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Clinical Trial Summary

Antidepressant-like effects of tadalafil to its ability to modulate transduction pathways responsible for neuroplasticity. Treatment with tadalafil was shown to be PKG-dependent and lead to increased expression of cGMP, pCREB, BDNF and VGF in the hippocampus and prefrontal cortex (PFC), brain areas relevant to mood disorders pathophysiology. Low-dose tadalafil improved both depressive symptoms in patients with erectile dysfunction.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05030623
Study type Interventional
Source Sadat City University
Contact
Status Recruiting
Phase Phase 1/Phase 2
Start date August 1, 2021
Completion date December 31, 2022

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