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NCT ID: NCT04636125 Enrolling by invitation - Oral Antibiotics Clinical Trials

Prospective Evaluation of Oral Antibiotics for Treatment of Shoulder PJI

Start date: September 24, 2019
Phase: Phase 3
Study type: Interventional

Cutibacterium acnes (C. acnes) is an anaerobic aerotolerant bacteria commonly isolated during revision shoulder surgery. It is increasingly recognized as a pathogen, mainly in implant-related infections. As an anaerobe, it usually needs a prolonged culture incubation time of up to 14 days for growth and the association between implant surgery and C. acnes infection is not always obvious. Unfortunately, prolonged incubation also increases the risk of false positive cultures in isolating organisms that may exist as a result of contamination. Given high rates of positive C. acnes cultures in cases of both primary and revision shoulder surgery, the ramifications of positive C. acnes cultures for clinical decision making remains uncertain. The purpose of this study is to prospectively study the efficacy and side-effect profile of surgical treatment plus an oral antibiotic regiment for shoulder PJI with indolent organisms (C. acnes and CNS).

NCT ID: NCT04635540 Enrolling by invitation - Parkinson Disease Clinical Trials

Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease

Empathy
Start date: July 22, 2019
Phase: N/A
Study type: Interventional

This study evaluates an educational brochure tailored to caregivers of people with Alzheimer's disease, Parkinson's disease dementia, Lewy body disease, frontotemporal dementia, and vascular disease dementia. The goal of the brochure is educating caregivers about the decreased ability to detect emotion and decreased empathy that can be seen in dementia, increasing caregiver competence in providing care, and teaching caregivers ways to manage over time that lessens burden and improves quality of life.

NCT ID: NCT04630587 Enrolling by invitation - Dental Caries Clinical Trials

Longevity of Dental Fillings Utilizing 3D Printing

Start date: September 15, 2020
Phase: N/A
Study type: Interventional

The aim of the present study is to compare the success of dental fillings prepared using 3D printing technique to those manufactured with the direct composite technique. A total of 100 adult patients will be selected from dental patients attending Kaarina Municipal Health Care Centre from October 2020. The inclusion criteria are as follows: presence of multiple cavities, fractures or cosmetic demands on bilateral permanent teeth. The restorative demand should be a class II, III or IV on first or second molars, or premolars. At least two fillings should be from the same tooth group (premolar/molar) in each patient. This will be a split-mouth study, whereby one tooth on one side will be restored using direct technique, and the contra lateral tooth restored using the indirect technique through random allocation. For both direct and indirect restorations, commercially available short-fibre reinforced composite material (Ever X Flow, GC) is used for core material (replacing dentin) and flowable composite material (Gaenial Universal Injectable, GC) for surface (replacing enamel, appr. 2mm thickness from the surface), according the manufacturer´s instructions. Clinical evaluations will be conducted immediately after the final finishing, and after 1 year, 3 years and 5 years. The evaluation will be based on the United States Public Health Service (USPHS) criteria. Descriptive statistics will be used to describe the frequency distributions of the evaluated criteria. To analyse the failure rate for direct vs. indirect restorations, 2x2 tables will be created. Non-parametric statistical procedures will be used due to ordinally structured data for the assessment of the restorations. Mann-Whitney U-test will be used to explore significant differences at different time points between direct and indirect restorations.

NCT ID: NCT04611165 Enrolling by invitation - Clinical trials for Advanced Hepatocellular Carcinoma

Concurrent Nivolumab and External Beam Radiation Therapy for Patients With Advanced HCC

Nextrah
Start date: November 15, 2019
Phase: Phase 2
Study type: Interventional

To investigate the efficacy and safety of nivolumab for patients with advanced HCC undergoing EBRT

NCT ID: NCT04599192 Enrolling by invitation - Coronary Disease Clinical Trials

Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women

FiRST
Start date: April 19, 2019
Phase:
Study type: Observational [Patient Registry]

A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).

NCT ID: NCT04598139 Enrolling by invitation - Clinical trials for Medication Errors and Other Product Use Errors and Issues

Safer Use of Medication in Pediatric Patients at Home

Start date: May 5, 2021
Phase:
Study type: Observational

This study aims: - to develop a web-based notification system for caregivers of pediatric patients that allows to report medication errors and, based on this notification, and to share experiences and alerts about common errors of patients. - to assess de user satisfaction and perceived usefulness of the system. Participants: Parents with children who have required drug treatment in the last two months, who have an Internet connection and who agree to participate in the study. Sample size: 62 participants Main outcome variable: overall satisfaction

NCT ID: NCT04589819 Enrolling by invitation - Clinical trials for Stress Fracture of Tibia or Fibula

Fracture Recovery for Returning to Duty (Teriparatide STRONG)

Start date: December 8, 2022
Phase: Phase 4
Study type: Interventional

The project goals are to improve combat readiness of U.S. Soldiers and sustain the availability of the military to deploy by, 1) decreasing the number of days not physically ready for duty after diagnosis of a diaphyseal tibial stress fracture, 2) decreasing the need for a physical profile or medical discharge board after bone stress injury, and 3) decreasing the recurrence rates of bone stress injuries.

NCT ID: NCT04572711 Enrolling by invitation - Cholangiocarcinoma Clinical Trials

Prospective Evaluation of Biliary Tissue Sampling With ERCP

Start date: September 1, 2020
Phase:
Study type: Observational

The purpose of this study is to assess the safety, outcomes and performance characteristics of multiple biliary sampling techniques including but not limited to: single operator cholangioscopy (SOC) directed biopsies, transpapillary biliary biopsies (TPBx), brushings and bile aspiration for cytology and FISH in patients undergoing ERCP.

NCT ID: NCT04571658 Enrolling by invitation - Clinical trials for Focal Segmental Glomerulosclerosis

NEPTUNE Match Study

NEPTUNE Match
Start date: March 1, 2021
Phase:
Study type: Observational

NEPTUNE Match is an additional opportunity offered to NEPTUNE study participants to prospectively recruit and communicate patient-specific clinical trial matching with kidney patients and their physician investigators.

NCT ID: NCT04566913 Enrolling by invitation - Clinical trials for To Assess Bucco-lingual Dimension of the Ridge While Using Pontic Shield Technique as a Treatment Modality for Ridge Preservation

The Use Of Pontic Shield Technique For Alveolar Ridge Preservation . A Case Series

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

To assess bucco-lingual dimension of the ridge while using pontic shield technique as a treatment modality for ridge preservation