Obesity Clinical Trial
Official title:
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women
In this study, we will clarify the degree of insulin resistance and characterise muscle
glucose metabolism and gene expression in a group of overweight healthy women. The study
will clarify how overweight influences body glucose metabolism and thereby in the long-run
increases the risk for developing type 2 diabetes. Moreover, the study may clarify why some
overweight women develop hormone disorders and diabetes while others remain healthy.
The study is essential as many patients suffer from diseases aggravated by overweight. In
addition, a genetic disposition for diabetes or polycystic ovary syndrome may give rise to
the disease if the patient gains weight. It is therefore important that weight-matched
control subjects are included in projects with overweight patients.
This clinical trial includes 10 overweight women with regular hormones and normal level of
male sex hormone. The patients included must be healthy, take no medications influencing the
study results. The subjects must take no contraceptive pills or receive any other hormone
treatment.
In connection with the investigation, the following will be carried out on all patients:
clinical examination, blood tests, hyperinsulinaemic euglycaemic clamp, muscle biopsies,
bone scan.
The purpose of the study is to gain more knowledge of how overweight influences women's risk
of developing hormone diseases and diabetes.
n/a
Time Perspective: Prospective
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