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Major Depressive Episode clinical trials

View clinical trials related to Major Depressive Episode.

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NCT ID: NCT03692910 Active, not recruiting - Clinical trials for Major Depressive Episode

A Study to Evaluate SAGE-217 in Subjects With Bipolar I/II Disorder With a Current Major Depressive Episode - Part A

Start date: August 19, 2018
Phase: Phase 2
Study type: Interventional

This is an open-label study evaluating the safety, tolerability, pharmacokinetics, and efficacy of SAGE-217 in the treatment of subjects with bipolar I/II disorder with a current major depressive episode.

NCT ID: NCT03646058 Not yet recruiting - Suicidal Ideation Clinical Trials

Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

Start date: September 2019
Phase: Phase 3
Study type: Interventional

This study aims at investigating if adjunctive buprenorphine at low dose to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode, and at determining the most effective dose.

NCT ID: NCT03529513 Completed - Clinical trials for Major Depressive Episode

Medibio DDA Confirmatory Performance Study

Start date: August 18, 2017
Study type: Observational

This study will determine whether the Medibio Depression Diagnostic Aid exceeds minimally acceptable thresholds for sensitivity and sensitivity in cases with a current depression episode and non-depressed controls.

NCT ID: NCT03487926 Not yet recruiting - Clinical trials for Inflammatory Bowel Diseases

Microglial Activation in Inflammatory Bowel Disease

Start date: May 1, 2018
Study type: Observational

The purpose of this study is to monitor microglial activation in participants with inflammatory bowel disease (IBD) and investigate the relationship that exists between these patients and their risk of acquiring major depressive episodes (MDE). Patients with both IBD and MDE will be subsequently approached to participate in the study.

NCT ID: NCT03336918 Recruiting - Depression Clinical Trials

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Start date: December 7, 2017
Phase: N/A
Study type: Observational

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.

NCT ID: NCT03323073 Terminated - Clinical trials for Major Depressive Episode

Study of Functional Networks in Resting fMRI

Start date: December 14, 2011
Phase: N/A
Study type: Interventional

The primary purpose is to compare with resting fMRI the functional networks of rest (RTS) in unipolar depression and in bipolar depression. Hypothesis : the main objective of this work is to compare with the rest fMRI the Rest Functional Networks (RFN) in the unipolar depression and in the bipolar depression in order to identify specific biomarkers for each affection. The general hypothesis of this work is that intra- and inter RFN connectivity is different between bipolar patients and unipolar patients. Specifically the investigators assume that connectivity within the default mode network (including ventral mediofrontal cortex, subgenual cingulate cortex, inferior parietal cortex, posterior cingulate cortex) will be increased in unipolar patients compared to bipolar patients.

NCT ID: NCT03256162 Recruiting - Bipolar Depression Clinical Trials

Ketamine as an Adjunctive Therapy for Major Depression

Start date: September 7, 2017
Phase: Phase 1
Study type: Interventional

Randomised, controlled, parallel-group, pilot clinical trial of ketamine vs. midazolam as an adjunctive therapy for depression. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

NCT ID: NCT03254342 Recruiting - Clinical trials for Major Depressive Disorder

MRS and Medication Response: A Pilot Study

Start date: August 6, 2013
Phase: N/A
Study type: Observational

We hope to demonstrate that magnetic resonance spectroscopy can detect brain concentration levels of paroxetine (Paxil) or citalopram (Celexa) or escitalopram (Lexapro) in depressed patients.

NCT ID: NCT03190772 Recruiting - Clinical trials for Major Depressive Episode

The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The study aimes at identifying whether positive expectations have an impact on the way depressive participants experience emotions in the form of sadness.

NCT ID: NCT03113968 Recruiting - Depression Clinical Trials

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

Start date: April 7, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as primary and secondary outcome measures.