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Nonalcoholic Fatty Liver Disease clinical trials

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NCT ID: NCT02684591 Completed - HIV Clinical Trials

Aramchol for HIV-associated Nonalcoholic Fatty Liver Disease and Lipodystrophy

ARRIVE
Start date: January 2016
Phase: Phase 2
Study type: Interventional

A subset of patients with NAFLD that have not been extensively studied are those infected with human immunodeficiency virus (HIV). Currently, there is no FDA approved treatment for NAFLD or NASH. Additionally, there have been no significant clinical trials for HIV patients with NAFLD and there are no approved treatment options. We plan to conduct a randomized, double-blinded, placebo-controlled clinical trial to examine the efficacy of 600 mg of Aramchol daily (including 200 mg tablet and 400 mg tablet) versus identical placebo given over 12 weeks to improve HIV-associated hepatic steatosis as measured by a validated and accurate magnetic resonance imaging (MRI)-based technique.

NCT ID: NCT02513121 Completed - Clinical trials for Nonalcoholic Fatty Liver Disease

Dietary Treatment Study of Pediatric NAFLD

DTS
Start date: July 2015
Phase: N/A
Study type: Interventional

This is an investigator initiated study being conducted in equal numbers at two sites, University of California, San Diego (UC San Diego) and Emory University (EU). The purpose of this study is to understand the potential of a low sugar diet for the treatment of nonalcoholic fatty liver disease (NAFLD) in children. Forty boys with NAFLD will be randomly assigned to either an intervention group or a habitual diet control group. The intervention will be a low sugar diet for a period of 8 weeks. The effect of this dietary change will be assessed using advanced magnetic resonance imaging (MRI) testing to measure liver fat.

NCT ID: NCT02412540 Completed - Obesity Clinical Trials

Controlled Trial of WLS vs. CLI for Severely Obese Adolescents With NASH

Start date: April 23, 2015
Phase: N/A
Study type: Interventional

The goal of this study is to determine effective treatment and identify diagnostic biomarkers for Nonalcoholic steatohepatitis (NASH). Individuals that take part in the study will be participating in either a weight loss surgery (WLS) group or a comprehensive lifestyle intervention (CLI) group. People in the WLS group will receive vertical sleeve gastrectomy (VSG). The CLI group will receive dietary, activity and behavioral interventions provided by trained study staff.

NCT ID: NCT02132780 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease

AD-NAFLD
Start date: May 2014
Phase: N/A
Study type: Observational

There is a significant association between autonomic dysfunction and symptoms experienced by NAFLD patients mediated by increased systemic inflammation and insulin resistance, resulting in deteriorating quality of life of affected patients; fatigue and other symptoms drive worsening autonomic dysfunction in these patients. We aim to describe the severity of autonomic dysfunction (AD) in non-alcoholic fatty liver disease (NAFLD) and the relationship of AD to symptoms experienced by NAFLD patients (such as fatigue, chronic pain, depression, sleep disturbance, and cognitive dysfunction), and to the quality of life of NAFLD patients. We also hope to examine the impact of systemic inflammation and insulin resistance as mediators of manifestations of AD and symptoms experienced by NAFLD patients.

NCT ID: NCT02132442 Completed - Type 2 Diabetes Clinical Trials

Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Diabetes

VDLS
Start date: March 2014
Phase: Phase 3
Study type: Interventional

This study is designed to study the effect of vitamin D intake on the severity of fatty liver and poor glucose control in patients with type 2 diabetes and fatty liver disease.

NCT ID: NCT02117700 Completed - Obesity Clinical Trials

Fatty Liver Disease in Obese Children

Start date: April 2015
Phase: Phase 1/Phase 2
Study type: Interventional

Although weight reduction through physical activity-based interventions is the mainstay therapy for nonalcoholic fatty liver disease (NAFLD), its maintenance is difficult and typically unsuccessful. This affirms the extreme need for alternate and/or adjunct therapies. Although convincing data from animal studies and a few adult human studies on the benefits of a natural product, N-acetyl cysteine (NAC), in a variety of liver conditions including NAFLD have emerged, studies in children are scarce. Therefore, the aim of the study is to test the use NAC as an innovative approach to attenuate the progression of NAFD in obese children with biopsy proven NASH. The central hypothesis is that NAC supplementation will reduce liver fat and liver enzymes and ameliorate risk factors of cardiometabolic disease in children with NAFLD.

NCT ID: NCT02018237 Completed - Obesity Clinical Trials

High Fructose Corn Syrup

Fructose
Start date: March 2012
Phase: N/A
Study type: Interventional

The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.

NCT ID: NCT01940263 Completed - Clinical trials for Nonalcoholic Fatty Liver Disease

Purified Anthocyanin and Nonalcoholic Fatty Liver Disease

Start date: June 2013
Phase: Phase 0
Study type: Interventional

Oxidative stress and inflammation are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Anthocyanins from different plant foods have been shown to improve features of experimental NASH, such as oxidative stress, dyslipidemia, liver steatosis, and inflammation in rodents. The purpose of this study is to investigate whether purified anthocyanin supplementation beneficially alters oxidative, inflammatory, and apoptotic biomarkers in adults with features of NAFLD.

NCT ID: NCT01934777 Completed - Obesity Clinical Trials

Efficacy and Tolerance of Treatment With DHA, Choline and Vitamin E in Children With Non-alcoholic Steatohepatitis

Start date: October 2013
Phase: Phase 3
Study type: Interventional

The purpose of this interventional study is to evaluate the efficacy and tolerability of docosahexaenoic acid (DHA), Vitamin E and Choline in children or adolescents with well-characterized and liver biopsy confirmed nonalcoholic fatty liver disease (NAFLD).

NCT ID: NCT01828528 Completed - Clinical trials for Nonalcoholic Steatohepatitis

Impact of Bariatric Surgery on Nonalcoholic Fatty Liver Disease

Start date: April 2013
Phase: N/A
Study type: Observational

The purpose of this study is to investigate the effect of weight loss rate on liver steatosis, steatohepatitis, fibrosis and cardiovascular risk at different stages before and after bariatric surgery. The investigators also aim to study the short-term effect of bariatric surgery on gastric cholecystokinin levels before and 10 days after the bariatric surgery.