Obesity Clinical Trial
Official title:
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM)
The purpose of this study is to discover the characteristics of pregnant women which increases risk for their babies to develop diabetes, later on in life.
Obesity has been recently diagnosed in a younger population and currently in the United
States more than two thirds of women of childbearing age are overweight or obese. These women
will have children at high risk for developing obesity and Type 2 diabetes (T2DM). There is
an acute need for preventing these complications in children so that we can break the cycle
of obesity and T2DM. Numerous interventions have attempted but failed to improve outcomes in
obese pregnancies by weight loss. Clinicians do not currently have specific recommendation
for identifying the obese mothers and risk and for the prevention of infant's complication in
healthy obese pregnancies.
The global objective of this study is to identify the relevant maternal phenotype at risk and
the mechanism(s) of fetal environment predisposing the offspring for T2DM. This will enhance
T2DM early screening and prevention.
The global hypothesis is that dysfunctional adipose tissue secretes angiostatic and
pro-inflammatory factors that lead to the formation of a dysfunctional placenta, which
through a hypoxic and inflamed environment alters the epigenome to program the fetus for
T2DM.
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