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The Recovery in Stroke Using PAP Study — RISE-UP  

Obstructive Sleep Apnea Clinical Trial

Official title:
The Recovery in Stroke Using PAP Study

Clinical Trial Summary

The proposed study is a randomized controlled trial among an anicipated 180 participants with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory polysomnography (PSG) comparing PAP treatment with usual care concerning the primary outcome of functional recovery.

Clinical Trial Description

This study has 4 aims: 3 main aims and an additional exploratory aim. Specific aim 1: Test whether PAP treatment for OSA in ischemic stroke improves stroke severity, post-stroke symptoms, post-stroke functional recovery (primary outcome), and quality of life. Specific aim 2: Determine whether acute vs. subacute initiation of PAP in ischemic stroke results in greater improvement in post-stroke outcomes (stroke severity, symptoms, stroke recovery, quality of life). Specific Aim 3: Conduct in-depth qualitative interviews with 25-30 stroke patients, family members, and acute care providers to elicit their experience with PAP use, including factors that influence adherence. Exploratory aim: Evaluate whether polysomnographic measures have prognostic utility in understanding the variability in stroke recovery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04130503
Study type Interventional
Source Yale University
Contact Radu Radulescu, MD
Phone 2033614037
Email radu.radulescu@yale.edu
Status Recruiting
Phase N/A
Start date September 1, 2019
Completion date December 31, 2024
View Details
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