Obesity Clinical Trial
A growing number of cross-sectional studies is investigated the role of the human lipidome as
a new biomarker for metabolic diseases. However, data on this issue is still sparse and
especially interventional data is not available up to now.
"GesundLeben" will provide data on 100 human subjects with metabolic syndrome, undergoing
distinct types of lifestyle intervention for 6 weeks. Standardized metabolic assessment will
be covered with routine laboratory parameters and oral glucose tolerance test as well as
non-radiologic anthropometric measurements.
A growing number of cross-sectional studies is investigated the role of the human lipidome as
a new biomarker for metabolic diseases. However, data on this issue is still sparse and
especially interventional data is not available up to now. We intend to clarify, if the human
lipidome is correlating with metabolic state and if changes in this state reflect on the
lipidome. Using high-throughput shot-gun technique, we will be able to measure several
hundreds of lipid species in one blood sample.
The "GesundLeben" trial will provide data on 100 human subjects with metabolic syndrome,
undergoing distinct types of lifestyle intervention for 6 weeks. The cohort will be designed
to include participants from both sexes, but be restricted on subjects without impaired
glucose tolerance.
Standardized metabolic assessment will be covered with routine laboratory parameters (e.g.
transaminases, HbA1c) and oral glucose tolerance test as well as non-radiologic
anthropometric measurements (BMI, WHR, BIA).
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