Karolinska Cardiorenal Theme-centre and StockholmHeartbank — KKT  

Myocardial Infarction Clinical Trial

Official title: Stockholmheartbank and Karolinska Cardiorenal Theme-centre, From Genome to Clinical Practice in Patients With Acute Coronary Syndrome and Impaired Kidney Function

Status Recruiting

Clinical Trial Summary

Chronic kidney disease (CKD) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death. In patients with ischemic heart disease 26% have increased creatinine, which rises to 40% if patients also have diabetes mellitus. Risk increases as renal function diminishes, and just slowing the rate of decline in renal function would have a tremendous impact on health and morbidity. This association is commonly termed the Cardiorenal Syndrome, though it is caused by a much more complex interplay between major pathogenetic pathways such as glucose metabolism and diabetes, systemic and tissue inflammation, tissue metabolism, coagulation, mineral metabolism, sympathetic activation, renin-angiotensin-aldosterone system activation, endothelial dysfunction, lipid metabolism, fetal programming etc.

Karolinska Institutet recently merged basic and clinical researchers in all these fields, creating a Karolinska Kardiorenal Theme Centre; ultimately aiming to explore the syndrome and provide improved care for the individual patient.

The investigators road to success:

• Creating a Biobank (blood, DNA, plasma) from the majority of all hosptalized patients with ACS in Stockholm county - Stockholmheartbank.

• This Theme Center include all teaching hospitals associated with Karolinska Institutet; Danderyd University Hospital, Karolinska University Hospital and Södersjukhuset University Hospital. Together theses hospitals serve as emergency hospitals for 1.9 million people. The investigators are aiming at creating a biobank from all patients admitted for an acute coronary event (about 2.300/yr), which is a unique asset for molecular and genetic research as well as observational and intervention studies.

• The investigators have access to the National registry with 100% coverage, that contains data on all patients admitted to Stockholms coronary care units since 1995.

• To ensure translation in to clinical practice, most of the researchers are also MD:s, and several are clinically active.

• The clinical network facilitates the development of novel therapies and translational research.

• Steering groups for Education and a Clinical Practice implementation program.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Chronic Kidney Disease
• Chronic Renal Failure
• Coronary Artery Disease
• Heart Diseases
• Infarction
• Ischemic Heart Disease
• Kidney Diseases
• Kidney Failure, Chronic
• Myocardial Infarction
• Myocardial Ischemia
• Renal Insufficiency
• Renal Insufficiency, Chronic
• Syndrome

• NCT number: NCT01204645
• Study type: Observational
• Source: Danderyd Hospital
• Contact: Jonas Spaak, MD, PhD
• Phone: +46 762014178
• Email: jonas.spaak@ki.se
• Status: Recruiting
• Phase: N/A
• Start date: May 2010
• Completion date: January 2024