Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive Disorder

Major Depressive Disorder Clinical Trial

Official title:

Acceptance and Commitment Therapy vs. Cognitive Therapy for the Treatment of Major Depressive Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01517503
• Other study ID #: METC 10/103
• Status: Completed
• Phase: N/A
• Start date: December 2011
• Est. completion date: August 2015

Study information

• Verified date: July 2019
• Source: VU University of Amsterdam
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.

Description:

The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 82
• Est. completion date: August 2015
• Est. primary completion date: August 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Meeting DSM-IV criteria for MDD

2. Between the ages of 18 and 65-years-old

3. Having sufficient fluency in Dutch to complete treatment and research protocol

Exclusion Criteria:

1. DSM-IV criteria for bipolar disorder (past or present)

2. Psychotic disorders

3. Substance dependence disorders (current or within the past 6 months), or

4. Organic brain syndrome.

5. Borderline or antisocial personality disorder

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Major Depressive Disorder

Intervention

Behavioral:
• Cognitive Therapy
This interventions will target: (a) behavioral dysfunction, (b) situation-specific negative thinking and cognitive distortions, and (c) underlying dysfunctional beliefs or cognitions assumed to be related to the patient's current depression and risk of future depression. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
• Acceptance and Commitment Therapy
This interventions will use (a) acceptance, (b) commitment, (c) mindfulness, and (d) behavior change processes to produce reduction of depressive symptoms. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.

Locations

Country	Name	City	State
Netherlands	PsyQ	Zaandam

Sponsors (1)

Lead Sponsor	Collaborator
VU University of Amsterdam

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR)	Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up	pre-treatment, post-treatment, 6 and 12 months follow-up
Primary	Hamilton Rating Scale for Depression	Change from pre-treatment to post-treatment.	pre-treatment, post-treatment
Secondary	Decentering subscale of the Experiences Questionnaire	Change between sessions and to follow-up.	Pre-treatment, in-treatment, and 6 and 12 months follow-up.
Secondary	Acceptance and Action Questionnaire	Change between sessions and to follow-up.	Pre-treatment, in-treatment, and 6 and 12 months follow-up.
Secondary	Dysfunctional Attitude Scale-revised	Change between sessions to follow-up.	Pre-treatment, in-treatment, and 6 and 12 months follow-up
Secondary	Working Alliance Inventory		3. session
Secondary	Eurohis Quality of Life Scale	Change pre-treatment to post-treatment and to follow-up.	Pre-, post-treatment, 6 and 12 months follow-up
Secondary	Relationship Scales	Change pre-treatment to post-treatment and to follow-up.	Pre-, post-treatment, 12 months follow-up
Secondary	Implicit Attitude Test	Change pre-treatment to post-treatment	Pre- and posttreatment
Secondary	Structured Clinical Interview for DSM-IV (Major Depression Module)	Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment.	Pre-treatment and post-treatment.