Other Clinical Trial - Prone Positioning in COVID-19 Patients

Status Recruiting

Clinical Trial Summary

Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3). The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6). Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7). Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the recruitability position of the lung.in COVID-ARDS.

Clinical Trial Description

Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3). Prone ventilationARDS based on a randomized trial that showed a mortality benefit (PROSEVA) (3). The improvement of oxygenation occurs by making ventilation more homogeneous, limiting ventilator-associated lung injury (4-6). Prone positioning was as effective in improving oxygenation, static respiratory system compliance (Crs) (7).Higher PEEP should be applied when there is a high recruitability potential of the lung. This study aimed to investigate whether prone positioning changes the oxygenation, respiratory mechanics and recruitability position of the lung in COVID-ARDS. ;

Study Design

Related Conditions & MeSH terms

ARDS
Coronavirus Disease 2019
COVID-19
Mechanical Ventilation Pressure High

Clinical Trial Details

NCT number	NCT05150847
Study type	Interventional
Source	Tepecik Training and Research Hospital
Contact	KAZIM ROLLAS
Phone	+905532787535
Email	kazim.rollas@yahoo.com
Status	Recruiting
Phase	N/A
Start date	December 25, 2021
Completion date	April 13, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04435613` - Clinical and Physiological Assessment of a Nearly Ultra-protective Lung Ventilation Strategy: A Quasi-experimental Preliminary Study in ARDS Patients	N/A
Enrolling by invitation	`NCT05020210` - Effect of Early Treatment With Sivelestat Sodium in ARDS Patients
Completed	`NCT04468971` - REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia	Phase 1
Completed	`NCT04505592` - Tenecteplase in Patients With COVID-19	Phase 2
Completed	`NCT04493242` - Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS	Phase 2
Withdrawn	`NCT04909879` - Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Non-COVID-19 Acute Respiratory Distress Syndrome	Phase 2
Completed	`NCT02265198` - Relationship of Pulmonary Contusion to Pulmonary Inflammation and Incidence of Acute Respiratory Distress Syndrome	N/A
Completed	`NCT01949272` - Optimization of PEEP for Alveolar Recruitment in ARDS	N/A
Not yet recruiting	`NCT01668368` - Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance	N/A
Completed	`NCT01881061` - Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit	N/A
Completed	`NCT00808691` - Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit	N/A
Completed	`NCT05035589` - The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumonia
Recruiting	`NCT04764032` - Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Completed	`NCT04556513` - Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status
Recruiting	`NCT06036056` - NMR Based Metabolomics Kinetics in ARDS Patients
Recruiting	`NCT04503876` - Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome	N/A
Recruiting	`NCT04643691` - Losartan and Spironolactone Treatment for ICU Patients With COVID-19 Suffering From ARDS	Phase 2
Completed	`NCT04395911` - Safety and Efficacy of SCD in AKI or ARDS Patients Associated With COVID-19 Infections	N/A
Not yet recruiting	`NCT05341687` - Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.
Recruiting	`NCT05056090` - Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.	N/A