Other Clinical Trial - Effect of PPCI on Diastolic Function & Levels of

Status Recruiting

Clinical Trial Summary

- 2D Echocardiography with color Doppler assessment: It will be done within 24 h after PPCI - Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level. - Follow up 2D Doppler echocardiography: will be repeated at 40 days of the event.

Clinical Trial Description

2D Echocardiography with color Doppler assessment: It will be done within 24 h after PPCI. Measurements will be as following: 1. Pulsed wave (PW) Doppler will be performed in the apical 4chamber view within a 3 mm sample volume at the tip of the mitral leaflets to obtain mitral inflow velocities to assess LV filling. 2. E (early diastolic)/A (late diastolic) - Using PW Doppler, the peak E and A velocities were recorded, then the ratio of E/A will be calculated. 3. IVRT (isovolumic relaxation time) - derived by placing the cursor of Continuous wave (CW) Doppler in the LV outflow tract to simultaneously display the end of aortic ejection and the onset of mitral inflow. 4. Deceleration time (DT) - from the peak of E wave to baseline. 5. E/e'- PW tissue Doppler imaging (TDI) was performed in the apical views to acquire mitral annular velocities. The sample volume will be positioned at or 1 cm within the mitral leaflet's septal and lateral insertion sites. 6. Left atrial volume and left atrial volume index (LAVI) - The maximal left atrial (LA) volume measured from the apical four-chamber view using the modified Simpson method in end-systole before mitral valve opening. The LAVI obtained for all patients by dividing the LA volume by the body surface area. Biochemical measurements: Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level. Follow up 2D Doppler echocardiography: All previous echocardiographic measurements will be repeated at 40 days of the event. ;

Study Design

Related Conditions & MeSH terms

Infarction
Myocardial Infarction
ST Elevation Myocardial Infarction
STEMI - ST Elevation Myocardial Infarction

Clinical Trial Details

NCT number	NCT05107076
Study type	Observational
Source	Assiut University
Contact	Mariam Hanna, Resident
Phone	+201069862210
Email	mariam.abdelmalak@yahoo.com
Status	Recruiting
Phase
Start date	November 2021
Completion date	May 2023

View Details

See also
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Withdrawn	`NCT04566289` - Observational Registry to Evaluate Real World Usage of PiCSO Impulse System in STEMI Patients as Part of Post-marketing Surveillance
Completed	`NCT04289012` - HELicobacter Pylori Screening in Patients With Acute Myocardial Infarction Pilot Study	N/A
Not yet recruiting	`NCT04185077` - Bivalirudin in Late PCI for Oatients With STEMI	Phase 4
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Completed	`NCT03677180` - National Cardiogenic Shock Initiative
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Recruiting	`NCT03863327` - EKG Criteria and Identification of Acute Coronary Occlusion
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Withdrawn	`NCT05497011` - A Study to Evaluate the Safety and Efficacy of PiCSO in Anterior STEMI Patients	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of PPCI on Diastolic Function & Levels of Galactin-3 in Patients With STEMI

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms