Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation

Major Depressive Disorder Clinical Trial

Official title:

Examining the Effects of Music and Rhythmic Sensory Stimulation on Major Depressive Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02685982
• Other study ID #: 15-9799
• Status: Completed
• Phase: N/A
• First received: February 11, 2016
• Last updated: December 11, 2017
• Start date: April 2016
• Est. completion date: August 2017

Study information

• Verified date: October 2016
• Source: University Health Network, Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e. anhedonia), reduced social functioning, and impaired quality of life. MDD is estimated to affect approximately 2% of Canadian women and 1% of Canadian men at any point in time. The World Health Organization affirms that depression is the leading cause of disability worldwide, with increasing global economic impact.

Standard treatments for depression include basic psychosocial support combined with antidepressant medication or psychotherapy. It has been observed, however, that only 50% of individuals respond to psychological treatment, and only 30-40% of patients achieve full remission after initial treatment with antidepressants. Music- and sound-related therapies have the potential to serve as adjuncts to, or facilitators of, medication.

In this study we will examine the effectiveness of a new therapeutic tool, known as Rhythmic Sensory Stimulation, as an adjunctive treatment for Major Depressive Disorder. Rhythmic Sensory Stimulation is a non-invasive brain stimulation technique that uses periodic pulses of light, sound, or tactile stimulus, to induce changes in the patterns of brain activity. Participants in this study will undertake 30 minutes of daily music intervention self-administered at home, for 5 days per week, for a total of 5 weeks. We will assess depression symptoms, sleep quality, quality of life, and brain activity pre- and post-treatment.

The results of the present study will help to better understand the effectiveness of Rhythmic Sensory Stimulation to the treatment of mood disorders, and contribute to the development of future studies to investigate the neural driving effects of therapies based on Rhythmic Sensory Stimulation.

Description:

Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e. anhedonia), reduced social functioning, and impaired quality of life. MDD is estimated to affect approximately 2% of Canadian women and 1% of Canadian men at any point in time. The World Health Organization affirms that depression is the leading cause of disability worldwide, with increasing global economic impact.

Standard treatments for depression include basic psychosocial support combined with antidepressant medication or psychotherapy. It has been observed, however, that only 50% of individuals respond to psychological treatment, and only 30-40% of patients achieve full remission after initial treatment with antidepressants. Music- and sound-related therapies have the potential to serve as adjuncts to, or facilitators of, medication. Several recent systematic reviews have concluded that music is an effective therapeutic tool with significant results on improving global state, symptoms, and overall functioning, and is also well-accepted by patients.

The goal of this project is to evaluate the effectiveness of music and rhythmic sensory stimulation with low-frequency sounds as an adjunctive therapy for depression. Through a systematic collection of clinical, behavioural and electrophysiological measures, the project also aims to determine the possible mechanisms that underlie the effects of music- and sound-based therapies on symptoms of MDD. In addition to measures of depression severity and symptoms, we are also interested in secondary behavioral measures addressing possible confounding variables, such as anhedonia, quality of life, and individual differences in how people experience reward and pleasure associated with music. These assessments will allow an initial investigation of the neural correlates of the therapeutic effects of music in the treatment of depression, which is greatly warranted to better understand the efficacy of music- and sound-based treatments.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: August 2017
• Est. primary completion date: August 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Outpatients 18 to 60 years of age.

• Meet DSM-IV-TR criteria for major depressive episode (MDE) in major depressive disorder (MDD) without psychotic features, as determined by clinician assessment.

• Episode duration > 3 months.

• MADRS score = 15 (mild to severe symptoms intensity).

• Fluency in English, sufficient to complete the interviews and self-report questionnaires.

• Satisfactory hearing bilaterally based on self-report.

Exclusion Criteria:

• Any Axis I diagnosis (other than MDD), and MDD with psychotic features,that is considered the primary diagnosis.

• Fibromyalgia diagnosis (FIQR score = 39).

• Bipolar-I or Bipolar-II diagnosis (HCL score = 14).

• Presence of a significant Axis II diagnosis (borderline, antisocial), judged as being primary based on clinician assessment.

• High suicidal risk, defined by clinician judgment.

• Substance dependence/abuse in the past 6 months.

• Presence of significant neurological disorders, head trauma, or other unstable medical conditions.

• Acute and active inflammatory conditions, rheumatoid arthritis, osteoarthritis, autoimmune disease.

• History of epilepsy, seizures.

• Hemorrhaging or active bleeding.

• Hearing impairment.

• Thrombosis or heart diseases, including hypotension, arrhythmia, pacemaker, angina pectoris.

• Pregnant or breastfeeding.

• Recovering from recent accident with prolapsed vertebral disc, back or neck injury.

• Started psychological treatment within the past 3 months with the intent of continuing treatment.

• Patients who have changed medication or adjusted medication dosage within 4 weeks.

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Major Depressive Disorder

Intervention

Device:
• Rhythmic Sensory Stimulation
The stimulation consists of 30 minutes of daily stimulation with specially composed relaxing music tracks embedded with gamma frequency sounds of 30-70 Hz range. In this study, the stimuli will be delivered with a portable sound device called Sound Oasis Vibroacoustic Therapy System (VTS-1000) unit, which is a low-voltage consumer product that has two built in mid to high frequency speakers and one built in low frequency (subwoofer-type) speaker. The low frequency sounds played by the subwoofer speaker is experienced as vibrotactile vibration. Although the Intervention of Interest in this study is the Rhythmic Sensory Stimulation with low-frequency sounds, the efficacy of the Sound Oasis VTS-1000 device to deliver the intervention will also be subject to observation.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University Health Network, Toronto	University of Toronto

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in MADRS (Montgomery-Asberg Depression Rating Scale) scores from baseline	Clinical response (= 50% reduction in MADRS scores from baseline)	Assessed at Week 0 (pre-intervention) and Week 6 (post-intervention)

External Links

•   CAN-BIND website