin as an occlusive biological dressing on palatal wound healing after free gingival graft harvesting.


Clinical Trial Description

Autogenous grafts are currently considered the gold standard in regenerative and reconstructive procedures. However, these procedures require a second surgical site to provide the tissue graft. In autogenous gingival grafts, the area commonly selected for graft harvesting is the palate, which is linked to great discomfort and morbidity for the patient. In order to overcome these limitations, xenogeneic and alloplastic materials have been tested as tissue substitutes, but their results are still considerably inferior when compared to autogenous grafts. Faced with this superiority, another approach to favor the use of autogenous grafting is to develop materials that provide greater postoperative comfort and patient safety. Since the main complaint arising from the technique is related to pain resulting from the remaining surgical wound on the palate, it is interesting to look for mechanisms to reduce this sensitivity and accelerate the healing process. For this, the use of tilapia skin as a postoperative dressing seems to be a good alternative. Thus, the purpose of this study is to evaluate the use of tilapia skin, with the intention of accelerating the palate healing process, and to serve as a protector barrier during the healing process. Patients treated according to two techniques for palate protection after autogenous gingival graft harvesting will be evaluated: C- use of surgical cement and T- use of tilapia skin. Will be selected 60 patients of both sexes,> 18 years old, requiring the removal of the palate graft for periodontal surgery. At the time of graft removal, palate thickness and graft dimensions will be measured. After 7, 14 and 30 days, the patient's discomfort and the difficulty in chewing and speaking will be recorded through a visual analog scale, the consumption of analgesic, and the dimensions of the surgical wound on the palate. For statistical analysis, two-way ANOVA will be performed and t-test paired on the obtained results. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04168125
Study type Interventional
Source University of Sao Paulo
Contact Gustavo GP Manfredi, MSc
Phone +5518981711825
Email [email protected]
Status Recruiting
Phase Phase 1
Start date September 26, 2019
Completion date March 24, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT04526236 - Influence of Aging on Perioperative Methadone Dosing Phase 4
Recruiting NCT04020133 - the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction. N/A
Completed NCT03023462 - Effectiveness of a Transmuscular Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair N/A
Recruiting NCT03546738 - Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery N/A
Completed NCT03652103 - Efficiency of Erector Spinae Plane Block For Patients Undergoing Percutaneous Nephrolithotomy Phase 4
Recruiting NCT03261193 - ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain Phase 3
Withdrawn NCT03528343 - Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy Phase 1/Phase 2
Completed NCT02525133 - Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty Phase 3
Completed NCT03244540 - Regional Analgesia After Cesarean Section Phase 4
Recruiting NCT04130464 - Intraperitoneal Infusion of Analgesic for Postoperative Pain Management Phase 4
Enrolling by invitation NCT04574791 - Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty N/A
Completed NCT04073069 - Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults Phase 4
Completed NCT04919317 - Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty Phase 2
Recruiting NCT04551196 - Management of Post-Tonsillectomy Pain in Pediatric Patients Phase 3
Completed NCT03245359 - Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks N/A
Completed NCT04130802 - OCS-01 in Treating Inflammation and Pain in Post-cataract Patients Phase 2
Recruiting NCT04094246 - Battlefield Acupuncture Following Shoulder Surgery N/A
Active, not recruiting NCT03302689 - Comparison Levobupivacaine and Ropivacaine for TAP-block After Caesarean Section N/A
Recruiting NCT03834922 - Providing Standardized Consented PROMs (Patient Reported Outcome Measures) for Improving Pain Treatment
Recruiting NCT04561596 - Virtually Augmented Self Hypnosis in Peripheral Vascular Interventions N/A