The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity Clinical Trial

Official title:

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and the Decline in Kidney Function in Participants With Body Mass Index ≥27 kg/m^2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06383390
• Other study ID #: 18584
• Secondary ID: J1I-MC-GZBO2023-
• Status: Recruiting
• Phase: Phase 3
• Start date: April 30, 2024
• Est. completion date: February 2029

Study information

• Verified date: May 2024
• Source: Eli Lilly and Company
• Contact: There may be multiple sites in this clinical trial. 1-877-CTLILL
• Phone: 1-317-615-4559
• Email: ClinicalTrials.gov[@]lilly.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10000
• Est. completion date: February 2029
• Est. primary completion date: February 2029
• Accepts healthy volunteers: No
• Gender: All
• Age group: 45 Years and older

Eligibility

Inclusion Criteria:

• A Body Mass Index of =27.0 kilograms per meter squared (kg/m^2)

• Participants may be with or without type 2 diabetes (T2D) unless their hemoglobin A1c (HbA1c) is 10% or lower

• Participants have established atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD), as evidenced at least one of the following:

• Coronary artery disease

• Cerebrovascular disease

• Peripheral arterial disease

• Chronic kidney disease defined as:

• eGFR <45 millilitres/minute/1.73 meter squared (mL/min/1.73m^2) and UACR >30 milligram/gram (mg/g)

• eGFR <60 mL/min/1.73 m^2 and UACR >100 mg/g, or

• eGFR <75 mL/min/1.73 m^2 and UACR >300 mg/g (eGFR is calculated based on Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin c equation as determined by central lab)

Exclusion Criteria:

Diabetes related:

• Participants have Type 1 Diabetes or history of diabetic ketoacidosis

CV related:

• Participants have any of the following cardiovascular conditions = 90 days prior to randomization:

• Myocardial infarction

• Acute coronary syndrome

• Stroke, or

• Coronary, peripheral, or carotid artery arterial revascularization procedure.

• Have acute decompensated heart failure requiring hospitalization.

• Have New York Heart Association (NYHA) Classification Class IV heart failure at screening

Kidney related:

• Participants have an eGFR <20 mL/min/1.73 m^2 at screening

• Have UACR >5000 mg/g at screening

• Have received any form of dialysis = 90 days from the date of randomization

• Have either undergone a kidney transplant or have a transplant procedure scheduled

Other medical conditions:

• Participants have had or plan to have a surgical treatment for obesity,

• Have a history of chronic or acute pancreatitis

• Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome type 2

• Have a known clinically significant gastric emptying abnormality, such as severe gastroparesis or gastric outlet obstruction

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Obesity
• Overweight
• Overweight and Obesity

Intervention

Drug:
• Retatrutide
Administered SC
• Placebo
Administered SC

Locations

Country	Name	City	State
Argentina	Buenos Aires Macula S.A	Buenos Aires
Argentina	Cardiología Palermo	Buenos Aires
Argentina	CEMEDIC	Buenos Aires
Argentina	Centro Médico Viamonte	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	CIPREC	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	CIPREC	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	CONEXA Investigacion Clinica S.A.	Buenos Aires
Argentina	Fundación Respirar	Buenos Aires
Argentina	Glenny Corp	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	Instituto Médico Especializado (IME)	Buenos Aires
Argentina	Investigaciones Medicas Imoba Srl	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	Mautalen Salud e Investigación	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	Stat Research S.A.	Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	CEMEDIAB	C.a.b.a.	Ciudad Autónoma De Buenos Aires
Argentina	CEDIC	Caba	Buenos Aires
Argentina	Centro Medico Privado CEMAIC	Capital	Córdoba
Argentina	Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada	Ciudad Autonoma de Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	Consultorio de Investigación Clínica EMO SRL	Ciudad Autonoma de Buenos Aires	Ciudad Autónoma De Buenos Aires
Argentina	Centro de Investigaciones Metabólicas (CINME)	Ciudad Autónoma de Buenos Aires	Buenos Aires
Argentina	IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas	Ciudad de Buenos Aires	Buenos Aires
Argentina	Centro Medico Privado San Vicente Diabetes	Cordoba	Córdoba
Argentina	Centro Diabetológico Dr. Waitman	Córdoba
Argentina	Centro Médico Colón	Córdoba
Argentina	CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani	Córdoba
Argentina	Instituto de Investigaciones Clínicas Córdoba	Córdoba
Argentina	Sanatorio Privado Duarte Quirós	Córdoba
Argentina	CIPADI - Centro Integral de Prevencion y Atencion en Diabetes	Godoy Cruz	Mendoza
Argentina	Centro de Investigaciones Clínicas Baigorria	Granadero Baigorria	Santa Fe
Argentina	Centro Médico Lebensohn	Junín	Buenos Aires
Argentina	Hospital Italiano de La Plata	La Plata	Buenos Aires
Argentina	CIMeL Clinical Research	Lanus	Buenos Aires
Argentina	Polo de Salud Vistalba	Luján de Cuyo	Mendoza
Argentina	Centro de Investigaciones Médicas Mar del Plata	Mar del Plata	Buenos Aires
Argentina	Instituto de Investigaciones Clínicas Mar del Plata	Mar del Plata	Buenos Aires
Argentina	Clínica Privada Independencia	Munro	Buenos Aires
Argentina	Instituto De Investigaciones Clinicas Quilmes	Quilmes	Buenos Aires
Argentina	DIM Clínica Privada	Ramos Mejía	Buenos Aires
Argentina	Instituto Médico Río Cuarto	Río Cuarto	Córdoba
Argentina	Fundacion Estudios Clinicos	Rosario	Santa Fe
Argentina	Hospital Provincial del Centenario	Rosario	Santa Fe
Argentina	INECO Neurociencias Oroño	Rosario	Santa Fe
Argentina	Instituto de Especialidades de la Salud Rosario	Rosario	Santa Fe
Argentina	Instituto de Investigaciones Clinicas Rosario	Rosario	Santa Fe
Argentina	Instituto Médico Catamarca IMEC	Rosario	Santa Fe
Argentina	Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica	Rosario	Santa Fe
Argentina	Laboratorio de Hemostasia y Trombosis	Rosario	Santa Fe
Argentina	Centro Medico Privado de Reumatologia	SAN M. DE Tucuman	Tucumán
Argentina	Corporación Médica San Martín	San Martín	Buenos Aires
Argentina	Centro Modelo de Cardiología	San Miguel de Tucuman	Tucumán
Argentina	Investigaciones Clínicas Tucumán	San Miguel de Tucuman	Tucumán
Argentina	Go Centro Medico San Nicolás	San Nicolas	Buenos Aires
Argentina	Centro de Diagnóstico y Rehabilitación (CEDIR)	Santa Fe
Argentina	Centro de Investigaciones Clinicas del Litoral	Santa Fe
Argentina	Clínica de Nefrología, Urología y Enfermedades Cardiovasculares	Santa Fe
Argentina	Centro de Salud e Investigaciones Médicas	Santa Rosa	La Pampa
Argentina	Sanatorio Norte	Santiago del Estero
Argentina	CEREHA	Sarandi	Buenos Aires
Argentina	Centro de Investigaciones Medicas Temperley	Temperley	Buenos Aires
Argentina	Sanatorio San Martin	Venado Tuerto	Santa Fe
Argentina	Instituto de Investigaciones Clinicas Zarate	Zárate	Buenos Aires
Australia	Nightingale Research	Adelaide	South Australia
Australia	Optimus Clinical Research	Botany	New South Wales
Australia	Box Hill Hospital	Box Hill	Victoria
Australia	Royal Brisbane and Women's Hospital	Brisbane	Queensland
Australia	Northern Beaches Clinical Research	Brookvale	New South Wales
Australia	Emeritus Research	Camberwell	Victoria
Australia	Canberra Hospital	Garran	Australian Capital Territory
Australia	Barwon Health	Geelong	Victoria
Australia	Austin Health - Repatriation Hospital	Heidelberg West	Victoria
Australia	Liverpool Hospital	Liverpool	New South Wales
Australia	Logan Hospital	Meadowbrook	Queensland
Australia	The Alfred Hospital	Melbourne	Victoria
Australia	The AIM Centre / Hunter Diabetes Centre	Merewether	New South Wales
Australia	Fiona Stanley Hospital	Murdoch	Western Australia
Australia	Southern Adelaide Diabetes & Endocrine Services	Oaklands Park	South Australia
Australia	Royal North Shore Hospital	St Leonards	New South Wales
Australia	University of Sydney - Charles Perkins Centre	Sydney	New South Wales
Austria	Krankenhaus St. Josef Braunau	Braunau	Oberösterreich
Austria	VIVIT	Feldkirch	Vorarlberg
Austria	Medizinische Universität Graz	Graz	Steiermark
Austria	Medizinische Universitaet Innsbruck	Innsbruck	Tirol
Austria	Konventhospital der Barmherzigen Brüder Linz	Linz	Oberösterreich
Austria	Private Practice - Dr. Evelyn Fliesser-Gorzer	Sankt Stefan ob Stainz	Steiermark
Austria	Imed19-privat	Vienna
Austria	Medizinische Universität Wien	Vienna	Wien
Austria	Zentrum für klinische Studien Dr Hanusch Gmbh	Vienna	Wien
Austria	Klinik Hietzing	Wien
Austria	Klinik Landstraße	Wien
Belgium	Onze Lieve Vrouw Ziekenhuis Aalst	Aalst	Oost-Vlaanderen
Belgium	Imelda General Hospital	Bonheiden	Antwerpen
Belgium	Algemeen Ziekenhuis klina	Brasschaat	Antwerpen
Belgium	Cliniques universitaires Saint-Luc	Brussels	Bruxelles-Capitale, Région De
Belgium	Université Libre de Bruxelles - Hôpital Erasme	Brussels	Bruxelles-Capitale, Région De
Belgium	UZ Brussel	Brussels	Bruxelles-Capitale, Région De
Belgium	Antwerp University Hospital	Edegem	Antwerpen
Belgium	UZ Gent	Gent	Oost-Vlaanderen
Belgium	Jessa Ziekenhuis	Hasselt	Limburg
Belgium	Kormont	Kluisbergen	Oost-Vlaanderen
Belgium	Kormont	Kluisbergen	Oost-Vlaanderen
Belgium	Kormont	Kluisbergen	Oost-Vlaanderen
Belgium	AZ Groeninge Campus Kennedylaan	Kortrijk	West-Vlaanderen
Belgium	UZ Leuven	Leuven	Vlaams-Brabant
Belgium	Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman	Liège
Belgium	ZNA Jan Palfijn	Merksem	Vlaams Gewest
Belgium	Az Damiaan vzw	Oostende	West-Vlaanderen
Brazil	Centro de Pesquisa Clinica do Coracao	Aracaju	Sergipe
Brazil	Hospital Universitário João de Barros Barreto	Belem	Pará
Brazil	Consultoria em Controle de Infecção Hospitalar	Belo Horizonte	Minas Gerais
Brazil	Santa Casa de Misericordia de Belo Horizonte	Belo Horizonte	Minas Gerais
Brazil	AngioCor Blumenau	Blumenau	Santa Catarina
Brazil	Chronos Pesquisa Clínica	Brasília	Distrito Federal
Brazil	L2IP - Instituto de Pesquisas Clínicas - FC072920211954380192	Brasília	Distrito Federal
Brazil	Centro de Endocrinologia Geloneze	Campinas	São Paulo
Brazil	Centro de Pesquisa Sao Lucas	Campinas	São Paulo
Brazil	Instituto de Pesquisa clinica de Campinas	Campinas	São Paulo
Brazil	Instituto de Pesquisas em Saúde (IPS)	Caxias do sul	Rio Grande Do Sul
Brazil	Centro de Diabetes Curitiba	Curitiba	Paraná
Brazil	Cline Research Center	Curitiba	Paraná
Brazil	Instituto Pro Renal Brasil	Curitiba	Paraná
Brazil	Pesquisa Clínica em Diabetes - Dra Rosângela Réa	Curitiba	Paraná
Brazil	PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR	Curitiba	Paraná
Brazil	Instituto de Ensino e Pesquisa Clinica do Ceara	Fortaleza	Ceará
Brazil	Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE	Fortaleza	Ceará
Brazil	Private Practice - Dr.Miguel N. Hissa	Fortaleza	Ceará
Brazil	Universidade Federal de Goias	Goiania	Goiás
Brazil	Centro de Pesquisas Clínicas Dr. Marco Mota	Maceio	Alagoas
Brazil	CPHOSP Manaus Medicina, Ensino e Pesquisa	Manaus	Amazonas
Brazil	Centro de Pesquisa Clínica de Marília - CPCLIM	Marília	São Paulo
Brazil	Instituto Méderi de Pesquisa e Saúde	Passo Fundo	Rio Grande Do Sul
Brazil	Núcleo de Pesquisa Clínica do Rio Grande do Sul	Porto Alegre	Rio Grande Do Sul
Brazil	Hospital Pro-Cardiaco	Rio de Janeiro
Brazil	Hospital São Lucas Copacabana	Rio de Janeiro
Brazil	IBPClin - Instituto Brasil de Pesquisa Clínica	Rio de Janeiro
Brazil	Ruschel Medicina e Pesquisa Clínica	Rio De Janeiro
Brazil	Clinica Senhor do Bonfim CSB - Salvador	Salvador	Bahia
Brazil	Hospital Da Bahia	Salvador	Bahia
Brazil	Praxis Pesquisa Medica	Santo Andre	São Paulo
Brazil	Pesquisare Saude	Santo André	São Paulo
Brazil	Centro Multidisciplinar de Estudos Clinicos	Sao Bernardo do Campo	São Paulo
Brazil	Fundação Faculdade Regional de Medicina de São José do Rio Preto	São José do Rio Preto	São Paulo
Brazil	ISPEM - Instituto São José dos Campos em Pesquisas Médicas	São José dos Campos	São Paulo
Brazil	BR Trials - Ensaios Clinicos e Consultoria	Sao Paulo	São Paulo
Brazil	CPCLIN	Sao Paulo	São Paulo
Brazil	Hospital Alemao Oswaldo Cruz	Sao Paulo	São Paulo
Brazil	Incor - Instituto do Coracao	Sao Paulo	São Paulo
Brazil	Instituto de Pesquisa Clinica	Sao Paulo	São Paulo
Brazil	CEPIC - Centro Paulista de Investigação Clínica	São Paulo
Brazil	CPQuali Pesquisa Clínica	São Paulo
Brazil	Hospital 9 De Julho	São Paulo
Brazil	Hospital BP	São Paulo
Brazil	Hospital das Clinicas FMUSP	São Paulo
Brazil	Núcleo de Pesquisa Clínica da Rede São Camilo	São Paulo
Brazil	Instituto de Molestias Cardiovasculares de Tatui	Tatui	São Paulo
Brazil	Eurolatino Pesquisas Medicas	Uberlandia	Minas Gerais
Brazil	CEDOES	Vitória	Espírito Santo
Brazil	Integral Pesquisa e Ensino	Votuporanga	São Paulo
Canada	C-health Research	Calgary	Alberta
Canada	Ecogene-21	Chicoutimi	Quebec
Canada	Med Trust Research	Courtice	Ontario
Canada	C-health	Edmonton	Alberta
Canada	St Josephs Healthcare Hamilton - West 5th Campus	Hamilton	Ontario
Canada	London Regional Cancer Program	London	Ontario
Canada	St. Joseph's Health Care	London	Ontario
Canada	Western Centre for Public Health and Family Medicine	London	Ontario
Canada	G A Research Associates	Moncton	New Brunswick
Canada	North York Diagnostic and Cardiac Centre	North York	Ontario
Canada	Lakeridge Health	Oshawa	Ontario
Canada	Alpha Recherche Clinique	Quebec
Canada	Unité de Recherche Clinique du CISSS des Laurentides	St-Jerome	Quebec
Canada	Ocean West Research Clinic	Surrey	British Columbia
Canada	SMH Cardiology Clinical Trials	Surrey	British Columbia
Canada	Care Access - Cape Breton	Sydney	Nova Scotia
Canada	Corcare	Toronto	Ontario
Canada	Toronto General Hospital	Toronto	Ontario
Canada	Winchester District Memorial Hospital	Winchester	Ontario
Canada	Seven Oaks General Hospital	Winnipeg	Manitoba
Canada	Winnipeg Clinic	Winnipeg	Manitoba
Czechia	Kardiologicka ambulance	Brandýs nad Labem-Stará Boleslav	Praha-východ
Czechia	Fakultni Nemocnice u sv. Anny v Brne	Brno	Brno-mesto
Czechia	Fakultni Nemocnice u sv. Anny v Brne	Brno	Jihomoravský Kraj
Czechia	UNIVMED	Brno	Brno-mesto
Czechia	Vojenská Nemocnice Brno	Brno	Brno-mesto
Czechia	Nemocnice Cesky Krumlov	Ceský Krumlov
Czechia	Kardio Chlumec	Chlumec nad Cidlinou	Královéhradecký Kraj
Czechia	Kardioma	Kolin	Stredoceský Kraj
Czechia	Kardiologicka ambulance	Litovel	Olomoucký Kraj
Czechia	EDUMED - Náchod	Náchod
Czechia	Agentura Science Pro	Olomouc	Olomoucký Kraj
Czechia	Diabetologicke centrum s.r.o.	Olomouc
Czechia	PreventaMed	Olomouc
Czechia	MaderMED	Ostrava	Moravskoslezský Kraj
Czechia	Private Practice - Dr. Miroslav Koliba	Ostrava	Ostrava Mesto
Czechia	Kardiologicka a Angiologicka Ambulance	Ostrava - Dubina	Moravskoslezský Kraj
Czechia	Centrum Kardiovaskularni Mediciny	Prague	Praha 6
Czechia	Fakultni Thomayerova nemocnice	Prague	Praha 4
Czechia	FLEDIP - Na dlouhem lanu	Prague	Praha, Hlavní Mešto
Czechia	MEDICON	Prague	Praha 4
Czechia	MUDr. Jana Parkanyiova	Prague	Praha 1
Czechia	Nefrologie	Prague	Praha 4
Czechia	Poliklinika Lípa Centrum	Prague	Praha 13
Czechia	Synexus Czech	Prague	Praha 2
Czechia	DiaVize s.r.o.	Praha	Praha 4
Czechia	ResTrial s.r.o.	Praha	Praha 8
Czechia	Diabetologie a endokrinologie, J.Venerová	Praha 6	Praha, Hlavní Mešto
Czechia	MUDr. Barbora Diepoltova	Praha 9 - Klanovice	Praha 9
Czechia	Diakom, s.r.o. - Preštice	Preštice	Plzen-jih
Czechia	Kardiologicka ambulance MUDr. Ferkl s.r.o.	Trutnov
Czechia	Clinical Trials Service s.r.o.	Uherské Hradište	Zlínský Kraj
Czechia	Cardio Research, s.r.o	Zlín
Denmark	Sygehus Sønderjylland i Aabenraa	Aabenraa	Syddanmark
Denmark	Aarhus Universitetshospital, Skejby	Aarhus	Midtjylland
Denmark	Herlev and Gentofte Hospital	Copenhagen	Hovedstaden
Denmark	Sanos Clinic - Nordjylland	Gandrup	Nordjylland
Denmark	Sanos Clinic	Herlev	Hovedstaden
Denmark	Sanos Clinic - Syddanmark	Vejle	Syddanmark
France	Bordeaux University Hospital - Pellegrin	Bordeaux	Aquitaine
France	Chu Gabriel Montpied	Clermont-Ferrand	Puy-de-Dôme
France	Centre Hospitalier Sud Francilien	Corbeil-Essonnes	Île-de-France
France	Chu Grenoble Alpes	La Tronche	Isère
France	Centre Hospitalier Louis Pasteur	Le Coudray	Eure-et-Loir
France	CHU Montpellier Lapeyronie Hospital	Montpellier	Hérault
France	Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes	Nantes Cedex 1	Loire-Atlantique
France	CHU de Nice	Nice	Alpes-Maritimes
France	Groupe hospitalier Paris saint Joseph	Paris	Île-de-France
France	Hôpital Européen Georges Pompidou	Paris	Île-de-France
France	Pitie Salpetriere University Hospital	Paris	Orne
France	CHU Bordeaux Haut-Leveque	Pessac	Aquitaine
France	CHU Rangueil	Toulouse cedex 9	Haute-Garonne
France	Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau	Tours	Indre-et-Loire
France	Polyclinique Vauban	Valenciennes	Nord
Germany	Kerckhoff-Klinik	Bad Nauheim	Hessen
Germany	Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen	Bad Oeynhausen	Nordrhein-Westfalen
Germany	emovis GmbH	Berlin
Germany	Kardiologisch-Angiologische Praxis - Herzzentrum Bremen	Bremen
Germany	Kath. St.-Johannes-Gesellschaft Dortmund	Dortmund	Nordrhein-Westfalen
Germany	Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien	Dresden	Sachsen
Germany	Universitaetsklinikum Carl Gustav Carus Dresden	Dresden	Sachsen
Germany	ZKS Suedbrandenburg	Elsterwerda	Brandenburg
Germany	InnoDiab Forschung Gmbh	Essen	Nordrhein-Westfalen
Germany	Unterfrintroper Hausarztzentrum Klinische Forschung	Essen	Nordrhein-Westfalen
Germany	Universitätsklinikum Frankfurt	Frankfurt	Hessen
Germany	Diabetes Zentrum Wandsbek	Hamburg
Germany	Diabetes Zentrum Wilhelmsburg	Hamburg
Germany	Zentrum für Nieren-, Hochdruck- und Stoffwechselerkrankungen - Heidering	Hannover	Niedersachsen
Germany	AmBeNet GmbH	Leipzig	Sachsen
Germany	Universität zu Lübeck - Institut für Endokrinologie und Diabetes	Lübeck	Schleswig-Holstein
Germany	Universitätsmedizin Johannes Gutenberg Universität Mainz	Mainz	Rheinland-Pfalz
Germany	CRS Clinical Research Services Mannheim	Mannheim	Baden-Württemberg
Germany	Universitätsmedizin Mannheim	Mannheim	Baden-Württemberg
Germany	Institut für Diabetesforschung GmbH Münster	Münster	Nordrhein-Westfalen
Germany	RED-Institut GmbH	Oldenburg	Schleswig-Holstein
Germany	Kardiologische Praxis Papenburg	Papenburg	Niedersachsen
Germany	Zentrum für klinische Studien	Saint Ingbert	Saarland
Germany	Nephrologisches Zentrum Villingen-Schwenningen	Villingen-Schwenningen	Baden-Württemberg
Germany	Praxis Sauter & Sauter & Vorbach	Wangen im Allgäu	Baden-Württemberg
Greece	Athens Medical Center	Athens	Attikí
Greece	Athens Medical Center - Psychikon branch	Athens	Attikí (Region)
Greece	General Hospital of Athens "G. Gennimatas"	Athens	Attikí
Greece	General Hospital of Athens Laiko	Athens	Attikí
Greece	University Hospital of Ioannina	Ioannina	Ípeiros
Greece	University General Hospital of Larissa	Larissa	Thessalía
Greece	Iatriko Paleou Falirou Medical Center	Paleo Faliro	Attikí (Region)
Greece	424 Military General Training Hospital	Thessaloniki	Thessaloníki
Greece	Euromedica General Clinic of Thessaloniki	Thessaloniki	Thessaloníki
Greece	G. Gennimatas General Hospital of Thessaloniki	Thessaloniki	Thessaloníki
Greece	Papageorgiou General Hospital of Thessaloniki	Thessaloniki	Thessaloníki
Hungary	DRC Gyógyszervizsgáló Központ	Balatongyorok	Veszprém
Hungary	Magyar Honvedseg Egeszsegugyi Kozpont	Budapest
Hungary	Óbudai Egészségügyi Centrum	Budapest
Hungary	Privát Doktor Egészségügyi Zrt	Budapest
Hungary	PVN Kutató Kft	Budapest
Hungary	Semmelweis University	Budapest
Hungary	Szent Margit Rendelointézet Nonprofit Kft	Budapest
Hungary	Újpesti Egészségügyi Nonprofit Kft	Budapest
Hungary	Debreceni Egyetem Klinikai Kozpont	Debrecen
Hungary	CRU Early Phase Unit	Kistarcsa	Pest
Hungary	Selye János Kórház	Komarom	Komárom-Esztergom
Hungary	Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ	Szeged	Csongrád
Hungary	Allergo-Derm Bakos Kft	Szolnok	Jász-Nagykun-Szolnok
Hungary	Zala Megyei Szent Rafael Kórház	Zalaegerszeg	Zala
India	Motilal Nehru Medical College Hospital	Allahabad	Uttar Pradesh
India	Life Care Hospital and Research Centre	Bangalore	Karnataka
India	All India Institute of Medical Sciences	Bhubaneswar	Odisha
India	Medway Hospitals - Kodambakkam	Chennai	Tamil Nadu
India	S C B Medical College and Hospital	Cuttack	Odisha
India	Shri Mahant Indiresh Hospital	Dehradun	Uttarakhand
India	K care Hospital	Kanpur	Uttar Pradesh
India	LPS Institute of Cardiology	Kanpur	Uttar Pradesh
India	Government Medical College - Kozhikode	Kozhikode	Kerala
India	Dr. Ram Manohar Lohia Institute of Medical Sciences	Lucknow	Uttar Pradesh
India	Manipal Hospitals	Mysore	Karnataka
India	All India Institute of Medical Sciences (AIIMS) - Nagpur	Nagpur	Maharashtra
India	Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)	Nagpur	Maharashtra
India	Shrikrishna Hrudayalaya And Critical Care Center	Nagpur	Maharashtra
India	All India Institute of Medical Sciences	New Delhi	Delhi
India	G.B. Pant Institute of Postgraduate Medical Education & Research	New Delhi	Delhi
India	Sir Ganga Ram Hospital	New Delhi	Delhi
India	All India Institute of Medical Sciences	Raipur	Chhattisgarh
India	Nirmal Hospital	Surat	Gujarat
India	Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute	Surat	Gujarat
Israel	Barzilai Medical Center	Ashkelon	HaDarom
Israel	Bnai Zion Medical Center	Haifa	HaTsafon
Israel	Rambam Health Care Campus	Haifa	HaTsafon
Israel	Hadassah Medical Center	Jerusalem	Yerushalayim
Israel	Shaare Zedek Medical Center	Jerusalem	Yerushalayim
Israel	Galilee Medical Center	Nahariya	HaTsafon
Israel	Rabin Medical Center - Hasharon Campus	Petach Tikva	HaMerkaz
Israel	Rabin Medical Center	Petah Tikva	HaMerkaz
Israel	Rabin Medical Center	Petah-Tikva	HaMerkaz
Israel	Sheba Medical Center	Ramat Gan	HaMerkaz
Israel	Sheba Medical Center	Ramat Gan	HaMerkaz
Israel	Kaplan Medical Center	Rehovot	HaMerkaz
Israel	Diabetes Medical Center	Tel Aviv	HaMerkaz
Israel	Sourasky Medical Center	Tel Aviv	Tell Abib
Israel	Yitzhak Shamir Medical Center	Zerifin	HaMerkaz
Italy	Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII	Bergamo
Italy	IRCCS - AOU di Bologna	Bologna
Italy	Azienda Ospedaliero Universitaria S.Anna	Ferrara	Emilia-Romagna
Italy	Ospedale San Martino	Genova	Liguria
Italy	Centro Cardiologico Monzino	Milan	Milano
Italy	Ospedale San Raffaele	Milano
Italy	A.O.U. Policlinico Paolo Giaccone	Palermo	Sicilia
Italy	AO Santa Maria della Misericordia	Perugia	Umbria
Italy	Azienda Ospedaliera Universitaria Pisana	Pisa	Toscana
Italy	Azienda Ospedaliera Universitaria Pisana	Pisa	Toscana
Italy	Fondazione Policlinico Universitario Agostino Gemelli	Roma
Italy	Policlinico Universitario Campus Bio-Medico	Rome	Roma
Italy	IRCCS Policlinico San Donato	San Donato Milanese	Milano
Mexico	Centro de Atencion al Diabetico Actopan	Actopan	Hidalgo
Mexico	Fundación Cardiovascular de Aguascalientes A.C.	Aguascalientes
Mexico	Enclifar Ensayos Clínicos Farmacológicos Sc	Chihuahua
Mexico	Centro de Estudios de Investigacion Metabolicos y Cardiovasculares	Ciudad Madero	Tamaulipas
Mexico	Cryptex Investigación Clínica S.A. de C.V.	Cuauhtémoc, Ciudad De México	Distrito Federal
Mexico	Instituto de Diabetes, Obesidad y Nutricion	Cuernavaca	Morelos
Mexico	Investigación Nefrológica	Cuernavaca	Morelos
Mexico	PanAmerican Clinical Research - Cuernavaca	Cuernavaca	Morelos
Mexico	Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.	Culiacan	Sinaloa
Mexico	Instituto de Investigaciones Aplicadas a la Neurociencia A.C.	Durango
Mexico	Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia	Durango
Mexico	Centro de Investigación Clínica y Medicina Traslacional (CIMeT)	Guadalajara	Jalisco
Mexico	Centro de Investigacion Medica Integral	Guadalajara	Jalisco
Mexico	CINVEC Medica	Guadalajara	Jalisco
Mexico	Diseno y Planeacion en Investigacion Medica	Guadalajara	Jalisco
Mexico	Instituto Jalisciense de Investigacion en Diabetes y Obesidad	Guadalajara	Jalisco
Mexico	Private Practice - Dr. Arechavaleta Granell Maria del Rosario	Guadalajara	Jalisco
Mexico	Unidad de Investigación Clínica y Atención Médica HEPA	Guadalajara	Jalisco
Mexico	Virgen Cardiovascular Research SC	Guadalajara	Jalisco
Mexico	Instituto Cardiovascular de León S.C.	León	Guanajuato
Mexico	Medical Care and Research SA de CV	Merida	Yucatán
Mexico	EME RED Hospitalaria	Mérida	Yucatán
Mexico	Centro de Investigacion en Artritis y Osteoporosis SC	Mexicali	Baja California
Mexico	Clinstile, S.A. de C.V.	Mexico	Distrito Federal
Mexico	Instituto Nacional de Cardiologia Ignacio Chavez	Mexico
Mexico	Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares	Mexico City	Distrito Federal
Mexico	Clinica Omega	Mexico City	Distrito Federal
Mexico	Clínicos Asociados BOCM	Mexico City	Distrito Federal
Mexico	Hospital de Jésus, I.A.P.	Mexico City	Distrito Federal
Mexico	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran	Mexico City	Distrito Federal
Mexico	ProcliniQ Investigación Clínica SA de CV	Mexico City	Distrito Federal
Mexico	RM Pharma Specialists	Mexico City	Distrito Federal
Mexico	Cardiolink Clin Trials	Monterrey	Nuevo León
Mexico	Centro de investigación y control metabólico	Monterrey	Nuevo León
Mexico	Clínica García Flores SC	Monterrey	Nuevo León
Mexico	Hospital Universitario "Dr. Jose Eleuterio Gonzalez"	Monterrey	Nuevo León
Mexico	IMED Internal Medicine Clin Trials	Monterrey	Nuevo León
Mexico	Servicios de Oncología Medica Integral - Monterrey - José Benitez	Monterrey	Nuevo León
Mexico	Unidad biomedica avanzada monterrey	Monterrey	Nuevo León
Mexico	Clinica de Enfermedades Crónicas y de Procedimientos Especiales	Morelia	Michoacán
Mexico	Centro de Investigacion Clinica de Oaxaca	Oaxaca de Juarez	Oaxaca
Mexico	Boca Clinical Trials Mexico SC	Puebla
Mexico	Centro de Estudios Clínicos de Querétaro (CECLIQ)	Querétaro
Mexico	PanAmerican Clinical Research - Querétaro - Avenida Antea	Querétaro
Mexico	Centro de Atención e Investigación Cardiovascular del Potosí	San Luis Potosí
Mexico	Centro de Investigacion Cardiovascular y Metabólica	Tijuana	Baja California
Mexico	Medimanage Research	Tlalpan	Distrito Federal
Mexico	Arké SMO S.A de C.V	Veracruz
Mexico	FAICIC S. de R.L. de C.V.	Veracruz
Mexico	Instituto Veracruzano en Investigación Clínica S.C.	Veracruz
Mexico	Consultorio de Medicina Especilizada del Sector Privado	Xalapa	Veracruz
Netherlands	Noordwest Ziekenhuisgroep	Alkmaar	Noord-Holland
Netherlands	Emotional Brain FlevoResearch	Almere	Flevoland
Netherlands	Meander Medisch Centrum	Amersfoort	Utrecht
Netherlands	Amsterdam UMC, locatie AMC	Amsterdam	Noord-Holland
Netherlands	Onze Lieve Vrouwe Gasthuis	Amsterdam	Noord-Holland
Netherlands	Gelre Ziekenhuis	Apeldoorn	Gelderland
Netherlands	Rode Kruis Ziekenhuis	Beverwijk	Noord-Holland
Netherlands	Amphia Ziekenhuis, locatie Breda Molengracht	Breda	Noord-Brabant
Netherlands	Huisartsenpraktijk Disha	Den Haag
Netherlands	Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland	Dirksland	Zuid-Holland
Netherlands	Albert Schweitzer Ziekenhuis, locatie Dordwijk	Dordrecht	Zuid-Holland
Netherlands	Ziekenhuis Gelderse Vallei	Ede	Gelderland
Netherlands	Catharina Ziekenhuis	Eindhoven	Noord-Brabant
Netherlands	Medisch Spectrum Twente	Enschede	Overijssel
Netherlands	Spaarne Gasthuis, Haarlem Zuid	Haarlem	Noord-Holland
Netherlands	Atrium-Orbis - Zuyderland Medisch Centrum Heerlen	Heerlen	Limburg
Netherlands	Ziekenhuis Bethesda	Hoogeveen	Drenthe
Netherlands	Medische Centrum Leeuwarden	Leeuwarden	Fryslân
Netherlands	Canisius-Wilhelmina Ziekenhuis	Nijmegen	Gelderland
Netherlands	Radboudumc	Nijmegen	Gelderland
Netherlands	Bravis Ziekenhuis, locatie Roosendaal	Roosendaal	Noord-Brabant
Netherlands	Franciscus Gasthuis & Vlietland, Locatie Gasthuis	Rotterdam	Zuid-Holland
Netherlands	Medisch Centrum Thomsonplein	The Hague	Zuid-Holland
Netherlands	Ziekenhuis Rivierenland	Tiel	Gelderland
Netherlands	Universitair Medisch Centrum Utrecht	Utrecht
Netherlands	VieCuri Medisch Centrum, locatie Venlo	Venlo	Limburg
Netherlands	Dokters van Nederhoven	Zwijndrecht
Netherlands	Huisartsenpraktijk Broekman	Zwijndrecht	Zuid-Holland
Netherlands	Isala, locatie Zwolle	Zwolle	Overijssel
Poland	KLIMED Marek Klimkiewicz	Bialystok	Podlaskie
Poland	Polsko-Amerykanskie Kliniki Serca II Oddzial Kardiologiczny	Bielsko-Biala	Slaskie
Poland	INTERCOR	Bydgoszcz	Kujawsko-pomorskie
Poland	NZOZ Centrum Medyczne KERmed	Bydgoszcz	Kujawsko-pomorskie
Poland	Diab Serwis Popenda Spólka Jawna	Chorzow	Slaskie
Poland	Polsko-Amerykanskie Kliniki Serca PAKS Malopolskie Centrum Sercowo-Naczyniowe	Chrzanow	Malopolskie
Poland	Centrum Kliniczno-Badawcze	Elblag	Warminsko-mazurskie
Poland	Uniwersyteckie Centrum Kliniczne	Gdansk	Pomorskie
Poland	NZOZ Diab-Endo-Met	Krakow	Malopolskie
Poland	Poliklinika Kardiologiczna Serce	Leszno	Wielkopolskie
Poland	Pro Salus Centrum Medyczne	Lodz	Lódzkie
Poland	CenterMed Lublin NZOZ	Lublin	Lubelskie
Poland	Ekamed	Lublin	Lubelskie
Poland	EndoPractica	Opole	Opolskie
Poland	Centrum Zdrowia Metabolicznego Pawel Bogdanski	Poznan	Wielkopolskie
Poland	Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu	Przemysl	Podkarpackie
Poland	Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Zabówka E. Zabówka	Tarnow	Malopolskie
Poland	Polsko-Amerykanskie Kliniki Serca	Tychy	Slaskie
Poland	Balsam Medica	Warsaw	Mazowieckie
Poland	NZOZ Centurm Medyczne SERAFIN-MED	Zarow	Dolnoslaskie
Puerto Rico	Advanced Clinical Research, LLC	Bayamón
Puerto Rico	GCM Medical Group, PSC - Hato Rey Site	San Juan
Romania	CMI DNBM Dr. Pop Lavinia	Baia Mare	Maramure?
Romania	Private Practice - Dr. Mercea Corina Delia	Baia Mare	Maramure?
Romania	C.M.D.T.A. Neomed	Brasov	Bra?ov
Romania	Centrul Medical Endocrinologie si Diabet Dr. Paveliu	Bucharest	Bucure?ti
Romania	Centrul Medical NutriLife	Bucharest	Bucure?ti
Romania	Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului	Bucharest	Bucure?ti
Romania	Nicodiab	Bucharest	Bucure?ti
Romania	Spitalul Clinic Jude?ean de Urgen?a	Craiova	Dolj
Romania	Diamed Obesity	Gala?i
Romania	Milena Sante	Gala?i
Romania	Cardiomed Ia?i	Ia?i
Romania	Centrul Medical Consultmed	Ia?i
Romania	Clinica Korall	Satu Mare
Romania	Policlinica Astra Sibiu	Sibiu
Romania	SC Dentosim Queen SRL - Centrul Medical Diamed	Târgu Mure?	Mure?
Romania	Centrul Medical Mediab	Târgu-Mure?	Mure?
Romania	Centrul Medical Mediab	Târgu-Mure?	Mure?
Romania	Institutul de Boli Cardiovasculare Timi?oara	Timi?oara	Timi?
Romania	Cabinet Medical Dr.Geru	Timisoara	Timi?
Romania	Centrul Medical Medicalis	Timisoara	Timi?
Slovakia	Cliniq s.r.o.	Bratislava	Bratislavský Kraj
Slovakia	ENDIAMED s.r.o	Dolny Kubin	Žilinský Kraj
Slovakia	JM-Interna s.r.o	Dolny Kubin	Žilinský Kraj
Slovakia	NEDÚ - Národný endokrinologický a diabetologický ústav n.o.	Lubochna	Žilinský Kraj
Slovakia	IN-DIA	Lucenec	Banskobystrický Kraj
Slovakia	Nemocnica s poliklinikou Lucenec	Lucenec	Banskobystrický Kraj
Slovakia	Sin Azucar	Malacky	Bratislavský Kraj
Slovakia	AMBORA s.r.o. Interna ambulancia	Martin	Žilinský Kraj
Slovakia	Fakultná nemocnica Nitra	Nitra	Nitriansky Kraj
Slovakia	Funkystuff	Nove Zamky	Nitriansky Kraj
Slovakia	MEDIKALS	Pieštany	Trnavský Kraj
Slovakia	MUDr. Judita Gondova	Poltar	Banskobystrický Kraj
Slovakia	ENRIN, s.r.o.	Rimavská Sobota	Banskobystrický Kraj
Slovakia	Tatratrial s.r.o.	Rožnava	Košický Kraj
Slovakia	Areteus s.r.o.	Trebisov	Košický Kraj
Slovakia	MediPrax, s.r.o.	Trstena	Žilinský Kraj
Slovakia	B-Medical, s.r.o.	Tvrdošín	Žilinský Kraj
Slovakia	IRIDIA	Vrutky	Žilinský Kraj
Spain	CHUAC-Complejo Hospitalario Universitario A Coruña	A Coruña	A Coruña [La Coruña]
Spain	Centro Periférico de Especialidades Bola Azul	Almeria	Almería
Spain	Hospital Universitario de La Ribera	Alzira	Valenciana, Comunitat
Spain	Hospital Universitari Vall d'Hebron	Barcelona	Barcelona [Barcelona]
Spain	Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval	Ferrol	A Coruña [La Coruña]
Spain	Hospital Universitario Virgen de la Victoria	Malaga	Andalucía
Spain	Hospital Universitario Central de Asturias	Oviedo	Asturias, Principado De
Spain	Clínica Juaneda	Palma de Mallorca	Balears [Baleares]
Spain	Hospital Universitario Quironsalud Madrid	Pozuelo de Alarcón	Madrid
Spain	Hospital Universitario Marqués de Valdecilla	Santander	Cantabria
Spain	Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)	Sevilla
Spain	Hospital Quiron Infanta Luisa	Sevilla	Andalucía
Spain	Vithas Hospital Sevilla	Seville	Sevilla
Spain	Hospital Universitario Doctor Peset	Valencia	València
Turkey	Adana Sehir Egitim ve Arastirma Hastanesi	Adana
Turkey	Afyon Kocatepe Üniversitesi Tip Fakültesi	Afyonkarahisar
Turkey	Ankara Bilkent Sehir Hastanesi	Ankara
Turkey	Hacettepe Universitesi	Ankara
Turkey	Akdeniz Universitesi Hastanesi	Antalya
Turkey	T.C. Saglik Bakanligi - Hitit Universitesi Corum Egitim ve Arastirma Hastanesi	Corum
Turkey	Trakya University	Edirne
Turkey	Eskisehir Osmangazi University	Eskisehir	Eskisehir
Turkey	Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi	Gaziantep
Turkey	Dr. Siyami Ersek Gögüs Kalp Ve Damar Cerrahisi Egitim Ve Arastirma Hastanesi	Istanbul
Turkey	Kartal Kosuyolu Yüksek Ihtisas Egitim ve Arastirma Hastanesi	Istanbul
Turkey	Istanbul Universitesi Cerrahpasa	Istanbul- Fatih	Istanbul
Turkey	Ege Universitesi Hastanesi	Izmir
Turkey	Erciyes Universitesi Tip Fakultesi Hastaneleri	Kayseri
Turkey	Kocaeli Üniversitesi	Kocaeli
Turkey	Ophthalmology	Kocaeli
Turkey	Necmettin Erbakan University Meram Medical Faculty ; Internal Diseases	Meram	Konya
Turkey	Mersin University	Mersin
Turkey	Cumhuriyet Universitesi	Sivas
Turkey	Bursa Yüksek Ihtisas Egitim Ve Arastirma Hastanesi	Yildirim	Bursa
United Kingdom	Aberdeen Royal Infirmary	Aberdeen	Aberdeen City
United Kingdom	FutureMeds - Birmingham	Birmingham
United Kingdom	FutureMeds - Liverpool	Bromborough	Wirral
United Kingdom	University Hospital Coventry & Warwickshire	Coventry
United Kingdom	Hull and East Yorkshire Hospitals NHS Trust	Hull	Kingston Upon Hull
United Kingdom	Ipswich Hospital	Ipswich	Suffolk
United Kingdom	Royal London Hospital	London	England
United Kingdom	Newquay Health Centre	Newquay	Cornwall
United Kingdom	Homecroft Surgery	Redruth	Cornwall
United Kingdom	Swansea University	Swansea	Swansea [Abertawe Gb-ata]
United Kingdom	Musgrove Park Hospital	Taunton	Somerset
United Kingdom	Rame Medical Ltd	Torpoint	Cornwall
United States	American Clinical Trials - Acworth	Acworth	Georgia
United States	Golden Hearts Diagnostic	Alamogordo	New Mexico
United States	Albany Medical College, Division of Community Endocrinology	Albany	New York
United States	Cambridge Medical Trials	Alexandria	Louisiana
United States	Alaska Heart and Vascular Institute	Anchorage	Alaska
United States	Kidney & Hypertension Center - Apple Valley	Apple Valley	California
United States	Atlanta Diabetes Associates	Atlanta	Georgia
United States	Emory University School of Medicine	Atlanta	Georgia
United States	Fides Clinical Research	Atlanta	Georgia
United States	Southeastern Clinical Research Institute	Augusta	Georgia
United States	University of Colorado Anschutz Medical Campus	Aurora	Colorado
United States	IMA Clinical Research Austin	Austin	Texas
United States	Care Access - Baltimore	Baltimore	Maryland
United States	Maryland Cardiovascular Specialists	Baltimore	Maryland
United States	MedStar Good Samaritan Hospital	Baltimore	Maryland
United States	Sinai Hospital Of Baltimore	Baltimore	Maryland
United States	Heritage Valley Medical Group, Inc.	Beaver	Pennsylvania
United States	Jadestone Clinical Research	Beltsville	Maryland
United States	AHF Westside	Beverly Hills	California
United States	American Institute of Research	Beverly Hills	California
United States	Central Research Associates	Birmingham	Alabama
United States	Excel Medical Clinical Trials	Boca Raton	Florida
United States	Joslin Diabetes Center	Boston	Massachusetts
United States	Qualmedica Research	Bowling Green	Kentucky
United States	Headlands Research - Brownsville	Brownsville	Texas
United States	Mercury Street Medical Group, PLLC	Butte	Montana
United States	Capital Area Research, LLC	Camp Hill	Pennsylvania
United States	Hope Clinical Research, Inc.	Canoga Park	California
United States	Accellacare Trident Cardiology	Charleston	South Carolina
United States	Medical University of South Carolina	Charleston	South Carolina
United States	Great Lakes Clinical Trials - Ravenswood	Chicago	Illinois
United States	Alpine Research Organization	Clinton	Utah
United States	South Texas Clinical Research	Corpus Christi	Texas
United States	Good Samaritan Regional Medical Center	Corvallis	Oregon
United States	Valley Clinical Trials, Inc.	Covina	California
United States	Baylor Soltero CV Research Center	Dallas	Texas
United States	Dallas Diabetes Research Center	Dallas	Texas
United States	North Texas Endocrine Center	Dallas	Texas
United States	Renal Disease Research Institute	Dallas	Texas
United States	UT Southwestern Medical Center	Dallas	Texas
United States	Geisinger Medical Center	Danville	Pennsylvania
United States	Alliance for Multispecialty Research, LLC	Daphne	Alabama
United States	Alliance for Multispecialty Research, LLC.	Dearborn	Michigan
United States	Revival Research Institute - Dearborn	Dearborn	Michigan
United States	Soma Clinical Trials	Denison	Texas
United States	Care Access - Dorchester	Dorchester	Massachusetts
United States	American Clinical Trials - Douglasville	Douglasville	Georgia
United States	South Texas Research Institute	Edinburg	Texas
United States	El Paso Medical Research Institute	El Paso	Texas
United States	North Coast Cardiology	Encinitas	California
United States	Neighborhood Healthcare Institute of Health	Escondido	California
United States	Qualmedica Research, LLC	Evansville	Indiana
United States	The University of Kansas - Clinical Research Center	Fairway	Kansas
United States	NECCR PrimaCare Research	Fall River	Massachusetts
United States	Care Access - Fayetteville	Fayetteville	North Carolina
United States	Fleming Island Center for Clinical Research	Fleming Island	Florida
United States	Florida Kidney Physicians - Fort Lauderdale	Fort Lauderdale	Florida
United States	Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care	Fort Lauderdale	Florida
United States	Diabetes and Thyroid Center of Ft. Worth	Fort Worth	Texas
United States	Valley Institute of Research - Fort Worth	Fort Worth	Texas
United States	HB Clinical Trials - Fountain Valley	Fountain Valley	California
United States	Center for Advanced Research & Education	Gainesville	Georgia
United States	Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC	Gilbert	Arizona
United States	St. Vincent Hospital d/b/a Prevea Health	Green Bay	Wisconsin
United States	Medication Management	Greensboro	North Carolina
United States	Physician's East Endocrinology	Greenville	North Carolina
United States	Clinical Investigation Specialists	Gurnee	Illinois
United States	Henderson Clinical Trials	Henderson	Nevada
United States	Amir A Hassan, MD, PA	Houston	Texas
United States	Aqua Research Institute	Houston	Texas
United States	Biopharma Informatic, LLC	Houston	Texas
United States	Clinical Trial Network	Houston	Texas
United States	Endocrine Ips, Pllc	Houston	Texas
United States	Juno Research	Houston	Texas
United States	Northwest Houston Cardiology - Cypress	Houston	Texas
United States	Accurate Clinical Research, Inc	Humble	Texas
United States	Care Access Research - Huntington Beach	Huntington Beach	California
United States	Nephrology Consultants	Huntsville	Alabama
United States	MedStar Health Research Institute (MedStar Physician Based Research Network)	Hyattsville	Maryland
United States	Indiana University Health Methodist Hospital	Indianapolis	Indiana
United States	Irvine Clinical Research	Irvine	California
United States	East Coast Institute for Research, LLC	Jacksonville	Florida
United States	The Center for Pharmaceutical Research	Kansas City	Missouri
United States	Clinical Investigation Specialists	Kenosha	Wisconsin
United States	Marian David, MD, P.C.	Kew Gardens	New York
United States	Westchester Medical Center Advanced Physicians Service	Kingston	New York
United States	Alliance for Multispecialty Research, LLC	Knoxville	Tennessee
United States	Scripps Whittier Diabetes Institute	La Jolla	California
United States	Care Access - Lake Charles	Lake Charles	Louisiana
United States	Long Island Cardiovascular Consultants	Lake Success	New York
United States	Lancaster General Hospital	Lancaster	Pennsylvania
United States	Advanced Biomedical Research of America - South Eastern Avenue	Las Vegas	Nevada
United States	Alliance for Multispecialty Research, LLC	Las Vegas	Nevada
United States	DaVita Clinical Research - Las Vegas	Las Vegas	Nevada
United States	Excel Clinical Research, LLC	Las Vegas	Nevada
United States	Alliance for Multispecialty Research, LLC	Layton	Utah
United States	IMA Clinical Research - Lenoir	Lenoir	North Carolina
United States	Alliance for Multispecialty Research, LLC	Lexington	Kentucky
United States	Walker Family Care	Little River	South Carolina
United States	Cardiology and Medicine Clinic	Little Rock	Arkansas
United States	Accellacare - DuPage	Lombard	Illinois
United States	Ark Clinical Research	Long Beach	California
United States	Long Beach Research Institute	Long Beach	California
United States	Cedars-Sinai Medical Center	Los Angeles	California
United States	L-MARC Research Center	Louisville	Kentucky
United States	Texas Institute for Kidney and Endocrine Disorders	Lufkin	Texas
United States	North America Research Institute	Lynwood	California
United States	East Coast Institute for Research, LLC	Macon	Georgia
United States	Care Access - Mauldin	Mauldin	South Carolina
United States	Wellness Clinical Research	McKinney	Texas
United States	Care Access - Memphis	Memphis	Tennessee
United States	PRX Research	Mesquite	Texas
United States	Southern Endocrinology Associates	Mesquite	Texas
United States	New Age Medical Research Corporation	Miami	Florida
United States	Suncoast Research Group	Miami	Florida
United States	Inpatient Research Clinic	Miami Lakes	Florida
United States	Boeson Research MSO	Missoula	Montana
United States	Alliance for Multispecialty Research, LLC	Mobile	Alabama
United States	IMA Clinical Research Monroe - Armand	Monroe	Louisiana
United States	West Clinical Research	Morehead City	North Carolina
United States	Exemplar Research	Morgantown	West Virginia
United States	Alliance for Multispecialty Research, LLC	New Orleans	Louisiana
United States	Icahn School of Medicine at Mount Sinai	New York	New York
United States	NYU Langone Health	New York	New York
United States	Alliance for Multispecialty Research, LLC	Newton	Kansas
United States	Alliance for Multispecialty Research, LLC	Norfolk	Virginia
United States	Intend Research, LLC	Norman	Oklahoma
United States	South Carolina Clinical Research LLC	Orangeburg	South Carolina
United States	Elixia Central Florida	Orlando	Florida
United States	Omega Research Orlando	Orlando	Florida
United States	Desert Oasis Healthcare Medical Group	Palm Springs	California
United States	Helios Clinical Research - SAZ-PDV-026	Paradise Valley	Arizona
United States	Alliance for Multispecialty Research, LLC	Park Ridge	Illinois
United States	California Liver Research Institute	Pasadena	California
United States	AMZERN Clinical Trial Organization	Peoria	Arizona
United States	Tristar Clinical Investigations	Philadelphia	Pennsylvania
United States	Absolute Clinical Research	Phoenix	Arizona
United States	Arizona Cardiovascular Research Center	Phoenix	Arizona
United States	Banner University Medical Center Phoenix	Phoenix	Arizona
United States	Elite Clinical Studies	Phoenix	Arizona
United States	Phoenix Clinical LLC	Phoenix	Arizona
United States	Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair	Pittsburgh	Pennsylvania
United States	Western University of Health Sciences	Pomona	California
United States	Elixia MKC, LLC	Pontiac	Michigan
United States	Florida Kidney Physicians - Port Charlotte	Port Charlotte	Florida
United States	Accellacare - Raleigh	Raleigh	North Carolina
United States	Eastside Research Associates	Redmond	Washington
United States	Reid Physician Associates	Richmond	Indiana
United States	Northwell Health Physician Peconic	Riverhead	New York
United States	Florida Kidney Physicians - Tampa	Riverview	Florida
United States	StudyMetrix Research	Saint Peters	Missouri
United States	Synexus Clinical Research US, Inc.	Salt Lake City	Utah
United States	Utah Kidney Research Institute	Salt Lake City	Utah
United States	Clinical Advancement Center	San Antonio	Texas
United States	Diagnostics Research Group	San Antonio	Texas
United States	Discovery Clinical Trials - San Antonio	San Antonio	Texas
United States	Endeavor Clinical Trials	San Antonio	Texas
United States	National Institute of Clinical Research (NICR) - San Antonio - South Laredo Street	San Antonio	Texas
United States	California Kidney Specialists	San Dimas	California
United States	Southern California Dermatology, Inc.	Santa Ana	California
United States	Care Access - Santa Clarita	Santa Clarita	California
United States	Saratoga Clinical Research	Saratoga Springs	New York
United States	Guthrie Medical Group, P.C.	Sayre	Pennsylvania
United States	Scottsdale Clinical Trials	Scottsdale	Arizona
United States	St. Clair Nephrology	Shelby	Michigan
United States	DaVita Clinical Research - North Houston	Shenandoah	Texas
United States	Revival Research Institute, LLC	Sherman	Texas
United States	Millennium Clinical Trials	Simi Valley	California
United States	Circle Clinical Research	Sioux Falls	South Dakota
United States	Encompass Clinical Research	Spring Valley	California
United States	Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative	Springfield	Illinois
United States	Clinvest Research LLC	Springfield	Missouri
United States	Mercy Research - Smith Glynn Callaway	Springfield	Missouri
United States	Cardiology Associates of Fairfield County, P.C.	Stamford	Connecticut
United States	Staten Island University Hospital	Staten Island	New York
United States	Stony Brook University	Stony Brook	New York
United States	Universal Research Group	Tacoma	Washington
United States	Care Access - Tamarac	Tamarac	Florida
United States	Care Access - Tampa	Tampa	Florida
United States	Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research	Tampa	Florida
United States	Valiance Clinical Research	Tarzana	California
United States	Care Access - Thousand Oaks	Thousand Oaks	California
United States	Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.	Toluca Lake	California
United States	Cotton O'Neil Clinical Research Center	Topeka	Kansas
United States	Cotton O'Neil Clinical Research Center - Central Office	Topeka	Kansas
United States	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Torrance	California
United States	UCLA South Bay Endocrinology	Torrance	California
United States	Arcturus Healthcare , PLC, Troy Internal Medicine Research Division	Troy	Michigan
United States	Synexus Clinical Research US, Inc./Orange Grove Family Practice	Tucson	Arizona
United States	Clinical Renal Associates - Panoramic Science	Upland	Pennsylvania
United States	InvivoCure	Van Nuys	California
United States	National Institute of Clinical Research (NICR) - High Desert	Victorville	California
United States	Synexus Clinical Research US - Vista	Vista	California
United States	Chase Medical Research, LLC	Waterbury	Connecticut
United States	Iowa Diabetes and Endocrinology Research Center	West Des Moines	Iowa
United States	Accellacare - Wilmington - 1917 Tradd Court	Wilmington	North Carolina
United States	North Georgia Clinical Research	Woodstock	Georgia
United States	Medrasa Clinical Research	Wylie	Texas

Sponsors (1)

Lead Sponsor	Collaborator
Eli Lilly and Company

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Canada,  Czechia,  Denmark,  France,  Germany,  Greece,  Hungary,  India,  Israel,  Italy,  Mexico,  Netherlands,  Poland,  Puerto Rico,  Romania,  Slovakia,  Spain,  Turkey,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to First Occurrence of Composite Endpoints	A composite endpoint includes nonfatal myocardial infarction (MI), nonfatal stroke, cardiovascular (CV) death, or hospitalization or urgent visit due to heart failure (HF).	Randomization up to Study Completion (Approximate 248 Weeks)
Primary	Time to First Occurrence of Composite Endpoint of End Stage Kidney Disease (ESKD), = 40% Sustained Decline in Estimated Glomerular Filtration Rate (eGFR), CV Death or Renal Death	ESKD is defined as the following individual components: persistent eGFR <15 mL/min/1.73 m^2 confirmed by a second measurement at the earliest 4 weeks after the initial measurement at the central laboratory, initiation of dialysis for at least 30 days, receiving a kidney transplant.; Sustained decline in eGFR (=40%) will be confirmed by a repeated measure 1 month after the initial result.	Randomization up to Study Completion (Approximate 248 Weeks)
Secondary	Time to First Occurrence of Composite Endpoint of Major Cardiovascular Events (MACE-3)	MACE-3 includes CV death, nonfatal MI, and nonfatal stroke.	Randomization up to Study Completion (Approximate 248 Weeks)
Secondary	Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF	Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF.	Randomization up to Study Completion (Approximate 248 Weeks)
Secondary	Time to Occurrence of All-Cause Death	Time to all-cause death.	Randomization up to Study Completion (Approximate 248 Weeks)
Secondary	Time to First Occurrence of composite endpoint of = 40% Sustained Decline in eGFR, End-Stage Renal Disease (ESRD), or Renal Death		Randomization up to Study Completion (Approximate 248 Weeks)
Secondary	Percentage change from Baseline in Albuminuria urinary albumin/creatinine ratio (UACR) in Participants with UACR =30 mg/g (0.03 mg/mg) at baseline		Randomization up to Study Completion (Approximate 248 Weeks)

External Links

•   The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)