Stroke Clinical Trial
Official title:
Prospective Observational Cohort Study for Early Detection of Arteriosclerosis
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes
mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe
complications like myocardial infarction, stroke or peripheral arterial occlusive disease.
In addition to life-style factors there is also a genetic predisposition to develop
complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.
About 300 patients who are treated for various conditions at the department of general
medicine at our hospital will be included prospectively in the study. This observational
cohort will be followed for at least 10 years follow-up examinations.
At baseline and during follow up visits detailed clinical phenotyping is planned (medical
and family history,standardized clinical and physical examinations, lab, RX, ECG,
stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes
collected at baseline.
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Observational Model: Cohort, Time Perspective: Prospective
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