Clinical Trials Logo

Clinical Trial Summary

This study aims to establish whether tocilizumab has any significant effect on procalcitonin levels on patients diagnosed with COVID-19 pneumonia requiring intensive care admission. The effects on other biochemical and clinical markers are also considered.


Clinical Trial Description

A retrospective study, involving the first fifty patients treated with tocilizumab for acute deterioration in COVID-19 pneumonia in the Intensive Care Unit (ICU) at Mater Dei Hospital in Malta. The following parameters will be collected from medical records: - procalcitonin levels, daily for twenty days or until discharge or death. - namely white cell count (WCC), neutrophils, lymphocytes, - C-reactive protein (CRP) - PaO2/FiO2 ratio (P/F ratio). This group will be compared to a control group was chosen from patients admitted to the ICU who were not eligible for tocilizumab treatment, matched to the study group for age, gender, mode of ventilation required and length of stay in ICU. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05035589
Study type Observational
Source Sciberras, Stephen M.D.
Contact
Status Not yet recruiting
Phase
Start date September 20, 2021
Completion date November 20, 2021

See also
  Status Clinical Trial Phase
Completed NCT04435613 - Clinical and Physiological Assessment of a Nearly Ultra-protective Ventilation Strategy N/A
Active, not recruiting NCT04468971 - REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia Phase 1
Enrolling by invitation NCT04505592 - Tenecteplase in Patients With COVID-19 Phase 2
Completed NCT04493242 - Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS Phase 2
Not yet recruiting NCT04377334 - Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS) Phase 2
Withdrawn NCT04909879 - Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Non-COVID-19 Acute Respiratory Distress Syndrome Phase 2
Completed NCT02265198 - Relationship of Pulmonary Contusion to Pulmonary Inflammation and Incidence of Acute Respiratory Distress Syndrome N/A
Completed NCT01949272 - Optimization of PEEP for Alveolar Recruitment in ARDS N/A
Not yet recruiting NCT01668368 - Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance N/A
Completed NCT01881061 - Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit N/A
Completed NCT00808691 - Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit N/A
Not yet recruiting NCT04973670 - Protective Effect of Sivelestat Sodium on ARDS in Patients With Sepsis Complicated With Respiratory Failure Phase 3
Recruiting NCT04764032 - Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Recruiting NCT04556513 - Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Economic Status
Recruiting NCT04503876 - Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome N/A
Recruiting NCT04643691 - Losartan and Spironolactone Treatment for ICU Patients With COVID-19 Suffering From ARDS Phase 2
Completed NCT04395911 - Safety and Efficacy of SCD in AKI or ARDS Patients Associated With COVID-19 Infections N/A
Recruiting NCT05056090 - Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome. A Multicenter Randomized Controlled Trial N/A
Not yet recruiting NCT05023226 - Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS N/A
Recruiting NCT04694742 - Ventilatory Efficiency in Critically Ill COVID-19 Patients