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Left vs. Right Non-Inferiority Trial — LeRNIT  

Depression Clinical Trial

Official title:
Left Intermittent Theta Burst Stimulation vs. Right Low Frequency Repetitive Transcranial Magnetic Stimulation Effectiveness in Depression and Suicidal Ideation: A Randomized Non-Inferiority Trial

Clinical Trial Summary

The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).

Clinical Trial Description

In this multi-centre, triple-blinded, non-inferiority trial 420 patients with TRD will be recruited at two academic centres (UBC, CAMH). Patients will be randomised to receive either iTBS or LFR for 30 sessions. The primary outcome will be the improvement on a depression scale. Secondary outcome will be improvement of suicidal ideation. A secondary aim is to test the predictive capacity of a novel, easy to implement heart rate based biomarkers (i.e. heart rate variability). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04999553
Study type Interventional
Source University of British Columbia
Contact Afifa Humaira, BSc
Phone 604-827-1361
Email afifa.humaira@ubc.ca
Status Recruiting
Phase N/A
Start date November 8, 2021
Completion date February 1, 2026
View Details
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