Imaging Depression in Parkinson's Disease

Status Not yet recruiting

Clinical Trial Summary

The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of depression.

Clinical Trial Description

This study will compare people with Parkinson's Disease and depression to individuals with Parkinson's Disease without Major Depressive Disorder, Major Depressive Disorder with no Parkinson's, and Healthy Controls. Up to 30 participants will be recruited and enrolled for each of these 4 groups. Participants will be asked to complete one PET and one MRI scan along with study assessments. Once screening and consent is completed, participants will be scheduled for PET and MRI scans. The total duration for participants in this study is 7 hours, including the screening visit and then one additional visit for the scans. The main questions it aims to answer are: 1) Will the Parkinson's depression group exhibit a distinct pattern of synaptic deficits compared to other groups? 2) Will there be differences in functional connectivity across groups? 3) Are there associations between synaptic density and functional connectivity across groups? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06402955
Study type	Observational
Source	Yale University
Contact	Sophie Holmes
Phone	2036854066
Email	sophie.holmes@yale.edu
Status	Not yet recruiting
Phase
Start date	May 2024
Completion date	December 2029

View Details

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