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Breast Neoplasms clinical trials

View clinical trials related to Breast Neoplasms.

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NCT ID: NCT05206656 Recruiting - Clinical trials for Metastatic Breast Cancer

Safety and Efficacy of Eribullin or Eribulin Combined With Anlotinib in Metastatic Breast Cancer

Start date: October 9, 2020
Phase: Phase 2
Study type: Interventional

Eribulin is the promising agent for late-line metastatic breast cancer patients. The aim of this Phase II, double-arm, open-label and prospective clinical trial is to assess the efficacy and safety of Eribullin or Eribulin combined with Anlotinib in patients with metastatic breast cancer

NCT ID: NCT05206526 Completed - Breast Cancer Clinical Trials

Dragonboat Activity for Breast Cancer

Start date: May 15, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to determine how a structured and supervised physical activity program linked to Dragon Boat practice can improve motivation to participate in physical activity sessions. It is also the purpose of this study to evaluate the improvement in body composition, body image perception and physical function. For this purpose, a group of women operated on for breast cancer was recruited and divided into two experimental groups: one group participated in a structured program of Dragon Boat while the other followed a home-based program of exercises independently in the home environment. Anthropometric measures (weight, height, BMI) and arm circumference, data on lifestyle and psychological well-being were evaluated by means of questionnaires. Tests were also performed to assess shoulder strength, aerobic capacity and mobility. The results of this study will (a) identify the strategies used that make Dragon Boat activity effective in ensuring quality participation in physical activity, (b) define the physiological effects of Dragon Boat activity on physical functionality and (c) correlating objective measures with subjective perceptions thanks to the integration of new body composition analysis techniques (regional BIA) and validated questionnaires on the perception of body image.

NCT ID: NCT05206396 Not yet recruiting - Breast Cancer Clinical Trials

TIL Relation to pCR After Neoadjuvant Therapy in Breast Cancer Patients

Start date: March 2022
Phase:
Study type: Observational

Neoadjuvant systemic treatment for breast cancer (used in locally advanced and operable breast cancer) includes anthracycline based chemotherapy (Doxorubicin/Cyclophosphamide) followed by taxanes (weekly Paclitaxel or Docetaxel) with antiHer-2 Trastuzumab or dual antiHer-2 Trastuzumab plus Pertuzumab. Other regimens include Docetaxel plus Carboplatin plus Trastuzumab alone or combined with pertuzumab for Her-2 positive patients. The tumor microenvironment, which includes extracellular matrix and stromal cells, is a key factor in tumorigenicity and the prediction of the efficacy of immunotherapy, conventional chemotherapy, and other anticancer therapies. Tumor-infiltrating lymphocytes (TILs), one of the most important components of the tumor microenvironment, were reported to predict the response to NAC both for tumors and axillary lymph nodes in breast cancer patients. This study is conducted to examine the relationship between tumor-infiltrating lymphocytes (categorized into three levels) and the pathologic complete response to neoadjuvant systemic therapy in breast cancer patients, and to examine the relationship between TILs and 1-year invasive disease-free survival (IDFS).

NCT ID: NCT05205200 Not yet recruiting - Breast Cancer Clinical Trials

Immune Therapy in HR-positive/HER2-negative Metastatic Breast Cancer(ENIGMA)

Start date: February 1, 2022
Phase: Phase 2
Study type: Interventional

This study is a prospective, open-label, phase II clinical study for patients with HR+/HER2- advanced breast cancer.

NCT ID: NCT05203497 Enrolling by invitation - Clinical trials for Breast Cancer Female

Molecular Imaging of HER2 Expression in Breast Cancer Using 99mTc-ZHER2.

Start date: December 22, 2021
Phase: Phase 1
Study type: Interventional

The study should evaluate distribution of 99mTc-ZHER2:41071 Affibody molecule in patients with primary HER2-positive and HER2-negative breast cancer The primary objectives are: 1. To assess distribution of 99mTc-ZHER2:41071 in normal tissues and in tumors over time; 2. To evaluate dosimetry of 99mTc-ZHER2:41071; 3. To obtain initial information concerning safety and tolerability of 99mTc-ZHER2:41071 after single intravenous injection: The secondary objectives are: 1. To compare the tumor imaging data with the data concerning HER2 expression obtained by immunohistochemistry (IHC) and/or fluorescent in situ hybridization (FISH) analysis of biopsy samples.

NCT ID: NCT05203458 Not yet recruiting - Breast Cancer, HER2 Clinical Trials

Prevalence and Clinicopathologic Features of Different HER2 Level in Chinese Breast Cancer Patients

HER2 PATH
Start date: January 31, 2022
Phase:
Study type: Observational

This retrospective study aims to describe the prevalence and clinical manifestations of different HER2 level BC by accurate reassessing of HER2 expression in archived HER2 IHC slides, and analysing clinicopathologic feature and outcomes from Fudan University Shanghai Cancer Centre (FUSCC) Breast Cancer Single Disease Database.

NCT ID: NCT05203445 Not yet recruiting - Breast Cancer Clinical Trials

A Study of Olaparib and Pembrolizumab in People With Triple Negative Breast Cancer (TNBC) or Hormone Receptor-positive HER2-negative Breast Cancer

Start date: January 14, 2022
Phase: Phase 2
Study type: Interventional

This study will test any good and bad effects of combining the study drugs pembrolizumab and olaparib, given before the standard surgical procedure, to treat TNBC or HR+ HER2- breast cancers. The study drugs could shrink cancer, but they could also cause side effects. The study researchers want to find out whether the study drugs will shrink the cancer by a certain percentage compared with its current size, which may improve the outcome of surgery.

NCT ID: NCT05203029 Recruiting - Clinical trials for Breast Cancer Survivors

Effectiveness of Aerobic Exercises and Laughter Yoga Compared With Yoga in Anxiety/Depression Levels in Breast Cancer

Start date: January 5, 2022
Phase: N/A
Study type: Interventional

90% of breast cancer survivors experience cancer-related fatigue which decreases the physical activity. Moreover, due to the cancer treatments depression and anxiety will be happened. Previous studies showed the effect of physical activity on reduction of depression and anxiety; therefore the aim of this study is to evaluate the effectiveness of aerobic exercises and laughter yoga compared with yoga in anxiety and depression levels in breast cancer survivors.

NCT ID: NCT05200078 Recruiting - Breast Cancer Clinical Trials

Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer

Start date: September 1, 2021
Phase:
Study type: Observational

Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.

NCT ID: NCT05198843 Not yet recruiting - Clinical trials for Anatomic Stage IV Breast Cancer AJCC v8

Testing an Omega-3 Fatty Acid-Based Anti-Cancer Therapy for Patients With Inflammatory Breast Cancer That Has Spread to Other Parts of the Body

Start date: March 25, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This phase Ib/II tests the safety, side effects, and best dose of icosapent ethyl in combination with dasatinib and whether they work in treating patients with triple-negative inflammatory breast cancer that has spread to other places in the body (metastatic). Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Icosapent ethyl is a highly purified omega-3 fatty acid that may slow tumor growth and disease progression. Giving dasatinib and icosapent ethyl may help shrink tumors in patients with inflammatory breast cancer.