Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

Major Depressive Disorder Clinical Trial

Official title:

Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01528748
• Other study ID #: 15599
• Status: Completed
• Start date: April 2011
• Est. completion date: July 2018

Study information

• Verified date: April 2019
• Source: University of Virginia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.

Description:

This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: July 2018
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 65 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years

• Clinical diagnosis of alcohol dependence during the last thirty days

• Interest in changing one's drinking and alleviating depressive symptoms

Exclusion Criteria:

• Please call study site for additional information

Related Conditions & MeSH terms

• Alcohol-Related Disorders
• Alcoholism
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Dysthymic Disorder
• Major Depressive Disorder

Intervention

Behavioral:
• Cognitive Behavioral Analysis System of Psychotherapy
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a behavioral intervention that addresses the unique behavioral characteristics of chronically depressed individuals, most of which are highly relevant for alcoholics as well. CBASP has a structured, individualized, and collaborative (patient and clinician) design. The intervention emphasizes teaching effective coping strategies and employing motivational, cognitive, behavioral, and interpersonal techniques. Individual therapy (1 hour) sessions occur on a weekly basis for a total of 20 sessions over a period of 21 weeks.

Locations

Country	Name	City	State
United States	University of Virginia Center for Addiction Research & Education (UVa CARE)	Charlottesville	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

References & Publications (3)

McCullough JP Jr. Treatment for chronic depression using Cognitive Behavioral Analysis System of Psychotherapy (CBASP). J Clin Psychol. 2003 Aug;59(8):833-46. — View Citation

McCullough, Jr., JP. (2000). Treatment for Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). New York: Guilford Press.

McCullough, Jr., JP. (2001). Skills Training Manual for Diagnosis and Treating Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). New York: Guilford Press.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Depression Rating	Change in depression rating scale over time.	Baseline and 20 weeks
Primary	Drinking behavior	Change in number of drinks consumed per day over time.	Baseline and 20 weeks