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Clinical Trial Summary

The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: - Will treatment with G-CSF allow improvement in markers of ovarian reserve?


Clinical Trial Description

The research team hypothesize that treatment of premature ovarian insufficiency patients with G-CSF to mobilize bone marrow hematopoietic stem cells will allow for improved ovarian reserve markers including antral follicle count, anti-Mullerian hormone (AMH) levels and gonadotropin (FSH) levels. The research team anticipate these outcomes: - Primary outcome: Decreased serum FSH and increased AMH levels and u/s measurement of increased antral follicle count (AFC) - Secondary outcome: Improved ovarian response in IVF cycles if BAFs develop, and spontaneous or IVF pregnancy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06117982
Study type Interventional
Source Trio Fertility
Contact Robert F. Casper, Dr
Phone 416-506-0804
Email casper@lunenfeld.ca
Status Recruiting
Phase Phase 2
Start date October 13, 2023
Completion date October 30, 2024

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