Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity

Microbial Colonization Clinical Trial

— PerOME  

Official title:

Effect of Dietary Composition on the Gut Microbiota / Endocannabinoidome Axis in Response to Maximal Aerobic Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04766528
• Other study ID #: 2019-005
• Status: Completed
• Phase: N/A
• Start date: September 6, 2019
• Est. completion date: November 14, 2019

Study information

• Verified date: October 2019
• Source: Laval University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

Description:

Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: November 14, 2019
• Est. primary completion date: November 14, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• women

• 20-30 years old

• healthy

• jogging >1h/week and >3h/week of physical activity

• bmi 18.5-25

Exclusion Criteria:

• postmenopausal, pregnancy or lactation

• pathology or medication

• smoking

• more than 7 alcohol consumption/week

• food allergy, food intolerance or food aversion

• important weight change in the last 6 months

• antibiotics in the last 3 months

• night worker

• pathologies

Related Conditions & MeSH terms

• Activity, Motor
• Communicable Diseases
• Diet Habit
• Infection
• Microbial Colonization

Intervention

Other:
• 3 maximal aerobic tests
Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Locations

Country	Name	City	State
Canada	Institut sur la nutrition et les aliments fonctionnels	Québec

Sponsors (1)

Lead Sponsor	Collaborator
Laval University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endocannabinoid level post physical activity		6 months