Clinical Trials Logo

Clinical Trial Summary

Among patients with ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD). Myocardial infarction (MI) with non-obstructive coronary artery disease (MINOCA) accounts for 5-20% of patients with MI and preferentially affects women. MINOCA pathogenesis is varied and may include atherosclerotic plaque rupture, plaque erosion with thrombosis, vasospasm, embolization, dissection or a combination of mechanisms. Other patients may have clinically unrecognized myocarditis, or takotsubo syndrome masquerading as MI. Among patients referred for coronary angiography for the evaluation of stable ischemic heart disease, non-obstructive CAD is present in up to ~30% of men and ~60% of women. Stable ischemia with non-obstructive coronary arteries (INOCA) may be due to coronary microvascular dysfunction in up to 40% of these patients. Our understanding of mechanisms of MINOCA and INOCA remain incomplete. Coronary inflammation has been hypothesized as a potential mechanism contributing to coronary spasm in MINOCA and microvascular disease in INOCA.


Clinical Trial Description

The PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease (POINT-NOCAD) study is a single-center diagnostic, observational study enrolling men and women with MINOCA or INOCA who are planned to undergo (or underwent) clinically indicated coronary angiography. The research plan is to evaluate coronary inflammation, as measured by the perivascular coronary fat attenuation index from non-invasive coronary computed tomography angiography (CCTA), in patients with MINOCA and INOCA. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05031520
Study type Interventional
Source NYU Langone Health
Contact Nathaniel Smilowitz, MD
Phone 212-263-5656
Email [email protected]
Status Recruiting
Phase N/A
Start date July 12, 2021
Completion date December 2024

See also
  Status Clinical Trial Phase
Recruiting NCT04827498 - Myocardial Ischemia Without Obstructive Coronary Stenoses
Enrolling by invitation NCT03982901 - Effect of Mental Stress on Myocardial Perfusion in Women N/A
Recruiting NCT05035056 - WARRIOR Ancillary Study for CCTA Analysis N/A
Recruiting NCT04186676 - Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population
Recruiting NCT04805814 - Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial N/A
Recruiting NCT04674449 - iCorMicA - Stratified Medicine in Angina N/A