Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.

Obesity Clinical Trial

Official title:

Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06450847
• Other study ID #: USharjah1
• Status: Not yet recruiting
• Phase: N/A
• Start date: June 2024
• Est. completion date: October 2024

Study information

• Verified date: May 2024
• Source: University of Sharjah
• Contact: Amenah Abdelazim, BPT
• Phone: +971554590707
• Email: aabdelazim[@]sharjah.ac.ae
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study aims to investigate the impact of Soleus Push Ups (SPU) on Soleus Muscle endurance, Oxidative Stress Markers, Inflammatory markers and Adipocytokines among people in the United Arab Emirates. This will be a pre-post intervention study with participants divided into three groups: Lean normal metabolic profile, metabolically healthy overweight/obese, and patients with Type 2 Diabetes Mellitus. Assessment of anthropometry and body composition, Soleus Muscle Endurance, blood tests for Inflammatory Markers, Oxidative Stress Markers, and Adipocytokines will be conducted pre and post-intervention.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 72
• Est. completion date: October 2024
• Est. primary completion date: September 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• Residents of UAE, both males and females
• Ages 20-50 years
• Uncomplicated Type 2 Diabetic on meds,
• Normal lean BMI
• Overweight and Obese

Exclusion Criteria:

• Recent orthopedic surgery in the LLs
• Pain in the LLs starting from Hips to Ankle.
• Presence of Varicose Veins in the LLs
• Present History of any cardiovascular condition
• Pregnant females
• Morbid Obesity
• Diabetics undergoing Insulin therapy only
• Smokers and alcohol consumption

Related Conditions & MeSH terms

• Diabete Type 2
• Diabetes Mellitus, Type 2
• Obesity
• Overweight

Intervention

Other:
• Soleus Muscle Push Up Exercise
Members will be asked to do the SPUs for 270 minutes/day for most days of the week (minimum 5 days) for 3 months: Begin seated on a bench or chair so knees form a 90-degree angle with feet flat on the floor and toes pointed forward. Keep spine straight and shoulders back (not hunched or rounded forward). Using a slow and controlled tempo, push toes into the floor and lift heels off the ground. Hold for one to two seconds, pushing down on the balls of feet. Keep your thigh muscles relaxed. Slowly lower heels and return to start. That's 1 rep. Without shoes Educational session will be given before the intervention time WhatsApp messages will be sent 1-2 times/day to remind the participants to continue doing the exercise and ascertain compliance. Also, the participants are required to daily fill logbook about the duration (in minutes) of the SPU that they did.
• Other Exercise
Participants will be asked to continue their regular lifestyle

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Sharjah

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	BMI	kg/m2	3 months
Other	Anthropometric data including weight, height and fat percentage	Measured in kgs, cms and % respectively	3 months
Other	Physical Activity and Food habits	Questionnaire (International Physical Activity Questionnaire and Food Frequency Questionnaire)	3 months
Other	Venous blood specimens	Measured in mL, using blood test by specialized personnel	3 months
Primary	Adipocytokine levels in the blood	Measured in µg/ml, using blood test by specialized personnel	3 months
Secondary	Soleus Muscle endurance through Heel Raise Test. • Inflammatory and Oxidative Stress markers through blood sample.	Measured as a number, in repetitions. Detailed procedure described previously.	3 months