The UTHealth Ketamine Project

Status Terminated

Clinical Trial Summary

The primary objective of this study is to determine the effectiveness of serial infusions of intravenous (IV) ketamine in adults with treatment resistant depression (TRD).

Clinical Trial Description

Thus, in the current study we want to naturalistically explore the antidepressant effects of serial slow IV infusions (40 minutes) of ketamine at a dose of 0.5 mg/kg, over a treatment period of 8 weeks in an academic psychiatric hospital. This is a minimal sedation treatment. The primary outcome measure of this study will be remission estimated based on the severity of depressive scores. After the 8 weeks of treatment, there will be a four week observational period. During the observational period, participants will receive treatment as usual and will be contacted over the phone for follow-up questions regarding their overall health status, mood and clinical state. They will also complete a neurocognitive task at the end of the 4 week observational period ;

Study Design

Related Conditions & MeSH terms

Bipolar Disorder
Depression
Depressive Disorder
Depressive Disorder, Major
Depressive Disorder, Treatment-Resistant
Disease
Major Depressive Disorder
Treatment Resistant Depression

Clinical Trial Details

NCT number	NCT02882711
Study type	Interventional
Source	The University of Texas Health Science Center, Houston
Contact
Status	Terminated
Phase	Phase 2
Start date	November 7, 2016
Completion date	August 16, 2017

View Details

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