Neural Injury in Adolescents With Concussion

Mild Traumatic Brain Injury Clinical Trial

Official title: Neural Injury in Adolescents With Concussion

Status Completed

Clinical Trial Summary

This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain injury and to improve understanding of the biological basis of brain pathology in adolescents with concussion. Adolescents with a concussion will undergo neuroimaging and neuropsychology assessments acutely and four months after injury.

Clinical Trial Description

Concussion is a highly prevalent condition in adolescence, but it remains a clinical diagnosis that largely relies on subjective patient report with no reliable objective biomarkers for diagnosis. Traditional clinical brain imaging has not been found useful for concussion as the pathology is generally not visible on conventional acute MRI or CT. The proposed study addresses this gap in concussion diagnosis and management by examining the sensitivity of magnetoencephalography (MEG) for identifying areas of brain injury through detection of abnormal neural activity (slowing) in adolescents with concussion compared to healthy controls. Adolescents with a concussion will complete neuroimaging (MEG and MRI) and neuropsychology assessments at two time points within ten days and then again 4 months post-injury. Healthy controls will complete neuroimaging and neuropsychology assessments at a single time point. ;

Related Conditions & MeSH terms

• Acute Brain Injury
• Brain Concussion
• Brain Injuries
• Brain Injuries, Traumatic
• Concussion, Mild
• Mild Traumatic Brain Injury
• Wounds and Injuries

• NCT number: NCT03011983
• Study type: Observational
• Source: Children's Hospital of Philadelphia
• Status: Completed
• Start date: April 11, 2017
• Completion date: June 1, 2018