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Ex Vivo Study of the Mechanism of Action of Active Ingredients on the Intestinal Microbiota

Microbial Colonization Clinical Trial

Official title:
Stool Collection From Healthy Donors for the ex Vivo Study of the Mechanism of Action of Active Ingredients on the Intestinal Microbiota: Bacteria / Host Interaction Model

Clinical Trial Summary

To design and understand the mechanism of action of different combinations of nutraceuticals coupling bacteria, fibers and polyphenols, which can act on the 4 pillars simultaneously via an innovative ex-vivo model approach coupled with functional and quantitative metagenomics.

Clinical Trial Description

The objective of the study is to collect fresh stools from 4 healthy volunteers, in order to study the mechanism of action of probiotic strains, polyphenols and fibers, alone or in combinations. These fresh stools will be cultured in vitro in fermenters, and the samples taken at different culture times will be analyzed in terms of microbial composition (shotgun metagenomic analysis) and their cellular activity (functional metagenomic analysis). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04895774
Study type Observational
Source Nutri & Co
Contact Hervé Blottière
Phone 06.19.32.28.72
Email herve.blottiere@inrae.fr
Status Not yet recruiting
Phase
Start date September 2021
Completion date October 2021
View Details
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