Clinical Trials Logo

Clinical Trial Summary

Acupuncture has been widely used in the treatment of Premature Ovarian Insufficiency(POI), but the selection of acupoints is indeterminate and lacks biological basis.In recent years,some studies suggested the "acupoint sensitization",that is,changes such as pain sensitivity and heat sensitivity appear on the acupoints under disease state.The biological characteristics of acupoints can reflect the state of local tissue and might be a potential factor for guiding acupoint selection. This study aims to compare the temperature and pain threshold of acupoints between POI patients and the healthy population.At the meantime,clinical diagnosis of POI is based on clinical symptoms and Follicle Stimulating Hormone (FSH).However,FSH fluctuates so much that prediction accuracy is not high and clinical application is limited.Therefore, given the lack of proper diagnostic accuracy in POI and the concept of "acupoint sensitization",it is necessary to summarize the changes of biological characteristics of related acupoints under physiological and pathological conditions as an auxiliary means to improve the diagnostic rate of POI.


Clinical Trial Description

The study is a case-control study protocol involving 150 POI patients from three clinical centers and 150 healthy persons in China.The duration of the study is one year, and all patients and healthy people will receive at least 3 infrared thermal imaging examinations of acupoints and pain threshold examinations.The primary outcome is to investigate the difference in the skin temperature and pain threshold of acupoints between POI and healthy persons.In the meanwhile,we will collect FSH, serum estradiol (E2) and some relevant scales,including modified Kupperman Index,Zung's Self-Rating Anxiety Scale(SAS),Zung's Self-Rating Depression Scale(SDS),Traditional Chinese medicine(TCM) constitution scale as second outcomes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06145061
Study type Observational
Source The Third Affiliated hospital of Zhejiang Chinese Medical University
Contact Xiaomei Shao, Ph.D
Phone +8618957130287
Email shaoxiaomei@zcmu.edu.cn
Status Recruiting
Phase
Start date March 1, 2023
Completion date March 30, 2026

See also
  Status Clinical Trial Phase
Recruiting NCT06072794 - A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI) Phase 1
Recruiting NCT06096766 - the Correlation Between Ovarian Function and Serum Biomarkers
Completed NCT04641624 - sFlt- 1, PIGF, and Niacin Levels in Women With Premature Ovarian Insufficiency
Recruiting NCT05308342 - Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency N/A
Not yet recruiting NCT06067529 - A Multicenter Observational Study on the Development and Health Effects of Premature Ovarian Insufficiency
Recruiting NCT05665010 - Precise Stratification of Genetic Risk of Ovarian Function Impairment
Not yet recruiting NCT05385848 - Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study N/A
Completed NCT04475744 - 4-step ASCOT in POI Women to Promote Follicular Rescue Phase 3
Recruiting NCT05279560 - Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation N/A
Recruiting NCT06302543 - Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells N/A
Recruiting NCT05858307 - Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
Completed NCT06228547 - Women's Experience of Premature Ovarian Insufficiency (POI) Diagnosis: Update on Actual Practices and Patient's Follow up
Recruiting NCT06102655 - Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics Early Phase 1
Recruiting NCT05485610 - Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency) N/A
Recruiting NCT05586737 - Immunomodulatory Therapy in Women With Autoimmune Premature Ovarian Insufficiency Phase 2
Recruiting NCT04167033 - Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP) N/A
Not yet recruiting NCT06339489 - The Bone Metabolism Characteristics of Premature Ovarian Insufficiency