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Obstructive Sleep Apnea clinical trials

View clinical trials related to Obstructive Sleep Apnea.

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NCT ID: NCT03189940 Completed - Obesity Clinical Trials

Lifestyle Modification Using an App in OSA

Start date: June 20, 2016
Phase: N/A
Study type: Interventional

This study aimed to investigate the effects of a mobile phone app linked to hospital electronic medical record (EMR) system on weight reduction and obstructive sleep apnea (OSA). Adults aged > 20 years with witnessed snoring or sleep apnea from a sleep clinic of a tertiary center were prospectively enrolled, and the participats were randomized into app user and control groups. The mobile app was designed to collect daily lifestyle data by wearing a wrist activity tracker and reporting dietary intake. At the visit after 2 weeks of use, a summary of the lifestyle was displayed on the hospital EMR and reviewed by both physicians and app users. Further lifestyle modification was encouraged on the basis of the electronically collected data. In the control group, the lifestyle modification performed as the usual practice. All participants underwent Watch PAT and body mass index (BMI) measurement twice: on enrollment; and after 4-weeks follow up. Changes of BMI, and parameters of sleep related breathing were analyzed.

NCT ID: NCT03186742 Completed - Clinical trials for Obstructive Sleep Apnea

Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy

Start date: July 1, 2014
Phase: Phase 4
Study type: Interventional

Obstructive sleep apnea syndrome (OSA) is the most frequent sleep disorder characterized by excessive decrease in muscle tone of the soft palate, the tongue and the posterior pharyngeal wall. It leads to airway collapse. In cases of decreased airway passage hypoventilation (hypopnea) occurs while periodic lack of airflow is called apnea. An obstructive sleep apnea syndrome is recognized as an independent cardiovascular risk factor. OSA is very common in patients with resistant hypertension. RAH is diagnosed when blood pressure remains elevated despite simultaneous use of 3 antihypertensive agents from different groups of drugs at optimal to maximum doses, including a diuretic. In patients with OSA frequent episodes of hypoxemia during sleep result in the repeated activation of the sympathetic nervous system. What is more, the episodes of respiratory disorders increases in levels of aldosterone serum concentration with following sodium and water retention and elevation of blood pressure finally. An increased aldosterone level also stimulates synthesis of collagen, promotes stiffening of the arterial wall, myocardial fibrosis with heart muscle remodeling and takes part in development of left ventricular hypertrophy (LVH) - common complication of hypertensive patients with OSA. Several studies, including the Sleep Heart Health Study have confirmed that severe OSA is associated with high prevalence of concentric hypertrophy through sympathetic activation and vasoconstriction. Eplerenone is a selective mineralocorticoid receptor inhibitor. It has no affinity for glucocorticoid, progesterone and androgen receptors and therefore has lower risk of side effects. Eplerenone lowers blood pressure and inhibits heart muscle fibrosis. The hypotensive effect is caused by reduction of fluid retention. Probably, in patients with OSA, a reduction of fluid accumulation especially at the level of the neck may contribute to lowering the resistance in the upper respiratory tract and in that way it may help to decrease the severity of OSA. As LVH remains a strong and independent predictor of total mortality and death from cardiovascular causes, in this study we want to assess whether the addition of Eplerenone to a standard antihypertensive therapy will favorably change left ventricular geometry. We also want to check if the addition the Eplerenone to a standard antihypertensive therapy could be an effective therapeutic option for patients with OSA and RAH.

NCT ID: NCT03160456 Completed - Clinical trials for Obstructive Sleep Apnea

Domiciliary Transcutaneous Electrical Stimulation in Obstructive Sleep Apnoea

TESLA-home
Start date: June 18, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to assess the efficacy of transcutaneous electrical stimulation of the pharyngeal dilator muscles in patients with obstructive sleep apnoea in the community compared to usual care, and follow the patients for three months, as well as to assess compliance of non-invasive electrical stimulation of the upper airway dilator muscles in obstructive sleep apnoea patients over time and evaluate the control of symptoms and improvement in quality of life.

NCT ID: NCT03156413 Completed - Clinical trials for Obstructive Sleep Apnea

The Evaluation of a Nasal Mask for the Treatment of Obstructive Sleep Apnea

Start date: May 29, 2017
Phase: N/A
Study type: Interventional

This investigation is designed to evaluate the performance as well as the patients overall acceptance of the mask.

NCT ID: NCT03154970 Completed - Clinical trials for Obstructive Sleep Apnea

Cervical Stabilization in Individuals With Obstructive Sleep Apnea

Start date: May 22, 2017
Phase: N/A
Study type: Interventional

This study will be performed in people with obstructive sleep apnea, in which one group will receive treatment with cervical stabilization for six weeks and the control group will receive treatment after the interval of six weeks

NCT ID: NCT03142438 Completed - Clinical trials for Obstructive Sleep Apnea

The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea

Start date: May 30, 2017
Phase: N/A
Study type: Interventional

This investigation is a prospective, non randomized, non blinded study. This investigation is designed to evaluate the performance, comfort and ease of use with the F&P trial full face and nasal mask amongst Obstructive Sleep Apnea (OSA) patients. Up to 70 OSA patients will be recruited from the North Texas Lung and Sleep Clinic (NTLSC) database

NCT ID: NCT03138993 Completed - Clinical trials for Obstructive Sleep Apnea

Improving Older Adults' Decision Making for OSAT

eDecide2Rest
Start date: May 22, 2017
Phase: N/A
Study type: Interventional

This study evaluates the feasibility of conducting a randomized controlled trial that tests a patient decision aid for obstructive sleep apnea in older adults with newly-diagnosed obstructive sleep apnea treated in an outpatient sleep clinic. Half of the participants will use a patient decision aid, while the other half will receive general information about sleep.

NCT ID: NCT03128177 Completed - Hypertension Clinical Trials

Nocturnal Hypertension and Non-Dipping Blood Pressure

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. The investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. The study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. A total of 60 participants will be enrolled in the study.

NCT ID: NCT03124069 Completed - Clinical trials for Obstructive Sleep Apnea

A Development Study to Evaluate a Nasal Mask for the Treatment of Obstructive Sleep Apnea

Start date: April 24, 2017
Phase: N/A
Study type: Interventional

This investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.

NCT ID: NCT03122483 Completed - Clinical trials for Obstructive Sleep Apnea

Use of Blood Biomarkers and Biomarker Index to Aid in the Diagnosis of Obstructive Sleep Apnea (OSA)

Start date: January 2016
Phase: N/A
Study type: Observational

This multicenter prospective trial will evaluate the association between obstructive sleep apnea (OSA) and blood biomarkers in a representative population of consecutively enrolled symptomatic patients with a clinical suspicion of OSA.