Morbid Obesity Clinical Trial
Official title:
Bariatric Embolization of Arteries for the Treatment of Obesity
The purpose of this study is evaluate the safety and effectiveness of bariatric embolization
as a minimally-invasive image-guided procedure for morbid obesity. In this procedure,
specific blood vessels to the stomach are blocked in order to suppress some of the body's
signals for feeling hungry, leading to weight loss.
Morbid obesity is currently treated with diet and exercise, medications, and surgery. This
study is designed to help treat obesity using a minimally invasive, non-surgical,
angiographic (through the blood vessel) approach. This procedure is similar to a common
procedure used to treat bleeding within the stomach. This version of the procedure has been
named "bariatric embolization".
Although there are over 40 hormones that limit food intake, there is only one hormone,
ghrelin that has been shown to stimulate (prompt) food intake. In obese patients, eating
fails to suppress ghrelin levels, which is believed to prevent feeling full after a meal and
to lead to overeating. Due to the strong hunger craving effects of ghrelin, this hormone has
been a target for the treatment of obesity and weight loss. More recently, ghrelin has been
shown to have a significant role in the long-term effect of weight loss in bariatric
(obesity) surgery where ghrelin levels are shown to be much lower when compared to untreated
patients.
Recent data collected in animals in has shown that blocking blood vessels to a particular
portion of the stomach (bariatric embolization) can temporarily decrease levels of the
appetite inducing hormone ghrelin, and decrease short-term weight gain. In a study of 5
people, there was a decrease in ghrelin levels and weight loss in the first month after the
procedure, but there is no information about the effects of the procedure over longer periods
of time.
The investigator hopes to learn if bariatric embolization results in safe and effective
weight loss in people who are morbidly obese.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03657927 -
A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients
|
N/A | |
| Recruiting |
NCT04934826 -
Comparison of the Absorption of Hydrolyzed or Intact Proteins in Morbid Obese Patients After the Roux Y Gastric Bypass
|
N/A | |
| Completed |
NCT03181347 -
The Microbiology of Bariatric Surgery
|
N/A | |
| Completed |
NCT03886870 -
Obesity, Lifestyle and Work Intervention
|
N/A | |
| Active, not recruiting |
NCT04433338 -
The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery
|
N/A | |
| Completed |
NCT03553849 -
Utilization of Very Low Calorie Diet in Obese General Surgery Patients
|
N/A | |
| Completed |
NCT05854875 -
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
|
N/A | |
| Not yet recruiting |
NCT03203161 -
Registry on Obesity Surgery in Adolescents
|
||
| Not yet recruiting |
NCT03601273 -
Bariatric Embolization Trial for the Obese Nonsurgical
|
Phase 1 | |
| Recruiting |
NCT02129296 -
Intragastric Balloon, Air Versus Fluid Filled: Randomized Prospective Study
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT01564732 -
Multicenter Prospective Randomized Controlled Trial of Plicated Laparoscopic Adjustable Gastric Banding
|
N/A | |
| Completed |
NCT02033265 -
Ultrasound-Guided Axillary Brachial Plexus Block: Influence of Obesity
|
||
| Not yet recruiting |
NCT01652105 -
Randomized Trial of Preoperative Diets Before Bariatric Surgery
|
N/A | |
| Completed |
NCT01963637 -
Gastric Volumetry by Gastric Tomodensitometry With Gas
|
N/A | |
| Completed |
NCT01955993 -
Fentanyl Metabolism in Obese Adolescents
|
N/A | |
| Completed |
NCT01149512 -
Outcomes of the Adjustable Gastric Band in a Publicly Funded Obesity Program
|
N/A | |
| Terminated |
NCT01759550 -
Prospective Case-Series of Ligasure Advance Pistol Grip and LigaSure Blunt Tip
|
||
| Recruiting |
NCT01685177 -
Single Anastomosis Duodeno-Ileal Bypass vs Standard Duodenal Switch as a Second Step After Sleeve Gastrectomy in the Super-Morbid Obese Patient
|
N/A | |
| Completed |
NCT02929212 -
Effect of Number of Meals on Metabolism After Weight Loss Surgery
|
N/A | |
| Completed |
NCT02414893 -
Hunger/Satiety's Physiopathologic Study in Morbidly Obese Patients
|
N/A |