Mechanisms of Myocardial Infarction in Women With Non Obstructive Coronary Artery Disease

Myocardial Infarction Clinical Trial

Official title:

Mechanisms of Myocardial Infarction in Women With Non Obstructive Coronary Artery Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01953029
• Other study ID #: 0541-12-RMB
• Status: Not yet recruiting
• Phase: N/A
• First received: September 23, 2013
• Last updated: September 25, 2013
• Start date: December 2013
• Est. completion date: October 2018

Study information

• Verified date: September 2013
• Source: Rambam Health Care Campus
• Contact: Miry Blich, MD
• Phone: 972-4-8543478
• Email: m_blich[@]rambam.health.gov.il
• Is FDA regulated: No
• Health authority: Israel: Ethics Commission
• Study type: Observational

Clinical Trial Summary

The objective of our work to determine the mechanisms of myocardial infarction in women without obstructive coronary artery disease.

Description:

Cardiovascular disease is the leading cause of death for women. Acute coronary syndrome (ACS) is usually characterized by a sudden erosion of the endothelial wall or rupture of a plaque.However, women with ACS are less likely than men to have either classic symptoms or obstructive coronary artery disease but paradoxically have a worse prognosis. Different data from the literature indicate that there may be different pathophysiological mechanisms, afflicting men and women somewhat differently.Between 5% and 30% of patients with ACS undergoing coronary angiography are found to have non visible or non obstructive coronary disease (NOCD). This is 2-3 times more common in women than in men. Several pathogenetic mechanism of myocardial infarction (MI) in the absence of obstructive coronary artery disease (OCD) have been postulated, including among others atherosclerosis with plaque disruption that does not lead to luminal occlusion ,endothelial dysfunction, vasospasm , distal microembolization and microvascular dysfunction. However the data are extremely limited.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 80
• Est. completion date: October 2018
• Est. primary completion date: October 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Women = 18 years old, not pregnant

• with acute non ST elevation myocardial infarction (admitted within 12 hours from beginning of symptoms)

• who are candidates for coronary arteriography during the hospitalization. -

Exclusion Criteria:

*Women with troponin elevation caused by other causes -

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Infarction
• Myocardial Infarction
• Myocardial Ischemia

Intervention

Procedure:
• cardiac imajing
Cardiac MRI

Locations

Country	Name	City	State
Israel	Rambam Heath Care Campus	Haifa

Sponsors (1)

Lead Sponsor	Collaborator
Rambam Health Care Campus

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MORTALITY		1 YEAR	Yes