Myocardial Infarction Clinical Trial
Official title:
Genome-Wide Case-Only Study of Antihypertensive Drug-Gene Interactions
Verified date | November 2016 |
Source | University of Washington |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
High blood pressure is one of the most common health problems in the United States. There are many drug treatment options for high blood pressure, but these medications are not always effective. People with treated high blood pressure can still suffer from other serious cardiovascular health problems, including heart attack, sudden death, or stroke. Genetic variations may cause some people to be more susceptible to these cardiovascular outcomes despite treatment. This study will identify new gene regions that may influence the effectiveness of high blood pressure drugs in preventing the above mentioned cardiovascular conditions.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | November 2016 |
Est. primary completion date | November 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 30 Years to 79 Years |
Eligibility |
Inclusion Criteria: - Experience of a first heart attack, stroke, or sudden death - Member of the Group Health Center (GHC) treated for high blood pressure - Enrolled at least 1 year in one of the three study populations - Treated for high blood pressure with one of the four major classes of high blood pressure drugs (diuretics, beta-blockers, ACE inhibitors, or calcium antagonists) |
N/A
Country | Name | City | State |
---|---|---|---|
United States | Cardiovascular Health Research Unit | Seattle | Washington |
Lead Sponsor | Collaborator |
---|---|
University of Washington | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genomic regions for each of the four major drug classes that influence drug and gene interaction | Measured at completion of genetic analysis | No | |
Secondary | Ethnic-specific genetic variations for each of the four major drug classes that influence drug and gene interaction | Measured at completion of genetic analysis | No |
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