COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.

Status Active, not recruiting

Clinical Trial Summary

This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy and in combination with nivolumab.

Clinical Trial Description

This Phase 1 study evaluates the safety, tolerability, Pharmacokinetics (PK) and preliminary clinical activity of COM701 an inhibitor of poliovirus receptor related immunoglobulin domain containing (PVRIG) as monotherapy and in combination with nivolumab in subjects with advanced solid tumors. Cohort expansion will be explored evaluating COM701 monotherapy and in combination with nivolumab in subjects with the following select tumor types (Non-Small cell lung cancer (NSCLC), Ovarian, Breast (including Triple negative breast cancer (TNBC) and endometrial cancer. Other tumor types such as CRC-MSS, CRC-KRAS mutant will be enrolled based on emerging clinical activity data. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03667716
Study type	Interventional
Source	Compugen Ltd
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	September 6, 2018
Completion date	May 31, 2024

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