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NCT04766528 Clinical Trial

Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity

Microbial Colonization Clinical Trial

— PerOME  

Official title:
Effect of Dietary Composition on the Gut Microbiota / Endocannabinoidome Axis in Response to Maximal Aerobic Exercise

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04766528
Other study ID # 2019-005
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 6, 2019
Est. completion date November 14, 2019

Study information
Verified date October 2019
Source Laval University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

Description:

Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Recruitment information / eligibility
Status Completed
Enrollment 11
Est. completion date November 14, 2019
Est. primary completion date November 14, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 20 Years to 30 Years
Eligibility Inclusion Criteria: - women - 20-30 years old - healthy - jogging >1h/week and >3h/week of physical activity - bmi 18.5-25 Exclusion Criteria: - postmenopausal, pregnancy or lactation - pathology or medication - smoking - more than 7 alcohol consumption/week - food allergy, food intolerance or food aversion - important weight change in the last 6 months - antibiotics in the last 3 months - night worker - pathologies

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• 3 maximal aerobic tests
Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet

Locations
Country Name City State
Canada Institut sur la nutrition et les aliments fonctionnels Québec

Sponsors (1)
Lead Sponsor Collaborator
Laval University

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Endocannabinoid level post physical activity 6 months
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