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NCT00431587 Clinical Trial

Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.

Metabolic Syndrome Clinical Trial

Official title:
Changes in Different Fat Compartments During Weight Loss and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00431587
Other study ID # metabo-HMO-CTIL
Secondary ID
Status Recruiting
Phase N/A
First received February 5, 2007
Last updated April 16, 2008
Start date June 2007

Study information
Verified date January 2007
Source Hadassah Medical Organization
Contact Andrei Keidar, MD
Phone 00 972 2 6777384
Email andreik@hadassah.org.il
Is FDA regulated No
Health authority Israel: Israeli Health Ministry Pharmaceutical Administration
Study type Observational

Clinical Trial Summary

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic improvements.

The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments, and their effect on the improvement of the metabolic profile.

In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery

Description:

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern.

The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments.

Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity. It has been previously shown, and it was also partially confirmed in this study, that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels.

This again suggests a threshold of proportional visceral fat loss, above which there is an improvement in insulin sensitivity and other component of metabolic syndrom.

We will quantify the different fat compartments changes after bariatric surgery by means of CT scan.

Recruitment information / eligibility
Status Recruiting
Enrollment 1000
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Morbid obesity,

- Metabolic syndrome

Exclusion Criteria:

- Previous abdominoplasty surgery,

- Previous major abdominal surgey

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Hadassah Medical Organization, Jerusalem

Sponsors (1)
Lead Sponsor Collaborator
Hadassah Medical Organization

Country where clinical trial is conducted

Israel, 

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