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Inflammation and Electroconvulsive Therapy

Major Depressive Disorder Clinical Trial

Official title:
Does Electroconvulsive Therapy Cause Neuroinflammation? An [18F]FEPPA Positron Emission Tomography Study in Treatment Resistant Depression

Clinical Trial Summary

The purpose of this study is to explore whether electroconvulsive therapy (ECT) accidentally leads to a side effect of brain inflammation. Patients with treatment resistant depression who are planning to take ECT will be subsequently approached to participate in the study.

Clinical Trial Description

The first scan will take place before the first ECT session. The second scan will occur after a minimum of six ECT sessions (average 2.5 weeks). Secondary measures will include mood symptom severity, neurocognitive measures, peripheral inflammatory markers and TSPO genotype.

The hypothesis is that neuroinflammation will be increased by ECT.

There will be no alterations to standard care of depressed patients due to participation in the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02095639
Study type Observational
Source Centre for Addiction and Mental Health
Contact
Status Terminated
Phase N/A
Start date August 2012
Completion date May 2017
View Details
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