STEMI - ST Elevation Myocardial Infarction Clinical Trial
— TregCMRRSOfficial title:
Combination With Regulatory T Cell Levels and Cardiac Magnetic Resonance Imaging (CMR) to Assess the Severity and Prognosis of Reperfusion Injury After Primary PCI in STEMI Patients (TregCMRRS)
This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in STEMI patients receiving primary percutaneous coronary intervention (PPCI).
Status | Recruiting |
Enrollment | 250 |
Est. completion date | August 31, 2021 |
Est. primary completion date | August 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Confirmed STEMI diagnosis - Undergoing primary percutaneous coronary intervention (presenting <12 hours after symptom onset) - Patients were able to complete cardiac magnetic resonance imaging (CMR) and speckle tracking imaging echocardiogram (STE) examinations - Patients agreed and provided informed consent Exclusion Criteria: - Previous myocardial infarction or revascularization (PCI or CABG) - Congestive heart failure with LVEF<40% - Atrial fibrillation - Renal insufficiency (GFR < 30 ml/min/1.73m^2) - Acute infectious diseases within nearly 3 months - Rheumatic immune system diseases - Malignant tumors - Claustrophobia - Contraindicated to CMR - Patients do not agree to be included in the study |
Country | Name | City | State |
---|---|---|---|
China | Beijing Friendship Hospital, Capital Medical University | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Beijing Friendship Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | MACE (major adverse cardiovascular events) | nonfatal or fatal myocardial infarction, revascularization, cardiac death, nonfatal or fatal stroke, all cause of death | 12 months | |
Secondary | adverse cardiac remodeling | a cut-off value of 12% change in left ventricular end-diastolic volume between the acute and follow-up magnetic resonance scans | 6 months |
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