Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

Muscle Protein Synthesis Clinical Trial

Official title:

Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02732353
• Other study ID #: H-15012327
• Status: Not yet recruiting
• Phase: N/A
• First received: March 30, 2016
• Last updated: November 7, 2016
• Start date: November 2016
• Est. completion date: March 2018

Study information

• Verified date: November 2016
• Source: Bispebjerg Hospital
• Contact: Kasper Dideriksen, PhD
• Phone: +45 35313948
• Email: kasperjuel[@]hotmail.com
• Is FDA regulated: No
• Health authority: Denmark: The Danish National Committee on Biomedical Research Ethics
• Study type: Interventional

Clinical Trial Summary

To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males. Moreover, the basal muscle protein synthesis and the postprandial muscle protein synthetic response to minced beef and hydrolyzed beef ingestion are measured in young males. The postprandial muscle protein synthetic response is measured and compared during the early postprandial period (0-3 hours) after ingestion of the two meat products.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 10
• Est. completion date: March 2018
• Est. primary completion date: March 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy

• Non-obese (BMI<30)

Exclusion Criteria:

• Chronic medical disease

• >5 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Meat Protein Supplements
• Muscle Protein Synthesis
• Protein Absorption and Amino Acid Availability

Intervention

Dietary Supplement:
• Minced beef
Cow meat protein supplement
• Hydrolyzed beef
Cow meat protein supplement

Locations

Country	Name	City	State
Denmark	Bispebjerg Hospital	Copenhagen NV

Sponsors (1)

Lead Sponsor	Collaborator
Kasper Dideriksen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in skeletal muscle protein fractional synthetic rate	The fractional synthetic rate of skeletal muscle proteins (%/h) measured during the overnight fasted state and the postprandial state.	During the postprandial period (0-3 hrs).	No
Secondary	Protein absorption	The change in venous plasma ring-2H5-phenylalanine enrichment after ingestion of meat protein, reflects the protein absorption from the meat protein products.	During the postprandial period (0-3 hrs).	No
Secondary	Plasma amino acid concentration	Change in venous plasma amino acid concentration after ingestion of meat protein.	During the postprandial period (0-3 hrs).	No