Human Immunodeficiency Virus (HIV) Clinical Trial
— HIV/TBOfficial title:
Integral Research of the Managing and Treatment of the Infection With Human Immunodeficiency (VIH) /Human Immunodeficiency Syndrome(SIDA) Co-infection With Latent Tuberculosis Infection. A Multidisciplinary and Interinstitucional Approach
The purpose of this study is to determine of once identified to the subjects infected with human immunodeficiency virus (positive VIH), to diagnose latent Tuberculosis, and to treat her with isoniazid for six months, measuring the production of Interferon range pre and posttreatment, to evaluate this way the result of the treatment on the immune response
Status | Active, not recruiting |
Enrollment | 100 |
Est. completion date | June 2013 |
Est. primary completion date | June 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Accept to participate. Informed consent. - Human Immunodeficiency Virus positive test, documented by Western Blot - Have not received treatment for latent tuberculosis - Have not been diagnosed pulmonary tuberculosis (Tbp) - Normal two chest X-rays, Postern-anterior and left lateral. Exclusion Criteria: - Active tuberculosis - Previous diagnosis of tuberculosis - Antecedent of treatment for active o latent tuberculosis - Contact with TB patient harboring Multidrug resistance or isoniazid resistant isolates of Mycobacterium tuberculosis. - Abnormal liver enzyme levels - Hemoglobin below 8 gr/dl - Allergy or intolerance to isoniazid - Peripheral neuropathy - Ingestion of drugs interacting with isoniazid |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Mexico | Instituto Nacional de Salud Publica | Mexico | Cuernavaca Morelos |
Mexico | Clínica Especializada CONDESA | Mexico City | D.F |
Lead Sponsor | Collaborator |
---|---|
Instituto Nacional de Salud Publica, Mexico | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto Nacional de Enfermedades Respiratorias |
Mexico,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Production of interferon gamma, in response to treatment of latent infection | Before and after treatment intake | Yes |
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