Stroke Clinical Trial
Official title:
Observational Study of the Polymorphisms of the Renin-angiotensin-aldosterone System and Their Relation to Resistant Systemic Arterial Hypertension and Adverse Cardiovascular Events
Renin-angiotensin-aldosterone system (RAAS) polymorphisms influence 24h arterial pressure
fluctuation. Resistant systemic arterial hypertension (RSAH) has an increased risk of end
organ damage and unfavourable prognosis, whereas pseudo-RSAH usually respond favourably to
drug therapy.
To prospectively investigate, in subjects with RSAH in a tropical South American city: 1)
Adverse cardiovascular events defined as fatal and non-fatal stroke or acute myocardial
infarction (AMI); and 2) the association of RAAS polymorphisms and adverse cardiovascular
events in this population.
Study population: 212 hypertensives recruited from primary care assistance (time since first
diagnosis of hypertension: 16.5±8.1 years) and without appropriate pressure control, between
2001 and 2006, corresponding to 0.48% of all hypertensives under care (18 new cases/year),
57±10 years old, 66% females. Under drug treatment schedule: three or more drugs including a
diuretic. Ninety two randomly selected hypertensives basis had renin-angiotensin-aldosterone
system genetic profile determined. Genetic assessment was carried out using a polymerase
chain reaction assay amplification technique. The following single nucleotide polymorphisms
were analyzed: renin (G1051A), angiotensinogen (M235T), angiotensin converting enzyme-ACE
(I/D), angiotensin II type 1 receptor (A1166C), aldosterone synthase (C344T) and
mineralocorticoid receptor (G3514C).
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
| Recruiting |
NCT03869138 -
Alternative Therapies for Improving Physical Function in Individuals With Stroke
|
N/A | |
| Completed |
NCT04034069 -
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
|
N/A | |
| Completed |
NCT04101695 -
Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects
|
N/A | |
| Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
| Completed |
NCT00391378 -
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
|
N/A | |
| Recruiting |
NCT06204744 -
Home-based Arm and Hand Exercise Program for Stroke: A Multisite Trial
|
N/A | |
| Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
| Active, not recruiting |
NCT04535479 -
Dry Needling for Spasticity in Stroke
|
N/A | |
| Completed |
NCT03985761 -
Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
|
N/A | |
| Recruiting |
NCT00859885 -
International PFO Consortium
|
N/A | |
| Recruiting |
NCT06034119 -
Effects of Voluntary Adjustments During Walking in Participants Post-stroke
|
N/A | |
| Completed |
NCT03622411 -
Tablet-based Aphasia Therapy in the Chronic Phase
|
N/A | |
| Completed |
NCT01662960 -
Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke
|
N/A | |
| Recruiting |
NCT05854485 -
Robot-Aided Assessment and Rehabilitation of Upper Extremity Function After Stroke
|
N/A | |
| Active, not recruiting |
NCT05520528 -
Impact of Group Participation on Adults With Aphasia
|
N/A | |
| Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
| Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
| Completed |
NCT05805748 -
Serious Game Therapy in Neglect Patients
|
N/A | |
| Recruiting |
NCT05621980 -
Finger Movement Training After Stroke
|
N/A |