Muscle Protein Synthesis Clinical Trial
Official title:
The Effects of Varying Essential Amino Acid Intakes on Resting and Post-exercise Skeletal Muscle and Whole-body Protein Kinetics During Negative Energy Balance
Verified date | October 2020 |
Source | United States Army Research Institute of Environmental Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined. This study will address that gap in knowledge by examining the resting and post-exercise muscle and whole-body protein kinetic responses to ingesting varying amounts of EAA after a 5 day period of negative energy balance. This study will provide the initial evidence to support the development of a recovery-based food product for military combat rations.
Status | Completed |
Enrollment | 20 |
Est. completion date | March 20, 2019 |
Est. primary completion date | March 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Men and women aged 18 - 35 years - Body mass index < 30.0 kg/m2 - Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO) - Resistance exercise trained defined by self-report as performing = 2 sessions/wk for previous 6 mo - Refrain from taking any nonsteroidal anti-inflammatory drugs (e.g., aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product for 10 days before starting and at least 5 days after completing the study - Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine, and dietary supplement use throughout the entire study period - Supervisor approval for federal civilian employees and non-HRV active duty military personnel working within the US Army Natick Soldier Systems Center Exclusion Criteria: - Musculoskeletal injuries that compromise exercise capability as determined by the USARIEM Office of Medical Support and Oversight (OMSO) - Metabolic or cardiovascular abnormalities, gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.) - Abnormal PT/PTT test or problems with blood clotting - History of complications with lidocaine - Present condition of alcoholism, anabolic steroids, or other substance abuse issues - Blood donation within 8-wk of beginning the study - Pregnancy (self-report or results of urine pregnancy test before body composition testing) - Unwillingness or inability to consume study diets or foods provided |
Country | Name | City | State |
---|---|---|---|
United States | US Army Research Institute of Environmental Medicine | Natick | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
United States Army Research Institute of Environmental Medicine | Eastern Michigan University, University of Arkansas |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postprandial, Resting Muscle Protein Synthesis Rates | Assessed using stable isotope infusions of phenylalanine. | 3 hour measure of muscle protein synthesis | |
Primary | Postprandial, Post-exercise Muscle Protein Synthesis Rates | Assess using stable isotope infusions of phenylalanine. | 3 hour measure of muscle protein synthesis | |
Primary | How Well Participants Suppress the Degradation of Body Proteins While Stimulating the Growth of New Proteins After Ingesting Varying Doses of EAA at Rest and After Exercise. Net Whole-body Protein Balance | Assessed using stable isotope infusions of tyrosine. Net Whole-body Protein Balance is defined as whole-body protein synthesis - whole-body protein breakdown) | 3 hour measure of whole-body protein balance |
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