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Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder

Major Depressive Disorder Clinical Trial

Official title:
Adjunctive Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder: a Randomized, Double-Blind, Placebo-Controlled Study

Clinical Trial Summary

This study will examine whether semaglutide may improve cognitive function in individuals with major depressive disorder (MDD).

Clinical Trial Description

This is a 16-week, placebo-controlled, randomized, double-blind, clinical trial, involving 60 overweight individuals with MDD and pre-treatment cognitive dysfunction. Study participants will receive one of the following study interventions in addition to 'standard of care' treatment: once-daily semaglutide, initiated at 3 mg/day for 4 weeks, increased to 7 mg/day for 4 more weeks and titrated to 14 mg/day for the subsequent 8 weeks; or matching placebo. Participants will be assessed to examine the effect of semaglutide on their cognitive function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04466345
Study type Interventional
Source University Health Network, Toronto
Contact Rodrigo B. Mansur, MD, PhD
Phone 416 603 5106
Email rodrigo.mansur@uhn.ca
Status Recruiting
Phase Phase 2
Start date October 6, 2021
Completion date October 5, 2024
View Details
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