Anatomic Stage III Breast Cancer AJCC v8 Clinical Trial
Official title:
Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions
This phase III trial compares an additional support program (text message reminders and/or telephone-based counseling) with usual care in making sure breast cancer patients take their endocrine therapy medication as prescribed (medication adherence). Medication adherence is how well patients take the medication as prescribed by their doctors, and good medical adherence is when patients take medications correctly. Poor medication adherence has been shown to be a serious barrier to effective treatment for hormone receptor positive breast cancer patients. Adding text message reminders and/or telephone-based counseling to usual care may increase the number of days that patients take their endocrine therapy medication as prescribed.
Status | Recruiting |
Enrollment | 1180 |
Est. completion date | October 2025 |
Est. primary completion date | October 2025 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility | - Women with an initial pathologically confirmed diagnosis of stage I-III, hormone receptor positive, HER2-neu negative, invasive breast cancer within 18 months prior to enrollment - Women who have undergone neo-adjuvant chemotherapy who have no residual invasive disease post-surgery are eligible based on an initial pathologically confirmed diagnosis - Hormone receptor positive is defined as estrogen receptor (ER) and/or progesterone receptor (PR) of > 1% - HER2-neu negative is defined as 0-1+ by immunohistochemical (IHC) analysis, or non-amplified by fluorescence in situ hybridization (FISH) analysis - Patients must have received cancer-directed surgery, and/or completed all other adjuvant therapy, except reconstruction - Patients must have initiated an endocrine therapy drug within the 6 months prior to registration, OR have received a prescription with stated intent to initiate within 6 weeks after registration - No history of previous cancer as follows: - Invasive or non-invasive breast cancer at any time - Non-breast cancer, within the past 5 years, excluding non-melanoma skin cancer - Patients must be willing to use a smart phone for study activities - Patient is NOT to be deemed ineligible during the recruitment process if they do not have a smart phone - If a participant does not own a smart phone or has limited data or texting capabilities or their smart phone cannot support the Alliance electronic patient reported outcomes (ePRO) survey application (app), a smart phone and service can be provided to the participant at no cost through the Ohio State University (OSU) partnership with Verizon Wireless for the duration of the study activities - The CRP is ONLY to discuss this option with those patients who self-identify a phone-related barrier to participation, including: lack of a smart phone, insufficient phone plan (minutes/text/data), or a smart phone incompatible with the Alliance ePRO app - For OSU -provided phones, charges will be paid by the grant through the intervention period. At the end of the 12-month intervention period, patients will be responsible for paying monthly fees, if continued service is desired. The physical phones will belong to the patients at the end of their study activities - Patients must be willing to use a Pillsy medication event monitoring system for the duration of study participation - In order to complete the mandatory patient-completed measures, participants must be able to speak and read English |
Country | Name | City | State |
---|---|---|---|
United States | Hawaii Cancer Care - Westridge | 'Aiea | Hawaii |
United States | Summa Health System - Akron Campus | Akron | Ohio |
United States | Phoebe Putney Memorial Hospital | Albany | Georgia |
United States | Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota |
United States | Presbyterian Kaseman Hospital | Albuquerque | New Mexico |
United States | Aultman Alliance Community Hospital | Alliance | Ohio |
United States | Mary Greeley Medical Center | Ames | Iowa |
United States | McFarland Clinic - Ames | Ames | Iowa |
United States | Community Hospital of Anaconda | Anaconda | Montana |
United States | Kaiser Permanente-Anaheim | Anaheim | California |
United States | AnMed Health Cancer Center | Anderson | South Carolina |
United States | UTMB Health Angleton Danbury Campus | Angleton | Texas |
United States | Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan |
United States | Luminis Health Anne Arundel Medical Center | Annapolis | Maryland |
United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
United States | Ascension Saint Elizabeth Hospital | Appleton | Wisconsin |
United States | Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California |
United States | AdventHealth Infusion Center Asheville | Asheville | North Carolina |
United States | Duluth Clinic Ashland | Ashland | Wisconsin |
United States | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York |
United States | MultiCare Auburn Medical Center | Auburn | Washington |
United States | Sutter Auburn Faith Hospital | Auburn | California |
United States | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado |
United States | Rush - Copley Medical Center | Aurora | Illinois |
United States | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon |
United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
United States | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri |
United States | Mercy Medical Center | Baltimore | Maryland |
United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
United States | Summa Health System - Barberton Campus | Barberton | Ohio |
United States | Advocate Good Shepherd Hospital | Barrington | Illinois |
United States | Bronson Battle Creek | Battle Creek | Michigan |
United States | Baptist Hospitals of Southeast Texas Cancer Center | Beaumont | Texas |
United States | Indu and Raj Soin Medical Center | Beavercreek | Ohio |
United States | UM Upper Chesapeake Medical Center | Bel Air | Maryland |
United States | Kaiser Permanente-Bellflower | Bellflower | California |
United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
United States | Saint Charles Health System | Bend | Oregon |
United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
United States | UCSF Cancer Center - Berkeley | Berkeley | California |
United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
United States | Beverly Hospital | Beverly | Massachusetts |
United States | Billings Clinic Cancer Center | Billings | Montana |
United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
United States | Saint Elizabeth Boardman Hospital | Boardman | Ohio |
United States | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina |
United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
United States | McFarland Clinic - Boone | Boone | Iowa |
United States | Dana-Farber Cancer Institute | Boston | Massachusetts |
United States | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado |
United States | Bozeman Health Deaconess Hospital | Bozeman | Montana |
United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
United States | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan |
United States | Trinity Health Medical Center - Brighton | Brighton | Michigan |
United States | Bristol Regional Medical Center | Bristol | Tennessee |
United States | Wellmont Medical Associates-Bristol | Bristol | Virginia |
United States | Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin |
United States | Maimonides Medical Center | Brooklyn | New York |
United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
United States | Fairview Ridges Hospital | Burnsville | Minnesota |
United States | Minnesota Oncology - Burnsville | Burnsville | Minnesota |
United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
United States | Cambridge Medical Center | Cambridge | Minnesota |
United States | Aultman Health Foundation | Canton | Ohio |
United States | Illinois CancerCare-Canton | Canton | Illinois |
United States | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan |
United States | Trinity Health Medical Center - Canton | Canton | Michigan |
United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
United States | Southeast Cancer Center | Cape Girardeau | Missouri |
United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
United States | SIH Cancer Institute | Carterville | Illinois |
United States | Illinois CancerCare-Carthage | Carthage | Illinois |
United States | Waverly Hematology Oncology | Cary | North Carolina |
United States | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa |
United States | Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa |
United States | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado |
United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
United States | Miami Valley Hospital South | Centerville | Ohio |
United States | Centralia Oncology Clinic | Centralia | Illinois |
United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
United States | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina |
United States | Saint Joseph Mercy Chelsea | Chelsea | Michigan |
United States | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan |
United States | Cancer Specialists of Tidewater Limited | Chesapeake | Virginia |
United States | Advocate Illinois Masonic Medical Center | Chicago | Illinois |
United States | Adventist Health Cancer Care Center Chico | Chico | California |
United States | Enloe Medical Center | Chico | California |
United States | Ascension Calumet Hospital | Chilton | Wisconsin |
United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
United States | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio |
United States | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon |
United States | Newland Medical Associates-Clarkston | Clarkston | Michigan |
United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
United States | AdventHealth Infusion Center Haywood | Clyde | North Carolina |
United States | Billings Clinic-Cody | Cody | Wyoming |
United States | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho |
United States | Main Line Health Center-Collegeville | Collegeville | Pennsylvania |
United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
United States | MU Health - University Hospital/Ellis Fischel Cancer Center | Columbia | Missouri |
United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
United States | The Mark H Zangmeister Center | Columbus | Ohio |
United States | Cookeville Regional Medical Center | Cookeville | Tennessee |
United States | Mercy Hospital | Coon Rapids | Minnesota |
United States | AMG Crystal Lake - Oncology | Crystal Lake | Illinois |
United States | Danbury Hospital | Danbury | Connecticut |
United States | Carle at The Riverfront | Danville | Illinois |
United States | Genesis Cancer Care Institute | Davenport | Iowa |
United States | Genesis Medical Center - East Campus | Davenport | Iowa |
United States | Iowa Cancer Specialists | Davenport | Iowa |
United States | Dayton Physician LLC - Englewood | Dayton | Ohio |
United States | Miami Valley Hospital | Dayton | Ohio |
United States | Miami Valley Hospital North | Dayton | Ohio |
United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
United States | Decatur Memorial Hospital | Decatur | Illinois |
United States | Essentia Health - Deer River Clinic | Deer River | Minnesota |
United States | Broward Health North | Deerfield Beach | Florida |
United States | Kaiser Permanente-Franklin | Denver | Colorado |
United States | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado |
United States | Rocky Mountain Cancer Centers-Rose | Denver | Colorado |
United States | Broadlawns Medical Center | Des Moines | Iowa |
United States | Iowa Lutheran Hospital | Des Moines | Iowa |
United States | Iowa Methodist Medical Center | Des Moines | Iowa |
United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
United States | Mission Cancer and Blood - Des Moines | Des Moines | Iowa |
United States | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota |
United States | Illinois CancerCare-Dixon | Dixon | Illinois |
United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
United States | Advocate Good Samaritan Hospital | Downers Grove | Illinois |
United States | Columbus Oncology and Hematology Associates | Dublin | Ohio |
United States | Kaiser Permanente Dublin | Dublin | California |
United States | Essentia Health Cancer Center | Duluth | Minnesota |
United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
United States | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York |
United States | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin |
United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
United States | Fairview Southdale Hospital | Edina | Minnesota |
United States | Carle Physician Group-Effingham | Effingham | Illinois |
United States | Crossroads Cancer Center | Effingham | Illinois |
United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
United States | Advocate Sherman Hospital | Elgin | Illinois |
United States | Walter Knox Memorial Hospital | Emmett | Idaho |
United States | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado |
United States | Rocky Mountain Cancer Centers - Swedish | Englewood | Colorado |
United States | Illinois CancerCare-Eureka | Eureka | Illinois |
United States | Main Line Health Center-Exton | Exton | Pennsylvania |
United States | Fairbanks Memorial Hospital | Fairbanks | Alaska |
United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
United States | Sanford Broadway Medical Center | Fargo | North Dakota |
United States | Sanford Medical Center Fargo | Fargo | North Dakota |
United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
United States | Sanford South University Medical Center | Fargo | North Dakota |
United States | Southpointe-Sanford Medical Center Fargo | Fargo | North Dakota |
United States | Parkland Health Center - Farmington | Farmington | Missouri |
United States | Armes Family Cancer Center | Findlay | Ohio |
United States | Blanchard Valley Hospital | Findlay | Ohio |
United States | Orion Cancer Care | Findlay | Ohio |
United States | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia |
United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
United States | Genesee Hematology Oncology PC | Flint | Michigan |
United States | Genesys Hurley Cancer Institute | Flint | Michigan |
United States | Kaiser Permanente-Fontana | Fontana | California |
United States | McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa |
United States | Trinity Regional Medical Center | Fort Dodge | Iowa |
United States | Broward Health Medical Center | Fort Lauderdale | Florida |
United States | Mercy Hospital Fort Smith | Fort Smith | Arkansas |
United States | Essentia Health - Fosston | Fosston | Minnesota |
United States | Beebe South Coastal Health Campus | Frankford | Delaware |
United States | Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin |
United States | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio |
United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
United States | CentraState Medical Center | Freehold | New Jersey |
United States | Kaiser Permanente-Fremont | Fremont | California |
United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
United States | Kaiser Permanente-Fresno | Fresno | California |
United States | Unity Hospital | Fridley | Minnesota |
United States | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina |
United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
United States | University of Texas Medical Branch | Galveston | Texas |
United States | CaroMont Regional Medical Center | Gastonia | North Carolina |
United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
United States | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington |
United States | Arizona Center for Cancer Care - Gilbert | Gilbert | Arizona |
United States | UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland |
United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
United States | Peninsula Cancer Institute-Gloucester | Gloucester | Virginia |
United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
United States | Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan |
United States | Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan |
United States | Benefis Sletten Cancer Institute | Great Falls | Montana |
United States | Great Falls Clinic | Great Falls | Montana |
United States | Banner North Colorado Medical Center | Greeley | Colorado |
United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
United States | Dayton Physicians LLC-Wayne | Greenville | Ohio |
United States | East Carolina University | Greenville | North Carolina |
United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
United States | Wayne Hospital | Greenville | Ohio |
United States | Gibbs Cancer Center-Pelham | Greer | South Carolina |
United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
United States | Kaiser Permanente - Harbor City | Harbor City | California |
United States | Ingalls Memorial Hospital | Harvey | Illinois |
United States | Advocate South Suburban Hospital | Hazel Crest | Illinois |
United States | OptumCare Cancer Care at Seven Hills | Henderson | Nevada |
United States | AdventHealth Hendersonville | Hendersonville | North Carolina |
United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
United States | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii |
United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
United States | Queen's Medical Center | Honolulu | Hawaii |
United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
United States | Cancer Center of Kansas-Independence | Independence | Kansas |
United States | Kaiser Permanente-Irvine | Irvine | California |
United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
United States | Essentia Health - Jamestown Clinic | Jamestown | North Dakota |
United States | McFarland Clinic - Jefferson | Jefferson | Iowa |
United States | MU Health Care Goldschmidt Cancer Center | Jefferson City | Missouri |
United States | Freeman Health System | Joplin | Missouri |
United States | Mercy Hospital Joplin | Joplin | Missouri |
United States | Ascension Borgess Cancer Center | Kalamazoo | Michigan |
United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
United States | West Michigan Cancer Center | Kalamazoo | Michigan |
United States | Kalispell Regional Medical Center | Kalispell | Montana |
United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
United States | Greater Dayton Cancer Center | Kettering | Ohio |
United States | Kettering Medical Center | Kettering | Ohio |
United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
United States | Cancer Center of Kansas-Kingman | Kingman | Kansas |
United States | Ballad Health Cancer Care - Kingsport | Kingsport | Tennessee |
United States | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee |
United States | Marshfield Medical Center - Ladysmith | Ladysmith | Wisconsin |
United States | Kaiser Permanente-Rock Creek | Lafayette | Colorado |
United States | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado |
United States | Doctor's Hospital of Laredo | Laredo | Texas |
United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
United States | Hope Cancer Care of Nevada | Las Vegas | Nevada |
United States | OptumCare Cancer Care at Charleston | Las Vegas | Nevada |
United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
United States | OptumCare Cancer Care at MountainView | Las Vegas | Nevada |
United States | UTMB Cancer Center at Victory Lakes | League City | Texas |
United States | Saint Joseph Hospital East | Lexington | Kentucky |
United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
United States | AMG Libertyville - Oncology | Libertyville | Illinois |
United States | Condell Memorial Hospital | Libertyville | Illinois |
United States | CaroMont Health - Lincoln Cancer Center | Lincolnton | North Carolina |
United States | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado |
United States | Hope Cancer Clinic | Livonia | Michigan |
United States | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan |
United States | Kaiser Permanente-Lone Tree | Lone Tree | Colorado |
United States | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado |
United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
United States | Kaiser Permanente West Los Angeles | Los Angeles | California |
United States | Banner McKee Medical Center | Loveland | Colorado |
United States | Illinois CancerCare-Macomb | Macomb | Illinois |
United States | University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin |
United States | Cancer Center of Kansas-Manhattan | Manhattan | Kansas |
United States | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota |
United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
United States | McFarland Clinic - Marshalltown | Marshalltown | Iowa |
United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
United States | Fremont - Rideout Cancer Center | Marysville | California |
United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
United States | Redeemer Health | Meadowbrook | Pennsylvania |
United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
United States | Aspirus Medford Hospital | Medford | Wisconsin |
United States | Riddle Memorial Hospital | Media | Pennsylvania |
United States | Summa Health Medina Medical Center | Medina | Ohio |
United States | Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin |
United States | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin |
United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
United States | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin |
United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
United States | Health Partners Inc | Minneapolis | Minnesota |
United States | Hennepin County Medical Center | Minneapolis | Minnesota |
United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
United States | Community Medical Center | Missoula | Montana |
United States | Kaiser Permanente-Modesto | Modesto | California |
United States | Trinity Medical Center | Moline | Illinois |
United States | Monticello Cancer Center | Monticello | Minnesota |
United States | Virtua Samson Cancer Center | Moorestown | New Jersey |
United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
United States | Knox Community Hospital | Mount Vernon | Ohio |
United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
United States | Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho |
United States | CarolinaEast Medical Center | New Bern | North Carolina |
United States | Saint Peter's University Hospital | New Brunswick | New Jersey |
United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
United States | New Ulm Medical Center | New Ulm | Minnesota |
United States | Helen F Graham Cancer Center | Newark | Delaware |
United States | Licking Memorial Hospital | Newark | Ohio |
United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
United States | Providence Newberg Medical Center | Newberg | Oregon |
United States | Peninsula Cancer Institute-Newport News | Newport News | Virginia |
United States | Cancer Center of Kansas - Newton | Newton | Kansas |
United States | Bon Secours DePaul Medical Center | Norfolk | Virginia |
United States | Southwest VA Regional Cancer Center | Norton | Virginia |
United States | Norwalk Hospital | Norwalk | Connecticut |
United States | Ascension Providence Hospitals - Novi | Novi | Michigan |
United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
United States | Drexel Town Square Health Center | Oak Creek | Wisconsin |
United States | Advocate Christ Medical Center | Oak Lawn | Illinois |
United States | Kaiser Permanente-Oakland | Oakland | California |
United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
United States | Kaiser Permanente-Ontario | Ontario | California |
United States | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon |
United States | Ascension Mercy Hospital | Oshkosh | Wisconsin |
United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
United States | Kaiser Permanente - Panorama City | Panorama City | California |
United States | Paoli Memorial Hospital | Paoli | Pennsylvania |
United States | Essentia Health - Park Rapids | Park Rapids | Minnesota |
United States | Advocate Lutheran General Hospital | Park Ridge | Illinois |
United States | Cancer Center of Kansas - Parsons | Parsons | Kansas |
United States | Lahey Medical Center-Peabody | Peabody | Massachusetts |
United States | Illinois CancerCare-Pekin | Pekin | Illinois |
United States | Arizona Center for Cancer Care-Peoria | Peoria | Arizona |
United States | Illinois CancerCare-Peoria | Peoria | Illinois |
United States | Methodist Medical Center of Illinois | Peoria | Illinois |
United States | Illinois CancerCare-Peru | Peru | Illinois |
United States | Valley Radiation Oncology | Peru | Illinois |
United States | Arizona Center for Cancer Care - Phoenix | Phoenix | Arizona |
United States | Cancer Center at Saint Joseph's | Phoenix | Arizona |
United States | Phoenixville Hospital | Phoenixville | Pennsylvania |
United States | Penn Medicine Princeton Health | Plainsboro | New Jersey |
United States | Newland Medical Associates-Pontiac | Pontiac | Michigan |
United States | Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan |
United States | Jefferson Healthcare | Port Townsend | Washington |
United States | Providence Portland Medical Center | Portland | Oregon |
United States | Providence Saint Vincent Medical Center | Portland | Oregon |
United States | Bon Secours Maryview Medical Center | Portsmouth | Virginia |
United States | Southern Ohio Medical Center | Portsmouth | Ohio |
United States | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho |
United States | Pottstown Hospital | Pottstown | Pennsylvania |
United States | Vassar Brothers Medical Center | Poughkeepsie | New York |
United States | Cancer Center of Kansas - Pratt | Pratt | Kansas |
United States | Fairview Northland Medical Center | Princeton | Minnesota |
United States | Illinois CancerCare-Princeton | Princeton | Illinois |
United States | Rhode Island Hospital | Providence | Rhode Island |
United States | Women and Infants Hospital | Providence | Rhode Island |
United States | MultiCare Good Samaritan Hospital | Puyallup | Washington |
United States | Ascension All Saints Hospital | Racine | Wisconsin |
United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
United States | Northwest Hospital Center | Randallstown | Maryland |
United States | Corewell Health Reed City Hospital | Reed City | Michigan |
United States | Beebe Health Campus | Rehoboth Beach | Delaware |
United States | Saint Mary's Regional Medical Center | Reno | Nevada |
United States | Valley Medical Center | Renton | Washington |
United States | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin |
United States | Bon Secours Cancer Institute at Reynolds Crossing | Richmond | Virginia |
United States | Bon Secours Saint Mary's Hospital | Richmond | Virginia |
United States | Kaiser Permanente-Richmond | Richmond | California |
United States | Reid Health | Richmond | Indiana |
United States | VCU Massey Cancer Center at Stony Point | Richmond | Virginia |
United States | Virginia Cancer Institute | Richmond | Virginia |
United States | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia |
United States | Presbyterian Rust Medical Center/Jorgensen Cancer Center | Rio Rancho | New Mexico |
United States | West Suburban Medical Center | River Forest | Illinois |
United States | Kaiser Permanente-Riverside | Riverside | California |
United States | North Memorial Medical Health Center | Robbinsdale | Minnesota |
United States | Mayo Clinic in Rochester | Rochester | Minnesota |
United States | Memorial Hospital of Sweetwater County | Rock Springs | Wyoming |
United States | OSF Saint Anthony Medical Center | Rockford | Illinois |
United States | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri |
United States | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri |
United States | Kaiser Permanente-Roseville | Roseville | California |
United States | Sutter Roseville Medical Center | Roseville | California |
United States | Kaiser Permanente Downtown Commons | Sacramento | California |
United States | Kaiser Permanente-South Sacramento | Sacramento | California |
United States | Sutter Medical Center Sacramento | Sacramento | California |
United States | Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan |
United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
United States | Mercy Hospital South | Saint Louis | Missouri |
United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
United States | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri |
United States | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota |
United States | Regions Hospital | Saint Paul | Minnesota |
United States | United Hospital | Saint Paul | Minnesota |
United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
United States | Cancer Center of Kansas - Salina | Salina | Kansas |
United States | Kaiser Permanente-San Diego Zion | San Diego | California |
United States | Kaiser Permanente-San Francisco | San Francisco | California |
United States | Zuckerberg San Francisco General Hospital | San Francisco | California |
United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
United States | Kaiser Permanente San Leandro | San Leandro | California |
United States | Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California |
United States | Kaiser Permanente-San Marcos | San Marcos | California |
United States | UCSF Cancer Center - San Mateo | San Mateo | California |
United States | Kaiser San Rafael-Gallinas | San Rafael | California |
United States | Kootenai Cancer Clinic | Sandpoint | Idaho |
United States | Essentia Health Sandstone | Sandstone | Minnesota |
United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
United States | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California |
United States | Mission Hope Medical Oncology - Santa Maria | Santa Maria | California |
United States | Saint John's Cancer Institute | Santa Monica | California |
United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
United States | Memorial Health University Medical Center | Savannah | Georgia |
United States | Summit Cancer Care-Memorial | Savannah | Georgia |
United States | Arizona Center for Cancer Care - Osborn | Scottsdale | Arizona |
United States | Arizona Center for Cancer Care - Scottsdale | Scottsdale | Arizona |
United States | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina |
United States | Saint Francis Regional Medical Center | Shakopee | Minnesota |
United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
United States | Welch Cancer Center | Sheridan | Wyoming |
United States | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana |
United States | Genesis Cancer Center - Silvis | Silvis | Illinois |
United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
United States | Ascension Providence Hospitals - Southfield | Southfield | Michigan |
United States | Spartanburg Medical Center | Spartanburg | South Carolina |
United States | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington |
United States | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington |
United States | CoxHealth South Hospital | Springfield | Missouri |
United States | Memorial Medical Center | Springfield | Illinois |
United States | Mercy Hospital Springfield | Springfield | Missouri |
United States | Southern Illinois University School of Medicine | Springfield | Illinois |
United States | Springfield Clinic | Springfield | Illinois |
United States | Springfield Regional Cancer Center | Springfield | Ohio |
United States | Springfield Regional Medical Center | Springfield | Ohio |
United States | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin |
United States | Lakeview Hospital | Stillwater | Minnesota |
United States | Kaiser Permanente-Stockton | Stockton | California |
United States | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin |
United States | Bon Secours Health Center at Harbour View | Suffolk | Virginia |
United States | Cancer Specialists of Tidewater-Suffolk | Suffolk | Virginia |
United States | Missouri Baptist Sullivan Hospital | Sullivan | Missouri |
United States | Aurora Medical Center in Summit | Summit | Wisconsin |
United States | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California |
United States | BJC Outpatient Center at Sunset Hills | Sunset Hills | Missouri |
United States | Arizona Center for Cancer Care-Surprise | Surprise | Arizona |
United States | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York |
United States | State University of New York Upstate Medical University | Syracuse | New York |
United States | MultiCare Tacoma General Hospital | Tacoma | Washington |
United States | Tallahassee Memorial HealthCare | Tallahassee | Florida |
United States | Holy Name Hospital | Teaneck | New Jersey |
United States | Sanford Thief River Falls Medical Center | Thief River Falls | Minnesota |
United States | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas |
United States | UM Saint Joseph Medical Center | Towson | Maryland |
United States | Dayton Physicians LLC - Troy | Troy | Ohio |
United States | Upper Valley Medical Center | Troy | Ohio |
United States | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California |
United States | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin |
United States | MGC Hematology Oncology-Union | Union | South Carolina |
United States | Carle Cancer Center | Urbana | Illinois |
United States | The Carle Foundation Hospital | Urbana | Illinois |
United States | Kaiser Permanente Medical Center-Vacaville | Vacaville | California |
United States | Kaiser Permanente-Vallejo | Vallejo | California |
United States | Upstate Cancer Center at Verona | Verona | New York |
United States | Inspira Medical Center Vineland | Vineland | New Jersey |
United States | Essentia Health Virginia Clinic | Virginia | Minnesota |
United States | Peninsula Cancer Institute-Cancer Specialists of Tidewater | Virginia Beach | Virginia |
United States | Virtua Voorhees | Voorhees | New Jersey |
United States | Ridgeview Medical Center | Waconia | Minnesota |
United States | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington |
United States | Kaiser Permanente-Walnut Creek | Walnut Creek | California |
United States | Saint Joseph Warren Hospital | Warren | Ohio |
United States | Kent Hospital | Warwick | Rhode Island |
United States | Mercy Hospital Washington | Washington | Missouri |
United States | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin |
United States | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin |
United States | Aspirus Regional Cancer Center | Wausau | Wisconsin |
United States | Marshfield Clinic-Wausau Center | Wausau | Wisconsin |
United States | Ascension Medical Group Southeast Wisconsin - Mayfair Road | Wauwatosa | Wisconsin |
United States | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin |
United States | AdventHealth Infusion Center Weaverville | Weaverville | North Carolina |
United States | Cancer Center of Kansas - Wellington | Wellington | Kansas |
United States | Aurora West Allis Medical Center | West Allis | Wisconsin |
United States | Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin |
United States | Methodist West Hospital | West Des Moines | Iowa |
United States | Good Samaritan University Hospital | West Islip | New York |
United States | William E Kahlert Regional Cancer Center/Sinai Hospital | Westminster | Maryland |
United States | Marshfield Medical Center - Weston | Weston | Wisconsin |
United States | Ascension Via Christi Hospitals Wichita | Wichita | Kansas |
United States | Cancer Center of Kansas - Wichita | Wichita | Kansas |
United States | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas |
United States | Peninsula Cancer Institute-Williamsburg | Williamsburg | Virginia |
United States | Rice Memorial Hospital | Willmar | Minnesota |
United States | Winchester Hospital | Winchester | Massachusetts |
United States | Cancer Center of Kansas - Winfield | Winfield | Kansas |
United States | Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin |
United States | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin |
United States | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota |
United States | Kaiser Permanente-Woodland Hills | Woodland Hills | California |
United States | Sanford Cancer Center Worthington | Worthington | Minnesota |
United States | Lankenau Medical Center | Wynnewood | Pennsylvania |
United States | Fairview Lakes Medical Center | Wyoming | Minnesota |
United States | University of Michigan Health - West | Wyoming | Michigan |
United States | Rush-Copley Healthcare Center | Yorkville | Illinois |
United States | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio |
United States | Huron Gastroenterology PC | Ypsilanti | Michigan |
United States | Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan |
Lead Sponsor | Collaborator |
---|---|
Alliance for Clinical Trials in Oncology | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Endocrine therapy (ET) adherence at 12 months post-randomization | ET adherence at 12 months post-randomization will be measured by electronic pill monitoring cap (Pillsy-reported) and defined as the proportion of patients within each arm who have taken their ET medication for at least 292 of 365 days. | At 12 months post-randomization | |
Secondary | Endocrine therapy (ET) adherence at 24 months post-randomization | ET adherence at 24 months post-randomization will be measured by electronic pill monitoring cap (Pillsy-reported) and defined as the proportion of patients within each arm who have taken their ET medication for at least 584 of 730 days. | At 24 months post-randomization |
Status | Clinical Trial | Phase | |
---|---|---|---|
Suspended |
NCT05673200 -
Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer
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Phase 1 | |
Active, not recruiting |
NCT03218826 -
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
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Phase 1 | |
Completed |
NCT04535323 -
Platelet Rich Plasma for the Treatment of Genitourinary Syndrome of Menopause in Patients With Stage 0-III Breast Cancer
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Phase 1 | |
Recruiting |
NCT05464810 -
Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
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Early Phase 1 | |
Active, not recruiting |
NCT04249622 -
Rifaximin for the Treatment of Gastrointestinal Toxicities Related to Pertuzumab-Based Therapy in Patients With Stage I-III HER2 Positive Breast Cancer
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Phase 2 | |
Withdrawn |
NCT03666819 -
Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal Atrophy
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Phase 2 | |
Not yet recruiting |
NCT05930483 -
Remotely Delivered, Culturally Tailored Weight Loss Interventions Among Latina Breast Cancer Survivors
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N/A | |
Recruiting |
NCT04862585 -
Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel
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Phase 2/Phase 3 | |
Withdrawn |
NCT05967286 -
Olaparib and Alpelisib for Treatment of Metastatic Breast Cancer, A ComboMATCH Treatment Trial
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Phase 2 | |
Recruiting |
NCT04593277 -
Interactive Survivorship Program for the Improvement of Healthcare Resources in Adolescent and Young Adult Cancer Survivors, INSPIRE-AYA Study
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N/A | |
Active, not recruiting |
NCT05086731 -
Mobile Health to Improve Oral Chemotherapy Adherence Among Women With Breast Cancer
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N/A | |
Recruiting |
NCT05368428 -
Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer
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N/A | |
Recruiting |
NCT04673448 -
Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer
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Phase 1 | |
Not yet recruiting |
NCT05539365 -
Dendritic Cell-Based Treatment Plus Immunotherapy for the Treatment of Metastatic or Unresectable Triple Negative Breast Cancer
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Phase 2 | |
Active, not recruiting |
NCT04086875 -
A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer
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N/A | |
Completed |
NCT00507923 -
Tibetan Yoga in Improving Fatigue and Sleep in Participants With Stage I-III Breast Cancer
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N/A | |
Recruiting |
NCT06058377 -
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
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Phase 3 | |
Active, not recruiting |
NCT04514484 -
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV
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Phase 1 | |
Recruiting |
NCT05455658 -
STEMVAC in Patients With Early Stage Triple Negative Breast Cancer
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Phase 2 | |
Recruiting |
NCT05674578 -
Health Coaching-Based Navigation at the Conclusion of Treatment for the Support of Black Breast Cancer Survivors
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N/A |