Global Research Initiative for Patients Screening on NASH — GRIP on NASH  

Obesity Clinical Trial

Official title: Global Research Initiative for Patients Screening on NASH - Implementation of an International Transmural Patient Care Pathway

Status Not yet recruiting

Clinical Trial Summary

GRIP on NASH will assist primary care physicians and clinicians to implement the latest patient care pathway, as described by the European Association for the Study of the Liver (EASL), to identify patients at risk of severe fatty liver disease and to raise awareness on fatty liver disease. The primary objective is to implement a transmural patient care pathway, in order to identify patients with non-alcoholic fatty liver diseases (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) in primary care centres and clinics in 10 European countries.

Clinical Trial Description

GRIP on NASH is an observational study in which 10.000 high risk patients (type 2 diabetes mellitus, metabolic syndrome, obesity or arterial hypertension) in 10 different European countries will be screened for the presence of non-alcoholic fatty liver disease and liver fibrosis using two non-invasive tests (FIB-4 and FibroScan). Blood samples and liver biopsy material will be collected. Genomic, proteomic, metabolomic and lipidomic studies will be applied to gain a better understanding of the pathophysiology of non-alcoholic fatty liver disease and to identify (bio)markers that will help to detect patients at risk. The predictive value of FIB-4 in relation to FibroScan results and liver biopsy will be analysed. Long-term follow-up of 5 years in all participants will provide insight into the natural history of the disease. ;

Related Conditions & MeSH terms

• Arterial Hypertension
• Fatty Liver
• Fibrosis
• Fibrosis, Liver
• Hypertension
• Liver Cirrhosis
• Metabolic Syndrome
• NAFLD
• NASH
• Obesity
• Steatosis of Liver
• Type 2 Diabetes

• NCT number: NCT05651724
• Study type: Observational [Patient Registry]
• Source: Julius Clinical
• Contact: Vivian D de Jong, MSc
• Phone: +31628259968
• Email: vivian.dejong@juliusclinical.com
• Status: Not yet recruiting
• Start date: January 1, 2023
• Completion date: March 31, 2031