The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients With Type 2 Diabetes

Obesity Clinical Trial

Official title:

The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients With Type 2 Diabetes

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05078255
• Other study ID #: U1111-1259-1491
• Status: Recruiting
• Phase: N/A
• Start date: January 27, 2022
• Est. completion date: October 2024

Study information

• Verified date: February 2023
• Source: University Hospital, Gentofte, Copenhagen
• Contact: Mads M Helsted, MD
• Phone: +4538673801
• Email: mads.marstrand.helsted[@]regionh.dk
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Due to reports of a severely reduced insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) in type 2 diabetes (T2D), GIP has not been considered therapeutically viable in T2D. Recently, however, tirzepatide, a novel dual incretin receptor agonist (activating both the GIP receptor and the glucagon-like peptide 1 (GLP-1) receptor) demonstrated massive improvements in glycaemic control and robust body weight losses; greater than observed with the GLP-1 receptor agonist semaglutide. However, the contribution of GIP receptor activation to these effects remains unknown. The present study will evaluate the glucose-lowering effect of GIP in the context of pharmacological GLP-1 receptor activation in patients with T2D.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: October 2024
• Est. primary completion date: May 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 74 Years

Eligibility

Inclusion Criteria:

1. Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial

2. Men and women 18 to 74 years of age (both inclusive) at the time of signing informed consent

3. Diagnosed with type 2 diabetes for at least six months

1. Treated with diet and exercise and/or stable metformin and/or sodium-glucose cotransporter 2 (SGLT-2) inhibitor and/or dipeptidyl-peptidase 4 inhibitor (DPP-4i) and/or sulfonylureas (SU) treatment for at least 3 months If treated with DPP-4i and/or SU, this treatment must be paused for 14 days prior to first CGM period in the trial

2. HbA1c =48 to =91 mmol/mol

4. BMI =25 to =50 kg/m2

5. Stable body weight (less than 3 kg self-reported change during the previous 90 days) Exclusion Criteria: For an eligible participant, all exclusion criteria must be answered "no".

1. Diagnosed with type 1 diabetes

2. Known or suspected hypersensitivity to trial product or related products

3. Acute decompensation of glycaemic control requiring immediate intensification of treatment to prevent acute complications of diabetes (e.g. diabetes ketoacidosis) which required help from doctor or hospitalisation within 90 days prior to screening

4. Previous participation in this trial. Participation is defined as signed informed consent. Participation is allowed if the protocol is updated to a newer version

5. Participation in another clinical trial within 90 days before screening

6. Woman who are pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive methods (intrauterine devices or hormonal contraception (oral contraceptive pills, implants, transdermal patches, vaginal rings or long-acting injections))

7. If previously treated with GLP-1RA, information about the time and reason for stopping will be collected. Based upon this, the eligibility will be judged by the investigator

8. Participation in an organised weight reduction programme within 3 months before screening

9. Any disorder which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol

10. Anticipated change in lifestyle (e.g. smoking, eating or exercise pattern) during the trial

11. Any laboratory safety parameter at screening outside the below extended laboratory ranges, see laboratory manual for specific values

• Albumin outside lower normal limit (LNL) -5% and upper normal limit (UNL) +5%
• Alanine aminotransferase (ALT) outside LNL -100% and UNL +50%
• Creatinine outside UNL +10%
• Haemoglobin outside LNL -5% and UNL +10%
• Leukocytes outside LNL -20% and UNL +20%
• Thrombocytes outside LNL -15% and UNL +15%
• Bilirubin (total) outside UNL +15%
• Amylase = UNL +100%

12. Untreated or uncontrolled hypothyroidism/hyperthyroidism defined as thyroid-stimulating hormone (TSH) <0.4 mIU/L or > 6 mIU/L

13. Obesity related to endocrinologic disorders (e.g. Cushing Syndrome)

14. Any blood draw in excess of 25 mL in the past month, or donation of blood or plasma in excess of 400 mL within the 90 days preceding screening

15. Use of any prescription or non-prescription medication (apart from oral contraceptives, routine vitamins, occasional use of paracetamol, acetylsalicylic acid, or ibuprofen) which could interfere with pharmacokinetic or pharmacodynamic results,

as judged by the investigator, such as:

• herbal products and non-routine vitamins
• Glucose lowering medication (except metformin)
• medication that may cause weight gain, including systemic corticosteroids, tricyclic antidepressants, and atypical antipsychotics
• orlistat, zonisamide, topiramate, phentermine, lorcaserin, bupropion, naltrexone or other weight loss drugs
• Blood pressure and lipid lowering agents (e.g. statins) drugs are allowed if treatment has been stable for = 1 month prior to screening and treatment should preferably be kept unchanged during the trial

16. Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2

17. History of pancreatitis (acute or chronic)

18. History of major depressive disorder or other severe psychiatric disorders, e.g. schizophrenia or bipolar disorder within the last 2 years or lifetime history of suicide attempt

19. Surgery scheduled for the trial duration period, except for minor, non-gastrointestinal surgical procedures at the discretion of the investigator

20. Sitting blood pressure (after resting for at least 5 minutes) =160 mmHg systolic or = 100 mmHg diastolic or heart rate of = 90 beats/min after resting for at least 5 minutes (if white-coat hypertension is suspected, one repeat measurement is allowed; last measure being conclusive and to be recorded in the case report form (CRF))

21. Cancer (past or present, except basal cell skin cancer or squamous cell skin cancer), which in the investigator's opinion could interfere with the results of the trial

22. Known or suspected alcohol abuse within 1 year from screening (defined as regular intake of more than 14 units weekly for men and 7 units weekly for women - one unit of alcohol equals about 300 mL of beer or lager, one glass (100 ml) of wine, or 25 ml spirits) or a positive result of an alcohol test

23. Known or suspected drug/chemical substance abuse within 1 year from screening

24. Inability or unwillingness to perform self-injection at the screening visit (with a placebo test pen)

25. Mental incapacity, language barriers or unwillingness to comply with the requirements of the protocol, which may preclude adequate understanding or co-operation during the trial, as judged by the investigator

26. Investigator, any sub-investigators, research assistants, pharmacist, trial coordinators, other staff, sponsor staff or relatives thereof directly or indirectly involved in the conduct of the trial cannot participate in the trial

Related Conditions & MeSH terms

• Diabetes Mellitus
• Diabetes Mellitus, Type 2
• Obesity
• Type 2 Diabetes

Intervention

Drug:
• Semaglutide 1.34 MG/ML [Ozempic]
Semaglutide 1.34 mg/ml
• Glucose-dependent insulinotropic polypeptide (GIP)
GIP

Other:
• Semaglutide 1.34 mg/ml placebo
Saline
• GIP placebo
Saline

Locations

Country	Name	City	State
Denmark	Center for Clinical Metabolic Research, Gentofte Hospital	Hellerup	Capital Region

Sponsors (1)

Lead Sponsor	Collaborator
Filip Krag Knop

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mean glucose levels (assessed by blinded continuous glucose monitoring (CGM))	The primary outcome is change in 14-day mean glucose levels (assessed by CGM) during the last 14 days of the intervention period as compared to 14-day mean glucose levels during the last 14 days of the run-in period.	14-day mean glucose levels during the last 14 days of the intervention period as compared to 14-day mean glucose levels during the last 14 days of the run-in period.